Circadian rhythm of nuclear DNA in adult rat liver

Ruby, John R.; Scheving, Lawrence E.; Gray, SR; White, Karen H.

doi:10.1016/0014-4827(73)90428-x

Cited by 19 publications

(3 citation statements)

References 11 publications

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“…Hepatocytes exhibit circadian variation at the biochemical, morphological, and ultrastructural levels (Bourdel and Forestier, 1982;Castillo et al, 1983;Echave Llanos et al, 1970;Gurr et al, 1978;Hardeland et al, 1973;Kinlaw et al, 1987;Lavigne et al, 1983;Phillipens et al, 1977;Potter et al, 1966;Ruby et al, 1973;Scheving et al, 1987;Seifert, 1980;Steinhardt, 1971; Yeh et al, 1981). This is in part because of the fact that the intestinal nutrients and neuropeptides are released into the portal tract as a consequence of nocturnal feeding.…”

mentioning

confidence: 99%

Circadian variation of epidermal growth factor receptor in mouse liver

Scheving

Tsai²,

Cornett

et al. 1989

Anat. Rec.

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The liver undergoes a biochemical and morphological circadian transformation. In this paper, we document circadian variation in the binding parameters of the hepatic epidermal growth factor receptor (EGFR). Liver membranes were prepared from ad libitum fed or fasted male CD2F1 mice killed at different circadian phases at 4 h intervals. Bmax (maximum binding) and Kd (dissociation constant) varied in a rhythmic fashion. The range of change for Bmax along the 24 h time scale was 423%. For Kd, it was 162%. Both peaked late in the dark span, and decreased late in the light span. Fasting and EGF treatment reduced Bmax and the amplitude of circadian variation.

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confidence: 99%

Circadian variation of epidermal growth factor receptor in mouse liver

Scheving

Tsai²,

Cornett

et al. 1989

Anat. Rec.

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“…Noteworthy, in malignant tumors, complement protein expression is found to be elevated. Since tumor cells and stromal cells both generate abnormal complement proteins, the TME’s complement system becomes aberrantly activated, promoting tumor development by curbing inflammation, stromal cell immunity, and tumor cell expansion, epithelial-mesenchymal transition (EMT), migration, and metastatic spread ( 51 , 52 ).…”

Section: Role Of Complement In the Tumor Microenvironmentmentioning

confidence: 99%

Complement System: An Immunotherapy Target in Colorectal Cancer

2022

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Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system. The complement system is composed of several players, namely component molecules, regulators and receptors. In this review, we discuss the complement system activation in cancer specifically CRC and highlight the possible interactions between the complement system and the various TME components. Additionally, the role of the complement system in tumor immunity of CRC is reviewed. Hence, such work could provide a framework for researchers to further understand the role of the complement system in CRC and explore the potential therapies targeting complement activation in solid tumors such as CRC.

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“…Demgegenüber fanden Gurley et al (1969Gurley et al ( und 1970 (Ruby et al, 1973), wurden die Werte der einzelnen Fraktionen auch auf die spezifische Proteinart bezogen.…”

Section: In Vivo Inkorporation Von ^H-lysin In Die Histoneunclassified

Tagesrhythmische Veränderungen in den Konzentrationen und im Einbau von³H‐Lysin bei Histonen und Nichthiston‐Proteinen aus Zellkernen der Rattenleber

Rzepka

1974

Journal of Interdisiplinary Cycle Research

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Circadian rhythm of nuclear DNA in adult rat liver

Cited by 19 publications

References 11 publications

Circadian variation of epidermal growth factor receptor in mouse liver

Circadian variation of epidermal growth factor receptor in mouse liver

Complement System: An Immunotherapy Target in Colorectal Cancer

Tagesrhythmische Veränderungen in den Konzentrationen und im Einbau von³H‐Lysin bei Histonen und Nichthiston‐Proteinen aus Zellkernen der Rattenleber

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Circadian rhythm of nuclear DNA in adult rat liver

Cited by 19 publications

References 11 publications

Circadian variation of epidermal growth factor receptor in mouse liver

Circadian variation of epidermal growth factor receptor in mouse liver

Complement System: An Immunotherapy Target in Colorectal Cancer

Tagesrhythmische Veränderungen in den Konzentrationen und im Einbau von3H‐Lysin bei Histonen und Nichthiston‐Proteinen aus Zellkernen der Rattenleber

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Product

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Tagesrhythmische Veränderungen in den Konzentrationen und im Einbau von³H‐Lysin bei Histonen und Nichthiston‐Proteinen aus Zellkernen der Rattenleber