CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis

Zheng, Fushuang; Xu, Ran

doi:10.1016/j.biopha.2020.109828

Cited by 77 publications

(65 citation statements)

References 37 publications

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“…Moreover, knockdown of LINC00707 suppressed expression of anti–apoptotic protein BCL‐2 and enhanced expression of pro–apoptotic protein Bax, thus promoting cisplatin sensitivity 4 . CircPVT1 contributed to cisplatin and pemetrexed resistance in lung adenocarcinoma by positively regulating MRP1 through sponging miR‐145 3 . Analogously, lncRNA CACS15 contributed to oxaliplatin resistance in CRC cancer through the miR‐145/MRP1 axis 18 .…”

Section: Mir‐145 In Drug Resistancementioning

confidence: 99%

“…Researchers are currently attempting to explore the target genes of miR‐145 and their signaling pathways involved in altering therapeutic response, which is significant for the development of miRNA‐related therapies. Strikingly, various research has disclosed that miR‐145 acts in reversion of therapeutic resistance in multiple tumors, including lung cancer, 3‐6 esophageal squamous cell carcinoma (ESCC), 7‐9 ovarian carcinoma, 10,11 glioma, 12,13 hepatocellular carcinoma (HCC), 14‐16 breast cancer, 17 colorectal cancer (CRC) 18‐21 prostate cancer, 22,23 bladder cancer, 24 gastric cancer (GC), 25,26 pancreatic adenocarcinoma 27 and cervical cancer 28,29 …”

Section: Introductionmentioning

confidence: 99%

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MiR‐145 in cancer therapy resistance and sensitivity: A comprehensive review

Hua

Deng

et al. 2020

Cancer Science

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MircoRNA (miRNA) are a group of small, non–coding, regulatory RNA with an average length of approximately 22 nucleotides, which mostly modulate gene expression post–transcriptionally through complementary binding to the 3ʹ‐untranslated region (3ʹ‐UTR) of multiple target genes. Emerging evidence has shown that miRNA are frequently dysregulated in a variety of human malignancies. Among them, microRNA‐145 (miR‐145) has been increasingly identified as a critical suppressor of carcinogenesis and therapeutic resistance. Resistance to tumor therapy is a challenge in cancer treatment due to the daunting range of resistance mechanisms. We reviewed the status quo of recent advancements in the knowledge of the functional role of miR‐145 in therapeutic resistance and the tumor microenvironment. It may serve as an innovative biomarker for therapeutic response and cancer prognosis.

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Section: Mir‐145 In Drug Resistancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MiR‐145 in cancer therapy resistance and sensitivity: A comprehensive review

Hua

Deng

et al. 2020

Cancer Science

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“…However, whether it affects the expression and function of ABC transporters is worth further investigation [38,39]. Silencing of the circRNA PVT1 (circPVT1) decreases the expression of ABC subfamily B member 1 (ABCB1 or Pgp) and ABCC1 [40,41]. CircSETD3 could bind to miR-520 to increase the level of ABCG2, leading to a decreased intracellular accumulation of gefitinib [36].…”

Section: Increased Drug Efflux Transporters or Decreased Influx Channelsmentioning

confidence: 99%

“…The expression levels of ciRS-7 and circPVT1 are increased in pemetrexed-and cisplatin-resistant lung cancer cells. They reduce the efficiency of neoadjuvant chemotherapy (pemetrexed and cisplatin) by inhibiting the EGFR/PI3K pathway and the miR-145-5p/multidrug resistance protein 1 (MRP1 or ABCC1) axis, respectively [41,121].…”

Section: Respiratory System Cancermentioning

confidence: 99%

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

et al. 2020

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Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs, DNAs and proteins, to regulate cell activities in physiology and pathology. Accumulating evidence indicates that circRNAs play critical roles in tumor genesis, development, and sensitivity to radiation and chemotherapy. Radiotherapy and chemotherapy are two primary types of intervention for most cancers, but their therapeutic efficacies are usually retarded by intrinsic and acquired resistance. Thus, it is urgent to develop new strategies to improve therapeutic responses. To achieve this, clarification of the underlying mechanisms affecting therapeutic responses in cancer is needed. This review summarizes recent progress and mechanisms of circRNAs in cancer resistance to radiation and chemotherapy, and it discusses the limitations of available knowledge and potential future directions.

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“…For example, as described above, circPVT1 is upregulated in gastric cancer, NSCLC and osteosarcoma. This upregulation leads to multidrug resistance, including Taxol, oxaliplatin and cisplatin [92,135,143]. Precise circPVT1-specific RNA drugs may have potential applications in treating multidrug resistance in all these tumors.…”

Section: Future Potentialmentioning

confidence: 99%

CircRNAs in anticancer drug resistance: recent advances and future potential

Wang

Jiang

et al. 2020

Mol Cancer

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CircRNAs are a novel class of RNA molecules with a unique closed continuous loop structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue specificity, and can play a biological regulatory role at various levels, such as transcriptional and posttranscriptional levels. Numerous studies have indicated that circRNAs serve a crucial purpose in cancer biology. CircRNAs regulate tumor behavioral phenotypes such as proliferation and migration through various molecular mechanisms, such as miRNA sponging, transcriptional regulation, and protein interaction. Recently, several reports have demonstrated that they are also deeply involved in resistance to anticancer drugs, from traditional chemotherapeutic drugs to targeted and immunotherapeutic drugs. This review is the first to summarize the latest research on circRNAs in anticancer drug resistance based on drug classification and to discuss their potential clinical applications.

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CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis

Cited by 77 publications

References 37 publications

MiR‐145 in cancer therapy resistance and sensitivity: A comprehensive review

MiR‐145 in cancer therapy resistance and sensitivity: A comprehensive review

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

CircRNAs in anticancer drug resistance: recent advances and future potential

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