2020
DOI: 10.1186/s12943-020-01160-2
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CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification

Abstract: Background: Aberrant expression of circular RNAs contributes to the initiation and progression of cancers, but the underlying mechanism remains elusive. Methods: RNA-seq and qRT-PCR were performed to screen differential expressed circRNAs between gastric cancer tissues and adjacent normal tissues. Candidate circRNA (circMRPS35) was screened out and validated by qRT-PCR. Cell proliferation and invasion ability were determined by CCK-8 and cell invasion assays. RNA-seq, GO-pathway, RNA pull-down and ChIRP were f… Show more

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Cited by 134 publications
(108 citation statements)
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“…ChIRP assay was implemented in HGC-27/MSC-exo and AGS/MSC-exo cells in line with the previous protocol 27 . All probes were synthesized with BiotinTEG at the 3' end.…”
Section: Chromatin Isolation By Rna Purification (Chirp) Assaymentioning
confidence: 99%
“…ChIRP assay was implemented in HGC-27/MSC-exo and AGS/MSC-exo cells in line with the previous protocol 27 . All probes were synthesized with BiotinTEG at the 3' end.…”
Section: Chromatin Isolation By Rna Purification (Chirp) Assaymentioning
confidence: 99%
“…9,10 CircRNA is considered to be an important regulator of cancer progression and mainly plays anti-cancer or pro-cancer role. 11,12 At present, many circRNAs are found in NSCLC, and their functions are illuminated. For instance, hsa_circ_0011780 has been proved to be an anti-cancer circRNA of NSCLC, which can inhibit the proliferation and metastasis of NSCLC cells.…”
Section: Introductionmentioning
confidence: 99%
“…As circRNA has the characteristics of stability and tissue specificity, thus it may become a tumor marker and be involved in progression of gastric cancer. Present study shows that Circ_0032821 promotes gastric cancer development by activating the MEK1/ ERK1/ 2; CircMRPS35 inhibits the progression of gastric cancer; Silencing RACRACGAP1 can enhance the sensitivity to Apatinib by targeting miR‐3657; CircRNA_0005075 inhibits gastric cancer growth via miR‐431/ p53/ epithelial stromal transformation axis; circ_0006282 promotes gastric cancer growth through miR‐155/ FBXO22 axis 11‐15 …”
Section: Discussionmentioning
confidence: 72%