Circadian rhythm and gestational diabetes: working conditions, sleeping habits and lifestyle influence insulin dependency during pregnancy

Weschenfelder, F; Lohse, K; Schleußner, E; Groten, T

doi:10.1007/s00592-021-01708-8

Cited by 8 publications

(9 citation statements)

References 34 publications

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“…(2013) were reported in the supplementary results tables of the other two transcriptome studies ( 22 – 24 ). Differentially expressed clock genes are consistent with other studies that showed associations between sleep disruptions/night shift work and GDM ( 40 ). Specifically, sleep disruptions in GDM are associated with higher morning blood cortisol and glucose levels, increasing the need for long-acting insulin at night for patients with GDM.…”

Section: Discussionsupporting

confidence: 90%

Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus

et al. 2023

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PurposeGestational diabetes (GDM) is associated with increased risk for preterm birth and related complications for both the pregnant person and newborn. Changes in gene expression have the potential to characterize complex interactions between genetic and behavioral/environmental risk factors for GDM. Our goal was to summarize the state of the science about changes in gene expression and GDM.DesignThe systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.MethodsPubMed articles about humans, in English, from any date were included if they described mRNA transcriptome or microRNA findings from blood samples in adults with GDM compared with adults without GDM.ResultsSixteen articles were found representing 1355 adults (n=674 with GDM, n=681 controls) from 12 countries. Three studies reported transcriptome results and thirteen reported microRNA findings. Identified pathways described various aspects of diabetes pathogenesis, including glucose and insulin signaling, regulation, and transport; natural killer cell mediated cytotoxicity; and fatty acid biosynthesis and metabolism. Studies described 135 unique miRNAs that were associated with GDM, of which eight (miR-16-5p, miR-17-5p, miR-20a-5p, miR-29a-3p, miR-195-5p, miR-222-3p, miR-210-3p, and miR-342-3p) were described in 2 or more studies. Findings suggest that miRNA levels vary based on the time in pregnancy when GDM develops, the time point at which they were measured, sex assigned at birth of the offspring, and both the pre-pregnancy and gestational body mass index of the pregnant person.ConclusionsThe mRNA, miRNA, gene targets, and pathways identified in this review contribute to our understanding of GDM pathogenesis; however, further research is warranted to validate previous findings. In particular, longitudinal repeated-measures designs are needed that control for participant characteristics (e.g., weight), use standardized data collection methods and analysis tools, and are sufficiently powered to detect differences between subgroups. Findings may be used to improve early diagnosis, prevention, medication choice and/or clinical treatment of patients with GDM.

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Section: Discussionsupporting

confidence: 90%

Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus

et al. 2023

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“… Calvo–Ferrandiz et al, 2017 [ 38 ] Spain 100 Narcolepsy Questionnaire Higher incidence of GDM in women with narcolepsy with cataplexy. Weschenfelder et al, 2021 [ 40 ] Germany 234 Circadian rhythm disorders 75-g OGTT (IADPSG) Higher need for long-acting insulin therapy in women with circadian rhythm disturbances and GDM. Wilson et al, 2022 [ 39 ] USA 7742 Narcolepsy Derived from registry No association between narcolepsy and GDM.…”

Section: Introductionmentioning

confidence: 99%

Sleep disorders during pregnancy: an underestimated risk factor for gestational diabetes mellitus

Eleftheriou,

Athanasiadou,

Sifnaios

et al. 2023

Endocrine

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Sleep disorders are highly prevalent during pregnancy and significantly affect women’s health and quality of life. Gestational diabetes mellitus (GDM) is one of the most common metabolic complications during pregnancy and constitutes a significant risk factor for both mother and fetus in the short and the long term. While the association between sleep disorders and type 2 diabetes mellitus (T2DM) is indisputable, it is not clear whether there is a link between sleep disorders and GDM. The aim of this article was to investigate the association between sleep disorders and GDM and whether the treatment of sleep disorders may prevent GDM development. Insomnia, obstructive sleep apnea (OSA), restless legs syndrome (RLS), and narcolepsy were the most common sleep disorders identified during pregnancy and were related to poor sleep quality and short or prolonged sleep duration. They were all associated with an increased risk of GDM. The ideal sleep duration for pregnant women was determined at 8–9 h daily. In conclusion, sleep disorders constitute a risk factor for GDM. It is imperative that prospective studies be conducted to evaluate the effect of the early management of sleep disorders on GDM manifestation and control. Healthcare providers should highlight the importance of sufficient sleep to reinforce pregnancy outcomes.

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“…Light-induced circadian dysregulation has been associated with multiple pregnancy complications including miscarriage 15 – 17 , preterm birth 17 , 18 , and gestational diabetes 19 . There is compelling evidence that pathophysiological functions regulated by the circadian system contribute to PE, where pregnant women with PE frequently are diagnosed with an abnormal circadian blood pressure rhythm 20 .…”

Section: Introductionmentioning

confidence: 99%

Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia

Zhou

Winn

Nguyen

et al. 2022

Sci Rep

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Pre-eclampsia (PE) is a hypertensive condition that occurs during pregnancy and complicates up to 4% of pregnancies. PE exhibits several circadian-related characteristics, and the placenta possesses a functioning molecular clock. We examined the associations of 17 core circadian gene transcripts in placenta with PE vs. non-PE (a mixture of pregnant women with term, preterm, small-for-gestational-age, or chorioamnionitis) using two independent gene expression datasets: GSE75010-157 (80 PE vs. 77 non-PE) and GSE75010-173 (77 PE and 96 non-PE). We found a robust difference in circadian gene expression between PE and non-PE across the two datasets, where CRY1 mRNA increases and NR1D2 and PER3 transcripts decrease in PE placenta. Gene set variation analysis revealed an interplay between co-alterations of circadian clock genes and PE with altered hypoxia, cell migration/invasion, autophagy, and membrane trafficking pathways. Using human placental trophoblast HTR-8 cells, we show that CRY1/2 and NR1D1/2 regulate trophoblast migration. A subgroup study including only term samples demonstrated that CLOCK, NR1D2, and PER3 transcripts were simultaneously decreased in PE placenta, a finding supported by CLOCK protein downregulation in an independent cohort of human term PE placenta samples. These findings provide novel insights into the roles of the molecular clock in the pathogenesis of PE.

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Circadian rhythm and gestational diabetes: working conditions, sleeping habits and lifestyle influence insulin dependency during pregnancy

Cited by 8 publications

References 34 publications

Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus

Systematic review of transcriptome and microRNAome associations with gestational diabetes mellitus

Sleep disorders during pregnancy: an underestimated risk factor for gestational diabetes mellitus

Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia

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