Circular RNA circ_0061140 accelerates hypoxia-induced glycolysis, migration, and invasion in lung adenocarcinoma through the microRNA-653/hexokinase 2 (HK2) axis

Wang, Shaobin; Zhang, Hao; Xia, Lixia; Lan, Fen

doi:10.1080/21655979.2021.2000743

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The findings of this study on the function of hsa_circ_0000018 in LA are consistent with those of a previous study on its function in colon cancer, suggesting that a molecular marker targeting hsa_circ_0000018 may also be developed for the diagnosis of LA. Additionally, many studies have shown that circRNAs can sponge the miRNA-mRNA axis, thereby participating in LA progression [ 10 , 24 , 25 ]. For example, hsa_circMMD_007 promotes LA progression by acting as an endogenous sponge for miR-197-3p [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression

Li,

Zhao,

et al. 2024

Cancer Biomarkers

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BACKGROUND: Circular RNAs (circRNAs) are critical regulators of lung adenocarcinoma (LA) progression. Although a molecular marker targeting hsa_circ_0000018 has been developed and used for diagnosing colon cancer, the role of this circRNA in LA progression has not been explored till now. OBJECTIVES: This study aimed to elucidate the role and regulatory mechanisms of hsa_circ_0000018 in LA progression. METHODS: LA tissues and corresponding adjacent non-tumor tissues were collected from 36 patients to confirm the levels of circRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). We also cultured two LA cell lines (A549, PC-9), and the human normal lung epithelial cell line BEAS-2B. Cell function experiments were conducted to assess malignancy in LA cells, including proliferation, migration, and invasion, following forced hsa_circ_0000018 expression. The correlation between hsa_circ_0000018, let-7f-5p, and family with sequence similarity 96 member A (FAM96A) was confirmed by using starBase (miRNA-circRNA interaction database), luciferase assay, and western blotting. RESULTS: Expression of hsa_circ_0000018 and FAM96A was reduced, whereas that of let-7f-5p was upregulated in LA. Cell function assays revealed that upregulation of hsa_circ_0000018 had a suppressive effect on the proliferation, migration, and invasion of LA cells. Additionally, hsa_circ_0000018 sponge binds let-7f-5p, resulting in upregulation of FAM96A expression. CONCLUSION: Our data reveal hsa_circ_0000018 as a tumor suppressor in LA that targets the let-7f-5p/FAM96A axis. Our findings enrich the known regulatory network of circRNAs in LA.

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Section: Discussionmentioning

confidence: 99%

Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression

Li,

Zhao,

et al. 2024

Cancer Biomarkers

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“…Delivery of miRNA mimics or sh-circRNA in vivo and in vitro to weaken HK2 expression levels may serve as a potential therapeutic strategy to decrease cancer cell proliferation and diminish the Warburg effect (aerobic glycolysis). 86 , 87 , 88 …”

Section: Non-coding Rnas In Glucose Metabolismmentioning

confidence: 99%

Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease

Zong¹,

Wang²,

Cheng³

et al. 2023

Molecular Therapy

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“…In prostate cancer, circ_0061140 targeted miR-1193 and facilitated tumor malignant development ( Wang et al, 2021a ). In lung adenocarcinoma, circ_0061140 regulated miR-653 expression and elevated hexokinase 2 levels, leading to promotion of hypoxia-mediated migration, invasion and glycolysis ( Wang et al, 2022d ). In ovarian cancer, silencing of circ_0061140 abolished FOXM1-induced metastasis and cell proliferation via sponging miR-370 ( Chen et al, 2018 ).…”

Section: Role Of Circrnas In Drug Resistancementioning

confidence: 99%

The role of circRNAs in regulation of drug resistance in ovarian cancer

Zhan,

Li,

Lin

et al. 2023

Front. Genet.

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Ovarian cancer is one of the female reproductive system tumors. Chemotherapy is used for advanced ovarian cancer patients; however, drug resistance is a pivotal cause of chemotherapeutic failure. Hence, it is critical to explore the molecular mechanisms of drug resistance of ovarian cancer cells and to ameliorate chemoresistance. Noncoding RNAs (ncRNAs) have been identified to critically participate in drug sensitivity in a variety of human cancers, including ovarian cancer. Among ncRNAs, circRNAs sponge miRNAs and prevent miRNAs from regulation of their target mRNAs. CircRNAs can interact with DNA or proteins to modulate gene expression. In this review, we briefly describe the biological functions of circRNAs in the development and progression of ovarian cancer. Moreover, we discuss the underneath regulatory molecular mechanisms of circRNAs on governing drug resistance in ovarian cancer. Furthermore, we mention the novel strategies to overcome drug resistance via targeting circRNAs in ovarian cancer. Due to that circRNAs play a key role in modulation of drug resistance in ovarian cancer, targeting circRNAs could be a novel approach for attenuation of chemoresistance in ovarian cancer.

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Circular RNA circ_0061140 accelerates hypoxia-induced glycolysis, migration, and invasion in lung adenocarcinoma through the microRNA-653/hexokinase 2 (HK2) axis

Cited by 6 publications

References 32 publications

Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression

Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression

Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease

The role of circRNAs in regulation of drug resistance in ovarian cancer

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