Circadian Rhythms in Parkinson’s Disease

Abstract

Circadian rhythm is a biological process that regulates neuronal, metabolic, and hormonal functions following a 24-hour cycle. Parkinson’s disease (PD) is a progressive neurodegenerative disorder, and it exhibits diurnal fluctuations in motor and non-motor symptoms. Recently, increasing attention has been paid to circadian dysfunction in PD patients. This review summarizes the existing research on the circadian rhythms in PD especially endogenous markers, clinical symptoms, and available treatment options.

Importance of Circadian Rhythm in Drug Administration Timing

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Chronobiology plays a significant role in comprehending and managing both psychiatric disorders, such as mood and eating disorders [1,2], and physical illnesses, such as hypertension and Parkinson's disease [3][4][5]. By recognizing the disruptions in circadian rhythms associated with these conditions, chronobiological interventions, such as timed medication administration, light therapy, and lifestyle modifications, can be applied to improve treatment outcomes.

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