Circadian Regulation of Sleep and the Sleep EEG under Constant Sleep Pressure in the Rat

Yasenkov, Roman; Deboer, Tom

doi:10.1093/sleep/33.5.631

Cited by 29 publications

(31 citation statements)

References 58 publications

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“…This measure also showed a clear but reduced diurnal rhythm on each day of CSR, with an amplitude about half of that shown on the baseline day (data not shown). This reduction of daily rhythmicity in NREMS delta power, despite the preservation of the daily rhythmicity of NREMS and other sleep measures throughout CSR days, is consistent with the predominance of homeostatic processes over circadian processes for this sleep intensity measure (57,66).…”

Section: Sleep Patterns During Csrsupporting

confidence: 76%

“…Consistent with these results, Yasenkov and Deboer (66,67) reported that circadian variations in EEG frequencies in the 7-to 25-Hz range during NREMS were maintained during repeated 2 h SOs in constant darkness. These findings suggest that deltarange EEG activity may be under more rigorous homeostatic control, with limited time-of-day influence, while the higherfrequency EEG activity may be modulated by both homeostatic and time-of-day influences.…”

Section: Sleep Patterns During Csrsupporting

confidence: 58%

“…Finally, this study reported reduced amplitude over the day of NREMS amounts and suppression of the rhythm of REMS, in contrast to our findings. These differences may relate to different levels of sleep pressure achieved in these studies or to the impact of the continuing light-dark cycle in our study versus the constant darkness in (66). Future studies will have to determine which aspects of the sleep patterns observed in our study are modulated by endogenous circadian mechanisms (47) and by external lighting cycles (2, 28, 59).…”

Section: Sleep Patterns During Csrmentioning

confidence: 85%

“…A recent study (66) applied repeated cycles of 2 h of SD (by gentle handling) and 2 h of SO over a 2-day CSR cycle to rats housed in constant darkness. It reported increased NREMS amounts and episode durations during SOs during both the subjective day (equivalent to inactive phase) and subjective night (equivalent to active phase), as we also observed using an ultradian CSR cycle.…”

Section: Sleep Patterns During Csrmentioning

confidence: 99%

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Time-of-day modulation of homeostatic and allostatic sleep responses to chronic sleep restriction in rats

Deurveilher

Rusak

Semba

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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To study sleep responses to chronic sleep restriction (CSR) and time-of-day influences on these responses, we developed a rat model of CSR that takes into account the polyphasic sleep patterns in rats. Adult male rats underwent cycles of 3 h of sleep deprivation (SD) and 1 h of sleep opportunity (SO) continuously for 4 days, beginning at the onset of the 12-h light phase (“3/1” protocol). Electroencephalogram (EEG) and electromyogram (EMG) recordings were made before, during, and after CSR. During CSR, total sleep time was reduced by ∼60% from baseline levels. Both rapid eye movement sleep (REMS) and non-rapid eye movement sleep (NREMS) during SO periods increased initially relative to baseline and remained elevated for the rest of the CSR period. In contrast, NREMS EEG delta power (a measure of sleep intensity) increased initially, but then declined gradually, in parallel with increases in high-frequency power in the NREMS EEG. The amplitude of daily rhythms in NREMS and REMS amounts was maintained during SO periods, whereas that of NREMS delta power was reduced. Compensatory responses during the 2-day post-CSR recovery period were either modest or negative and gated by time of day. NREMS, REMS, and EEG delta power lost during CSR were not recovered by the end of the second recovery day. Thus the “3/1” CSR protocol triggered both homeostatic responses (increased sleep amounts and intensity during SOs) and allostatic responses (gradual decline in sleep intensity during SOs and muted or negative post-CSR sleep recovery), and both responses were modulated by time of day.

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Section: Sleep Patterns During Csrsupporting

confidence: 76%

Section: Sleep Patterns During Csrsupporting

confidence: 58%

Section: Sleep Patterns During Csrmentioning

confidence: 85%

Section: Sleep Patterns During Csrmentioning

confidence: 99%

See 2 more Smart Citations

Time-of-day modulation of homeostatic and allostatic sleep responses to chronic sleep restriction in rats

Deurveilher

Rusak

Semba

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Without discriminating the sleep/wake status, especially during the baseline period, the sleep or waking transitions themselves may produce larger fluctuations than test stimulations such as exercise. EEG activities also vary with the circadian rhythm (Grasing and Szeto 1992;Yasenkov and Deboer 2010); thus we only selected and compared the waking baseline values captured during the latest 3 h of the dark period.…”

Section: Discussionmentioning

confidence: 99%

Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity, and heart rate

Kuo

Yen³

et al. 2014

Journal of Neurophysiology

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CC. Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity, and heart rate. J Neurophysiol 111: 2061-2070, 2014. First published March 12, 2014 doi:10.1152/jn.00475.2013.-Involuntarily exercising rats undergo more physical and mental stress than voluntarily exercising rats; however, these findings still lack electrophysiological evidence. Many studies have reported that theta rhythm appears when there is mental stress and that it is affected by emotional status. Thus we hypothesized that the differences between voluntary and involuntary movement should also exist in the hippocampal theta rhythm. Using the wheel and treadmill exercise models as voluntary and involuntary exercise models, respectively, this study wirelessly recorded the hippocampal electroencephalogram, electrocardiogram, and three-dimensional accelerations of young male rats. Treadmill and wheel exercise produced different theta patterns in the rats before and during running. Even though the waking baselines for the two exercise types were recorded in different environments, there did not exist any significant difference after distinguishing the rats' sleep/wake status. When the same movement-related parameters are considered, the treadmill running group showed more changes in their theta frequency (4 -12 Hz), in their theta power between 9.5-12 Hz, and in their heart rate than the wheel running group. A positive correlation between the changes in high-frequency (9.5-12 Hz) theta power and heart rate was identified. Our results reveal various voluntary and involuntary changes in hippocampal theta rhythm as well as divergences in heart rate and high-frequency theta activity that may represent the effects of an additional emotional state or the sensory interaction during involuntary running by rats. wheel running; treadmill running; hippocampal theta rhythm; physical activity; heart rate

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Sleep and Circadian Rhythms

Mistlberger

2015

Circadian Medicine

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Circadian Regulation of Sleep and the Sleep EEG under Constant Sleep Pressure in the Rat

Abstract: In rats, the daily modulation of REM sleep is less pronounced compared to NREM sleep and waking. In contrast to SWA, activity in higher frequencies (7-25 Hz) in the NREM sleep EEG have an endogenous circadian origin and are not influenced by sleep homeostatic mechanisms.

Cited by 29 publications

References 58 publications

Time-of-day modulation of homeostatic and allostatic sleep responses to chronic sleep restriction in rats

Time-of-day modulation of homeostatic and allostatic sleep responses to chronic sleep restriction in rats

Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity, and heart rate

Sleep and Circadian Rhythms

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