Circadian Rhythms and Psychopathology: From Models of Depression to Rhythms in Clock Gene Expression and Back Again

Verwey, Michael; Al-Safadi, Sherin; Amir, Shimon

doi:10.1016/j.biopsych.2015.05.019

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Factors that may cause a shift in ODC are found to be altered in MDD and other mental health diseases. In particular, increased body temperature was shown in individuals with MDD compared to controls (19), increased brain temperature was reported in individuals with schizophrenia compared to controls (20), and dysregulation of the body temperature rhythm was associated with mouse models of MDD (21). Decreased brain pH was reported to be common in schizophrenia, bipolar disorder, and autism spectrum disorder (22), while higher venous blood pH was found in MDD patients (23).…”

Section: Mdd As a Low-grade Hypoxic State: Disturbances In Oxygen Availability And Transportmentioning

confidence: 99%

Oxygen - Mitochondrial fuel as a missing link in depressive pathophysiology

Mavioğlu¹,

Mack²,

Behnke³

et al. 2021

Preprint

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Major depressive disorder (MDD) causes enormous individual suffering and socioeconomic costs. Biochemical mechanisms leading to MDD are poorly understood and therapy success is not satisfactory. At present, there is evidence of low-grade inflammation, oxidative stress, and most interestingly, a disturbed energy metabolism in MDD and other mental health diseases. Mitochondria play a central part in energy production and stress signaling. Mitochondrial electron transport chain uses molecular oxygen (O2) as final electron acceptor during adenosine triphosphate production attributing a crucial role to an intact O2 supply. Adaptation to altered O2 availability by the highly conserved hypoxic response is essential for maintaining allostasis. Previous research confirmed the role of O2 metabolism in the pathophysiology of MDD. In this perspective article, we compile the evidence linking O2 transport, O2 homeostasis, and mitochondrial energy metabolism to MDD. Furthermore, we hypothesize that inflammation and oxidative stress-related alterations in O2 transport might lead to a hypoxic response, which explains changes in O2 homeostasis and energy metabolism in MDD. Our forthcoming studies will investigate the interplay between energy metabolism and O2 homeostasis in MDD that aim to improve the overall understanding of the pathophysiology of MDD and to guide medical and psychological diagnostics towards a holistic strategy.

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Section: Mdd As a Low-grade Hypoxic State: Disturbances In Oxygen Availability And Transportmentioning

confidence: 99%

Oxygen - Mitochondrial fuel as a missing link in depressive pathophysiology

Mavioğlu¹,

Mack²,

Behnke³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In the last decade, clear health consequences have been observed when circadian rhythms are disrupted by chronic jet-lag in humans, or abnormal circadian periods in rodents (18,19). The links between circadian timing and mental health have also recently implicated in extra-SCN clock gene expression (20). We are excited to see the potential that will be unlocked as these genomic databases continue to expand, with more people and more heterogeneous sampling.…”

mentioning

confidence: 99%