2019
DOI: 10.1002/jcp.28860
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Circular RNA circMAN2B2 facilitates glioma progression by regulating the miR‐1205/S100A8 axis

Abstract: The aim of this study was to research the mechanism of circMAN2B2 in the development of glioma. In our study, we found that circMAN2B2 has a higher expression in glioma tissues and cells, which was negatively related to the overall survival of glioma patients. The cell counting kit-8 assay, 5-ethynyl-2′-deoxyuridine labeling assay, transwell assay, and the nude mice assay indicated that knockdown of circMAN2B2 inhibited the cell proliferation, invasion, migration and decreased tumor size. In terms of mechanism… Show more

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Cited by 19 publications
(13 citation statements)
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“…Using CircInteractome prediction tool, we confirmed that circ-UBAP2 directly targeted miR-1205 and miR-382, which had been highlighted as tumor inhibitors in glioma. [11][12][13][14]21 Previous work uncovered the critical involvement of miR-1205 in many human tumors, including laryngeal squamous cell carcinoma and prostate cancer. 22,23 miR-382 was illuminated as an essential player in pancreatic cancer and breast cancer.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Using CircInteractome prediction tool, we confirmed that circ-UBAP2 directly targeted miR-1205 and miR-382, which had been highlighted as tumor inhibitors in glioma. [11][12][13][14]21 Previous work uncovered the critical involvement of miR-1205 in many human tumors, including laryngeal squamous cell carcinoma and prostate cancer. 22,23 miR-382 was illuminated as an essential player in pancreatic cancer and breast cancer.…”
Section: Discussionmentioning
confidence: 99%
“…9,10 miR-1205 and miR-382 were reported to be involved in the development of glioma. [11][12][13][14] Moreover, these reports demonstrated miR-1205 or miR-382 as a target of circRNAs in regulating glioma progression. However, it remains unknown whether the oncogenic effect of circ-UBAP2 on glioma is mediated by miR-1205 or miR-382.…”
Section: Introductionmentioning
confidence: 94%
“…Finally, circ_MAN2B2 regulates S100A8, which is another important protein involved in immunosuppressive states in sepsis [ 128 ].…”
Section: Circrnas Function In Sepsismentioning
confidence: 99%
“…For example, ectopic expression of miR-1205 significantly inhibited tumor growth in NSCLC mouse xenograft by targeting MDM4 and E2F1. In addition, multiple circRNA have been suggested to sponge miR-1205 in glioma (5759) and papillary thyroid cancer (60) to increase oncogenicity of these tumors. MiR-1207-5p inhibition induced stem phenotype and expression of stem cell markers, such as OCT4, C-MYC, and SOX2, in nasopharyngeal cancer (61).…”
Section: Plasmacytoma Variant Translocation 1 (Pvt1)mentioning
confidence: 99%