Circadian rhythms in depression

Tsujimoto, Tetsushi; Yamada, Naoto; Saito, Kazutaka; Hanada, Koichi; Takahashi, Saburo

doi:10.1016/0165-0327(90)90037-9

Cited by 79 publications

(5 citation statements)

References 40 publications

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“…While we did not find a relationship between depression 12-15 and rhythm disturbances, we did fmd relationships between mania and rhythm disturbances. 12,13 As has been shown previously, 6,18 we have demonstrated the ability to measure rhythm disturbances utilizing actigraphy in patients with bipolar disorder. Ambulatory monitoring of activity patterns in conjunction with other chronobiological biomarkers may be valuable assessments that could potentially serve as physiological biomarkers of the illness and could lead to potential refinement of endophenotypes in bipolar disorder.…”

Section: Discussionmentioning

confidence: 55%

The Relationship Between Affective State and the Rhythmicity of Activity in Bipolar Disorder

Gonzalez

Tamminga²,

Tohen³

et al. 2014

J. Clin. Psychiatry

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Objective The aim of this study was to test the relationships between mood state and rhythm disturbances as measured via actigraphy in bipolar disorder by assessing the correlations between manic and depressive symptoms as measured via Young Mania Rating Scale (YMRS) and 30-item Inventory for Depressive Symptomatology, Clinician-Rated (IDS-C-30) scores and the actigraphic measurements of rhythm, the 24-hour autocorrelation coefficient and circadian quotient Method The research was condua ed at the University of Texas Southwestern Medical Center at Dallas from February 2, 2009, to March 30, 2010. 42 patients with a DSM-IV-TR diagnosis of bipolar I disorder were induded in the study. YMRS and the IDS-C-30 were used to determine symptom severity. Subjects wore the actigraph continuously for 7 days. The 24-hour autocorrelation coefficient was used as an indicator of overall rhythmicity. The circadian quotient was used to characterize the strength of a circadian rhythm. Results A greater sevefity of manic symptoms correlated with a lower degree of rhythmicity and less robust rhythms of locomotor activity as indicated by lower 24-hour autocorrelation (r = −0.3406, P = .03) and circadian quotient (r = −0.5485, P = .0002) variables, respectively. No relationship was noted between the degree of depression and 24-hour autocorrelation scores (r = −0.1190, P = .45) or circadian quotient (r=0.0083, P= .96). Correlation was noted between the 24-hour autocorrelation and circadian quotient scores (r=0.6347, P<.0001). Conclusions These results support the notion that circadian rhythm disturbances are associated with bipolar disorder and that these disturbances may be associated with clinical signatures of the disorder. Further assessment of rhythm disturbances in bipolar disorder is warranted.

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Section: Discussionmentioning

confidence: 55%

The Relationship Between Affective State and the Rhythmicity of Activity in Bipolar Disorder

Gonzalez

Tamminga²,

Tohen³

et al. 2014

J. Clin. Psychiatry

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“…In contrast, we found a normal distribution of MEQ in our population-based depressed group. Nevertheless, depression may be characterized by increased variability of circadian rhythms such as body temperature (Kripke et al, 1979; Tsujimoto et al, 1990). For example, Taillard et al (1990) found that the circadian rhythm of heart rate might represent a chronobiological marker for some, but not all, depressions.…”

Section: Discussionmentioning

confidence: 99%

“…Taillard et al (1990) found that the circadian rhythm of heart rate might represent a chronobiological marker of some depressions. Others have demonstrated an increased variance in circadian temperature phase in depressives compared to controls (Kripke et al, 1979; Tsujimoto et al, 1990). …”

Section: Introductionmentioning

confidence: 98%

A twin-study of genetic contributions to morningness–eveningness and depression

Toomey

Panizzon

Kremen

et al. 2014

Chronobiology International

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Circadian rhythms are associated with the preference for sleep–wake timing, also known as morningness–eveningness (ME). Both circadian rhythms and ME are influenced by genetic factors. Studies show an association between eveningness and depression. This study investigates the heritability of ME and whether ME and depression share common genetic influences. Study participants (n = 1237) were from the Vietnam Era Twin Study of Aging, a longitudinal study of aging with a baseline in midlife. Participants received the Morningness–Eveningness Questionnaire (MEQ) and the Center for Epidemiologic Studies Depression (CES-D) Scale as part of an extensive neurocognitive and psychosocial assessment. MEQ correlations between members of twin pairs were 0.41 (95% CI 0.31–0.49) for monozygotic (MZ) twins and 0.28 for dizygotic (DZ) twins (95% CI 0.19–0.41). CES-D correlations were 0.38 (95% CI 0.28–0.46) for MZ twins and 0.24 (95% CI 0.14–0.36) for DZ twins. Greater eveningness (i.e. lower MEQ scores) was significantly related to more depression symptoms (phenotypic correlation = −0.15 (95% CI −0.21 to −0.09). In the best fitting model, the heritability estimates are 0.42 for the MEQ and 0.37 for the CES-D. A significant genetic correlation of −0.21 indicated that ME and depression share a significant amount of their underlying genetic variance. The genetic covariance between ME and depression accounted for 59.1% of the phenotypic correlation. Of the CES-D sub-scales, Depressed Mood and Interpersonal Difficulties were significantly heritable, while only Well-Being had a significant genetic correlation with ME. ME and depression are both heritable (ME 0.42, depression 0.37) and share common genetic factors, suggesting an overlap in etiology and the relevance of circadian rhythms to depression. Further study of this relationship may help elucidate etiological factors in depression and targets for treatment.

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“…The finding that respondents with the highest prevalence of trouble staying asleep and early morning awakening were in the most stressful caregiving situations and had high depressive symptoms supports this explanation. Moreover, depression is associated with disturbances in circadian rhythms that have effects on early‐morning awakening 44 . It is possible that the use of antidepressant medications treated underlying depression and thus significantly decreased the risk of early‐morning awakening, although a recent report on the SOF cohort found more sleep disruption in respondents who used selective serotonin reuptake inhibitors 45 …”

Section: Discussionmentioning

confidence: 99%