Circadian rhythm of the intrarenal renin–angiotensin system is caused by glomerular filtration of liver-derived angiotensinogen depending on glomerular capillary pressure in adriamycin nephropathy rats

Matsuyama, Takashi; Ohashi, Naro; Aoki, Taro; Ishigaki, Sayaka; Isobe, Shinsuke; Sato, Taichi; Fujikura, Tomoyuki; Kato, Akihiko; Miyajima, Hiroaki; Yasuda, Hideo

doi:10.1038/s41440-021-00620-6

Cited by 5 publications

(4 citation statements)

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“…Importantly, the renal Ang II content was also increased, independently of renal renin. In accordance with this finding, Matsuyama et al (2021) showed that the renal Ang II levels correlated with the glomerular filtration of AGT in doxorubicin (Adriamycin) nephropathy rats. Studies using tissue-specific Agt KO mice again showed that the increased renal Ang II generation by podocyte injury was completely dependent on liver-derived AGT (Matsusaka et al, 2014).…”

Section: Water Transportsupporting

confidence: 77%

Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting

et al. 2022

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E.J.H.). A.N. has received consulting fees, speaking honoraria, or both from Daiichi-Sankyo, Taisho, AstraZeneca, Tanabe-Mitsubishi, and Kowa. A.N. received research funds from Boehringer-Ingelheim, Daiichi-Sankyo, Taisho, and Bayer. A.H.J.D. received research funds from Alnylam Pharmaceuticals. D.B. is coinventor of patents entitled "Active low molecular weight variants of angiotensin converting enzyme 2," "Active low molecular weight variants of angiotensin converting enzyme 2 (ACE2) for the treatment of diseases and conditions of the eye," and "Shorter soluble forms of angiotensin converting enzyme 2 (ACE2) for treating and preventing coronavirus infection." D.B. is founder of Angiotensin Therapeutics Inc. D.B. has received consulting fees from AstraZeneca, Relypsa, and Tricida, all unrelated to this work.1 H.L. and F.G. contributed equally to this work. dx.

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Section: Water Transportsupporting

confidence: 77%

Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting

et al. 2022

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“…A signaling pathway was identified between myocytes and steroidogenic cells that appeared to be mediated by the angiotensin II precursor AGT (Supplementary Figure S2D). AGT is known to promote adrenal gland growth and development as well as maintain normal adrenal function and blood pressure homeostasis ( Matsuyama et al, 2021 ). Thus, our results suggest that steroidogenic cells may use AGT to regulate adrenal function.…”

Section: Resultsmentioning

confidence: 99%

Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

Jiang,

Wang,

Zheng

et al. 2024

Zoological Research

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The Chinese tree shrew ( Tupaia belangeri chinensis ) has emerged as a promising model for investigating adrenal steroid synthesis, but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in humans. Here, we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing, spatial transcriptome analysis, mass spectrometry, and immunohistochemistry. We compared the transcriptomes of various adrenal cell types across tree shrews, humans, macaques, and mice. Results showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans, including CYP11B2 , CYP11B1 , CYB5A , and CHGA . Biochemical analysis confirmed the production of aldosterone, cortisol, and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal glands. Furthermore, genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome, primary aldosteronism, hypertension, and related disorders in humans based on genome-wide association studies. Overall, this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal gland. Our comprehensive results (publicly available at http://gxmujyzmolab.cn:16245/scAGMap/) should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

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“…In renal damage with an impaired glomerular filtration barrier, liver-derived angiotensinogen filtered through damaged glomeruli regulates intrarenal RAS activity [ 199 ]. Matsuyama et al further showed that the glomerular filtration of liver-derived angiotensinogen depending on glomerular capillary pressure causes circadian rhythm of the intrarenal RAS with in vivo imaging using multiphoton microscopy [ 200 ]. Fukuda and his colleagues have shown that complement 3 (C3) is a primary factor that activates intrarenal RAS [Supplementary Information 12 - 1 , 2 ].…”

Section: Basic Research: Elucidation Of the “Mosaic” Pathogenesis Of ...mentioning

confidence: 99%