Circular dichroism study of the irreversibility of conformational changes induced by polyamine-linked dinuclear platinum compounds

The status of platinum anticancer drugs in the clinic and in clinical trials

“…175, 176 More recently it has been shown to be able to form phosphate clamps with the backbone of DNA 177 and have possible interactions with membrane phospholipids.…”

Improving platinum(II)-based anticancer drug delivery using cucurbit[n]urils

“…In this case, CB [7] had no significant affect on the cytotoxicity of the metal complex. Similarly, for BBR3571, a dinuclear platinum complex with potent in vitro cytotoxicity in a number of cisplatin sensitive and resistant cancer cell lines [60][61][62][63][64][65], the metal complex has identical IC 50 values (0.0115 lM) in the L1210 line with and without CB [7]. In the L1210/DDP resistant line only a slight decrease in cytotoxicity is observed, IC 50 values of 0.0075 and 0.009 lM for the free and encapsulated metal complex, respectively [66].…”

Synthesis, characterization, and DNA-binding studies of ruthenium complexes [Ru(tpy)(ptn)]2+ and Ru(dmtpy)(ptn)]2+

“…Recent studies have revealed that the B→Z transition can also be mediated by Z-DNA-binding proteins [11]. In addition, the B→Z transition is facilitated by the presence of chiral drugs [12], certain organic solvents [13,14], polyamine [15], coordination complexes of Ni(II) [16], Zn(II) [17], Pt(II) [18], Cu(II) [19], Cr(III) [20], Co(III) [21], Ru(III) [22], and Ru(II) [23][24][25], and rare earth-amino acid complexes [26]. The inherent instable properties of Z-DNA bring great difficulties for study.…”