Circaea lutetiana (L) PLANT AND ITS CHEMICAL COMPOSITION

Kozhantayeva, Akmaral; Tashenov, Yerbolat; Tosmaganbetova, Kuldi; Tazhkenova, Gaukhar; Mashan, Togzhan; Bazarkhankyzy, Aidana; Iskakova, Zh. B.; Sapiyeva, Ardak; Gabbassova, Anar

doi:10.31788/rjc.2022.1536870

Cited by 3 publications

(1 citation statement)

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“…Since herbal medicine is becoming increasingly popular, it is critical to meet the needs of both consumers and manufacturers in terms of high-quality herbal raw materials [1].…”

Section: Introductionmentioning

confidence: 99%

Paeonia anomala (Paeoniaceae) component composition and antioxidant, antiradical and cytotoxic activity

Sarkytbayeva¹,

Kubentayev²,

Kurmanbayeva³

et al. 2023

BMG

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Paeonia anomala L. is a valuable medicinal plant in the world. The aim of this study was the study of composition of the plant P. anomala and its antioxidant, antiradical and cytotoxic activities. The underground part of P. anomala was extracted with ethanol and the composition was determined using gas chromatography with mass spectrometric detection (Agilent 7890A/5975C). Methyl salicylate (32.07 %), sucrose (11.23 %), benzoic acid (9.12 %), cyclopropyl carbine (7.7 %), 2,5-dimethyl-4-hydroxy-3(2H)-furanone (4.77 %), benzoic acid, 2,4-dihydroxy-3,5,6-trimethyl-, methyl ester (4.48 %), are the main components. The ethyl acetate extract of the underground part (root) of P. anomala at concentrations of 0.25 and 0.5 mg/ml has a low content, and at concentrations of 0.75 and 1 mg/ml, an average antioxidant activity compared to the antioxidant activity of ascorbic and gallic acids. The ethanol extract of the underground part of P. anomala at concentrations of 0.25 and 0.5 mg/ml has an average, and at concentrations of 0.75 and 1 mg/ml the highest antioxidant activity compared to the antioxidant activity comparators. Also, the ethanol extract of the underground part P. anomala has the highest antiradical activity in all concentrations compared to the antiradical activity of gallic acid. Ethanol and ethyl acetate extracts of the underground part of P. anomala in all concentrations do not show cytotoxicity.

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“…Since herbal medicine is becoming increasingly popular, it is critical to meet the needs of both consumers and manufacturers in terms of high-quality herbal raw materials [1].…”

Section: Introductionmentioning

confidence: 99%

Paeonia anomala (Paeoniaceae) component composition and antioxidant, antiradical and cytotoxic activity

Sarkytbayeva¹,

Kubentayev²,

Kurmanbayeva³

et al. 2023

BMG

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Evaluation of the Capparis Herbacea Willd's Chemistry, Antioxidant and Cytotoxic Activity

Tleuberlina,

Mamurova,

Iskakova

et al. 2023

AIAAMC

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Background:: Glioma is the most common and devastating brain tumor. In recent years, doxorubicin (DOX) is one of the drugs used in the treatment of gliomas, but it has side effects and poor clinical outcomes. Therefore, the delivery of drugs to the tumor site by targeted transport is a new approach to tumor treatment. Objective:: This study focuses on the anti-tumor effects of GFAP-modified drug-carrying liposomes loaded with DOX (GFAP-DOX-LPs) on gliomas. Method:: GFAP-DOX-LPs were prepared by solvent evaporation method. After characterization analysis of GFAP-DOX-LPs, the encapsulation efficiency, the drug loading capacity and in vitro release performance were determined. Then, the MTT method was used to investigate the cytotoxicity and proliferative behavior of U251 and U87 cell lines. After that, flow cytometry was used to investigate the effect of the drug administration group on tumor cell apoptosis. Eventually, the anti-tumor activity was tested in vivo. Results:: The average particle size of GFAP-DOX-LPs was determined to be 116.3 ± 6.2 nm, and the average potential was displayed as 22.8 ± 7.2 mv. Besides, the morphology of the particle indicated a spherical shape. The encapsulation rate and drug loading were calculated and determined, which were 91.84 ± 0.41% and 9.27 ± 0.55%. In an acidic medium, the DOX release rate reached about 87%. GFAP-DOX-LPs could target glioma cells with low cytotoxicity and inhibit glioma cell proliferation with high efficiency, resulting in promoting apoptosis. The anti-tumor effect of GFAP-DOX-LPs was significantly enhanced. At the same time, the number of GFAPpositive cells in tumor tissues was significantly lower after treatment. Therefore, the overall survival time could be significantly prolonged. Conclusion:: The prepared GFAP-DOX-LPs had good targeting and glioma cell inhibition ability. This demonstrated the promising application of the prepared liposomes in tumor targeting, especially in the field of targeted drug delivery for the treatment of brain tumor.

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Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L.

Kozhantayeva,

Tursynova,

Kolpek

et al. 2024

Pharmaceuticals

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The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from Chamaenerion latifolium L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 ± 3.44 mg GAE/g DE) and flavonoid content (24.18 ± 1.06 mg QE/g DE) compared to ChL-EtOAc. HPLC-UV-ESI/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC50 = 21.31 ± 0.65 μg/mL and 18.13 ± 0.15 μg/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain Candida albicans. These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.

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Circaea lutetiana (L) PLANT AND ITS CHEMICAL COMPOSITION

Cited by 3 publications

References 0 publications

Paeonia anomala (Paeoniaceae) component composition and antioxidant, antiradical and cytotoxic activity

Paeonia anomala (Paeoniaceae) component composition and antioxidant, antiradical and cytotoxic activity

Evaluation of the Capparis Herbacea Willd's Chemistry, Antioxidant and Cytotoxic Activity

Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L.

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