CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract

Liu, Junliang; Zhang, Jinling; Zhang, Guowei; Zhou, Tianqiu; Zou, Xi; Guan, Huaijin; Wang, Yong

doi:10.18632/aging.202470

Cited by 19 publications

(9 citation statements)

References 51 publications

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“…Besides, Liu and his colleagues indicated that circular RNA circMRE11A_013 (circMRE11A) knockdown contributed to the proliferation of SRA01/04 cells by initiating ataxia-telangiectasia mutated kinase (ATM)/p53/p21 signaling pathway through interaction with UBX domain-containing protein 1 [29]. In the present research, we revealed the function of circ_EPB41 in ARC formation for the first time.…”

Section: Discussionsupporting

confidence: 50%

“…CircRNA zinc finger protein 292 (circZNF292) was capable of attenuating hydrogen peroxide-caused promotion of cell apoptosis and oxidative stress, and the underneath mechanism was manipulated by circZNF292-miR-222-3p-E2F transcription factor 3 (E2F3) regulatory axis [ 28 ]. Besides, Liu and his colleagues indicated that circular RNA circMRE11A_013 (circMRE11A) knockdown contributed to the proliferation of SRA01/04 cells by initiating ataxia-telangiectasia mutated kinase (ATM)/p53/p21 signaling pathway through interaction with UBX domain-containing protein 1 [ 29 ]. In the present research, we revealed the function of circ_EPB41 in ARC formation for the first time.…”

Section: Discussionmentioning

confidence: 99%

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Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner

Zhou

Huang

et al. 2021

Bioengineered

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner

Zhou

Huang

et al. 2021

Bioengineered

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“…Cataracts, a primary cause of blindness worldwide, seriously influence the quality of human life [ 1 , 2 ]. According to the location of the opacification of the eye lens, they are classified into cortical, nuclear, and posterior subcapsular [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Chen

Liu

et al. 2022

Pharmaceuticals

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Nanoparticle-based drug delivery systems, which can overcome the challenges associated with poor aqueous solubility and other harmful side effects of drugs, display potent applications in cataract treatment. Herein, we designed a nanosystem of gold nanoparticles containing resveratrol (RGNPs) as an anti-aging agent to delay cataracts. The spherical RGNPs had a superior ability to inhibit hydrogen peroxide-mediated oxidative stress damage, including reactive oxygen species (ROS) production, malondialdehyde (MDA) generation, and glutathione (GSH) consumption in the lens epithelial cells. Additionally, the present data showed that RGNPs could delay cellular senescence induced by oxidative stress by decreasing the protein levels of p16 and p21, reducing the ratio of BAX/BCL-2 and the senescence-associated secretory phenotype (SASP) in vitro. Moreover, the RGNPs could also clearly relieve sodium selenite-induced lens opacity in a rat cataract model. Our data indicated that cell senescence was reduced and cataracts were delayed upon treatment with RGNPs through activating the Sirt1/Nrf2 signaling pathway. Our findings suggested that RGNPs could serve as an anti-aging ingredient, highlighting their potential to delay cataract development.

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“…Previous studies of the relationship between age-related cataracts and Atm have reported that UVB exposure induces DNA damage in LECs, which increases ATM activation and p53/ p21 induction, leading to cell cycle arrest and senescence [46]. In our prior study, we found that Plk3 and Atm were involved in opacity formation in galactose-induced cataract, and activated apoptotic signaling [13].…”

Section: Plos Onementioning

confidence: 65%

Atm inhibition decreases lens opacity in a rat model of galactose-induced cataract

et al. 2022

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Cataract causes vision loss and blindness due to formation of opacities of the lens. The regulatory mechanisms of cataract formation and progression remain unclear, and no effective drug treatments are clinically available. In the present study, we tested the effect of ataxia telangiectasia mutated (Atm) inhibitors using an ex vivo model in which rat lenses were cultured in galactose-containing medium to induce opacity formation. After lens opacities were induced by galactose, the lenses were further incubated with the Atm inhibitors AZD0156 or KU55933, which decreased lens opacity. Subsequently, we used microarray analysis to investigate the underlying molecular mechanisms of action, and extracted genes that were upregulated by galactose-induced opacity, but not by inhibitor treatment. Quantitative measurement of mRNA levels and subsequent STRING analysis revealed that a functional network consisting primarily of actin family and actin-binding proteins was upregulated by galactose treatment and downregulated by both Atm inhibitors. In particular, Acta2 is a known marker of epithelial-mesenchymal transition (EMT) in epithelial cells, and other genes connected in this functional network (Actn1, Tagln, Thbs1, and Angptl4) also suggested involvement of EMT. Abnormal differentiation of lens epithelial cells via EMT could contribute to formation of opacities; therefore, suppression of these genes by Atm inhibition is a potential therapeutic target for reducing opacities and alleviating cataract-related visual impairment.

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CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract

Cited by 19 publications

References 51 publications

Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner

Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Atm inhibition decreases lens opacity in a rat model of galactose-induced cataract

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