Synthesis, characterization, and DNA-binding studies of ruthenium complexes [Ru(tpy)(ptn)]2+ and Ru(dmtpy)(ptn)]2+

Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents

“…Viscosity changes were measured using CT DNA with increasing concentrations of the complexes as shown in figure 5. The effects of ofloxacin, 1, 2, and 3 versus [Ru(bpy) 3 ] 2+ and EB (ethidium bromide) on the relative viscosity of rod-like DNA are shown in figure 5. [Ru(bpy) 3 ] 2+ interacts with DNA in a classical electrostatic effect with little changes in the viscosity of CT DNA and EB interacts with DNA in a classical intercalating mode showing increasing viscosity [35,36]. The relative viscosity of the DNA does not change as the amounts of ofloxacin, 1, 2, and 3 increase, which is similar with [Ru(bpy) 3 ] 2+ .…”

Synthesis and characterization of chiral ruthenium(II) complexes Λ/Δ-[Ru(bpy)2(H2iip)](ClO4)2 as stabilizers of c-myc G-quadruplex DNA

“…n (bases/comp) These data indicate that both isomers enhance the thermodynamic stability of c-myc oligomer [39,40]. These data are in agreement with those above, indicating that the Λ-isomer binds with c-myc G-quadruplex DNA more tightly than does the Δ-isomer.…”

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

“…Furthermore, two Ru II complexes with tridentate ligands of poorer planarity were found to induce aB -Z conformational transition of DNA. [39] This is comparable to the fact that D-Ru2 and L-Ru2 with a smallerp lanara rea can transform B-DNA to Z-DNA. Consequently,t he planarity and length of ligands are closely related to the biological effects of D-Ru1, L-Ru1, D-Ru2, L-Ru2, D-Ru3,a nd L-Ru3.I na ddition, the extent of the hypochromism and the intrinsic binding constants K b of the complexes when bound to DNA increase in the order of (Table S3, Figure S24, Supporting Information), suggesting that D-Ru2, L-Ru2, D-Ru3,a nd L-Ru3 with larger planar ligands can bind more strongly to DNA throughi ntercalation comparedt oD-Ru1 and L-Ru1.W e can conclude that the effect of ligand planarity on the interaction of complexes with DNA is the keyf actor for regulating DNA conformation.…”

“…[20] Recently,r uthenium(II) complexes have attracted increasing attention in the design of DNA binding and recognition agents [21][22][23][24][25][26][27][28][29][30][31][32] as well as anticancer drugs targeting DNA. [33][34][35][36][37][38] SomeD NA intercalative Ru II complexes have been previously reported to induce DNA B-Z conformational transfer, [39][40][41][42] as well as some Ru II DNA intercalating complexes,w hichc an con-denseD NA. [42][43][44][45][46][47] In this work,o ur results serve to demonstrate the structurale ffect of DNA intercalators on their interference with DNA high-order structures, and to determine the link betweent he B-Z DNA conformational transformation andD NA condensation.…”