CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Jin, Yue; Che, Xiaofang; Qu, Xiujuan; Li, Xin; Lü, Wenqing; Wu, Jie; Wang, Yizhe; Hou, Kezuo; Li, Ce; Zhang, Xiaojie; Zhou, Jianping; Liu, Yunpeng

doi:10.3389/fonc.2020.01612

Cited by 31 publications

(26 citation statements)

References 50 publications

(59 reference statements)

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“…miRNA-653-5p, a typical multifunctional miRNA located on chromosome 7, has been reported to promote prostate cancer cell proliferation and invasion (Fu et al, 2019) and to restrict neuroblastoma progression (Chi et al, 2019). In GC, miR-653-5p has been shown to target circHIPK3 under chronic hypoxic conditions and attenuate the metastatic ability of hypoxia-resistant GC cell lines (Jin et al, 2020). These results were contradictory to the findings in this study.…”

Section: Discussioncontrasting

confidence: 96%

MicroRNA-653-5p Promotes Gastric Cancer Proliferation and Metastasis by Targeting the SOCS6-STAT3 Pathway

Hong

Chen

et al. 2021

Front. Mol. Biosci.

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MicroRNAs (miRNAs) are emerging as significant regulators of the tumorigenesis of gastric cancer (GC), and may be effective biomarkers for diagnosis, prognosis, and therapeutic targeting for GC. In this study, miR-653-5p was found to be significantly upregulated in GC tissues, serum, and cell lines and was strongly associated with poor prognosis in patients with GC. Furthermore, miR-653-5p promoted GC cell proliferation and metastasis in vivo and in vitro. Suppressor of cytokine signaling 6 (SOCS6) was directly targeted by miR-653-5p, and SOCS6 attenuated miR-653-5p-mediated GC cell growth, migration, and invasion. In addition, SOCS6-mediated inactivation of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway was also reversed by the administration of miR-653-5p. The findings from this study support a novel regulatory axis between miR-653-5p, SOCS6, and JAK2/STAT3 that may be a target for diagnosis and therapeutic intervention for GC.

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Section: Discussioncontrasting

confidence: 96%

MicroRNA-653-5p Promotes Gastric Cancer Proliferation and Metastasis by Targeting the SOCS6-STAT3 Pathway

Hong

Chen

et al. 2021

Front. Mol. Biosci.

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“…It was observed that circ-HIPK3 upregulation by HIF-2α increased GC cell migration and invasion through the miR-338-3p/miR-653-5p/NPR1 axis. There was also circ-HIPK3 upregulation in gastric cancer (GC) tissues in comparison with normal margins [48]. Tyrosine phosphatase functions as a regulator of protein folding in endoplasmic reticulum.…”

Section: Induced Cell Proliferationmentioning

confidence: 99%

Molecular interactions of miR-338 during tumor progression and metastasis

Moghbeli

2021

Cell Mol Biol Lett

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Background Cancer, as one of the main causes of human deaths, is currently a significant global health challenge. Since the majority of cancer-related deaths are associated with late diagnosis, it is necessary to develop minimally invasive early detection markers to manage and reduce mortality rates. MicroRNAs (miRNAs), as highly conserved non-coding RNAs, target the specific mRNAs which are involved in regulation of various fundamental cellular processes such as cell proliferation, death, and signaling pathways. MiRNAs can also be regulated by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). They are highly stable in body fluids and have tumor-specific expression profiles, which suggest their suitability as efficient non-invasive diagnostic and prognostic tumor markers. Aberrant expression of miR-338 has been widely reported in different cancers. It regulates cell proliferation, migration, angiogenesis, and apoptosis in tumor cells. Main body In the present review, we have summarized all miR-338 interactions with other non-coding RNAs (ncRNAs) and associated signaling pathways to clarify the role of miR-338 during tumor progression. Conclusions It was concluded that miR-338 mainly functions as a tumor suppressor in different cancers. There were also significant associations between miR-338 and other ncRNAs in tumor cells. Moreover, miR-338 has a pivotal role during tumor progression using the regulation of WNT, MAPK, and PI3K/AKT signaling pathways. This review highlights miR-338 as a pivotal ncRNA in biology of tumor cells.

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“…In particular, under hypoxia circHIPK3 is induced by HIF-2α and, through the direct interaction and sponging with miR-653-5p and miR-338-3p, abrogated the suppression of neuropilin1 with consequent promotion of metastases. In support of these results, dataset analysis indicated neuropilin1 as a poor prognostic biomarker for patients with gastric cancer [ 79 ] .…”

Section: Introductionmentioning

confidence: 78%

SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia

Valentini

Martile

Bufalo

et al. 2021

J Exp Clin Cancer Res

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Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy. Semaphorins, a family of about 20 secreted, transmembrane and GPI-linked glycoproteins, and their cognate receptors (plexins and neuropilins) play a pivotal role in the crosstalk between cancer and stromal cells present in the tumor microenvironment. Many studies reported that some semaphorins are involved in the development of a permissive tumor niche, guiding cell-cell communication and, consequently, the development and progression, as well as the response to therapy, of different cancer histotypes, including melanoma.In this review we will summarize the state of art of semaphorins regulation by hypoxic condition in cancer with different origin. We will also describe evidence about the ability of semaphorins to affect the expression and activity of transcription factors activated by hypoxia, such as hypoxia-inducible factor-1. Finally, we will focus our attention on findings reporting the role of semaphorins in melanocytes transformation, melanoma progression and response to therapy. Further studies are necessary to understand the mechanisms through which semaphorins induce their effect and to shed light on the possibility to use semaphorins or their cognate receptors as prognostic markers and/or therapeutic targets in melanoma or other malignancies.

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CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Abstract: Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment.

Cited by 31 publications

References 50 publications

MicroRNA-653-5p Promotes Gastric Cancer Proliferation and Metastasis by Targeting the SOCS6-STAT3 Pathway

MicroRNA-653-5p Promotes Gastric Cancer Proliferation and Metastasis by Targeting the SOCS6-STAT3 Pathway

Molecular interactions of miR-338 during tumor progression and metastasis

SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia

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