Explor Neurosci 2023
DOI: 10.37349/en.2023.00017
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Circadian regulation of the immune-hematopoietic system

Abstract: Earth’s rotation generates the basic circadian rhythm of day and night to which all living organisms must adapt to survive. In mammals, this happens thanks to a central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus and to peripheral clock genes at the cellular level. The main environmental cue capable of synchronizing such clocks is light sensed by retinal ganglion cells signaling through a complex nervous pathway to the pineal gland which ultimately regulates melatonin synthesis that … Show more

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Cited by 2 publications
(1 citation statement)
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“…Regular sleep is crucial for the immune system, and immune-derived factors are needed for regular sleep. Thus, the effect of MLT on inflammatory cytokines might be linked to its sleep-facilitating action, which, in turn, contributes to maintaining a healthy immune system [ 56 ].…”
Section: Melatonin and The Immune Systemmentioning
confidence: 99%
“…Regular sleep is crucial for the immune system, and immune-derived factors are needed for regular sleep. Thus, the effect of MLT on inflammatory cytokines might be linked to its sleep-facilitating action, which, in turn, contributes to maintaining a healthy immune system [ 56 ].…”
Section: Melatonin and The Immune Systemmentioning
confidence: 99%