Circular RNA expression alterations in extracellular vesicles isolated from murine heart post ischemia/reperfusion injury

Ge, Xinyu; Meng, Qingshu; Zhuang, Rulin; Yuan, Dongsheng; Liu, Jing; Lin, Fang‐Yue; Fan, Huimin; Zhou, Xiaohui

doi:10.1016/j.ijcard.2019.08.024

Cited by 52 publications

(44 citation statements)

References 12 publications

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“…It has been demonstrated that the paracrine inhibitory impact of CPC on both cardiac fibroblast activation and collagen synthesis continues through cross-talk between cardiac fibroblasts and CPC-derived EVs (54). Thus, CPC-derived EVs ensure cardiac protection through paracrine output regarding cardiac myocytes that is attributable to decreased production of pro-healing cytokines and increased anti-inflammatory and anti-fibrotic microRNAs (55).…”

Section: Cardiomyocyte Progenitor Cell-derived Evsmentioning

confidence: 99%

Extracellular Endothelial Cell-Derived Vesicles: Emerging Role in Cardiac and Vascular Remodeling in Heart Failure

Berezin

2020

Front. Cardiovasc. Med.

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Extracellular vesicles play a pivotal role in numerous physiological (immune response, cell-to-cell cooperation, angiogenesis) and pathological (reparation, inflammation, thrombosis/coagulation, atherosclerosis, endothelial dysfunction) processes. The development of heart failure is strongly associated with endothelial dysfunction, microvascular inflammation, alteration in tissue repair, and cardiac and vascular remodeling. It has been postulated that activated endothelial cell-derived vesicles are not just transfer forms of several active molecules (such as regulatory peptides, coagulation factors, growth factors, active molecules, hormones that are embedded onto angiogenesis, tissue reparation, proliferation, and even prevention from ischemia/hypoxia), but are instead involved in direct myocardial and vascular damage due to regulation of epigenetic responses of the tissue. These responses are controlled by several factors, such as micro-RNAs, that are transferred inside extracellular vesicles from mother cells to acceptor cells and are transductors of epigenetic signals. Finally, it is not a uniform opinion whether different phenotypes of heart failure are the result of altered cardiac and vascular reparation due to certain epigenetic responses, which are yielded by co-morbidities, such as diabetes mellitus and obesity. The aim of the review is to summarize knowledge regarding the role of various types of extracellular endothelial cell-derived vesicles in the regulation of cardiac and vascular remodeling in heart failure.

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Section: Cardiomyocyte Progenitor Cell-derived Evsmentioning

confidence: 99%

Extracellular Endothelial Cell-Derived Vesicles: Emerging Role in Cardiac and Vascular Remodeling in Heart Failure

Berezin

2020

Front. Cardiovasc. Med.

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“…Recent studies have disclosed their function in inflammation regulation and confirmed their participation in the development of various diseases by regulating the polarization of macrophages (Lv et al., 2020; Wang et al., 2020; Yin et al., 2020). We previously demonstrated the significantly increased release of cardiac EVs post IR (Ge et al., 2019). However, the role of IR induced EVs (IR‐EVs) remains to be disclosed.…”

Section: Introductionmentioning

confidence: 96%

Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury

Meng

et al. 2021

J of Extracellular Vesicle

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Extracellular vesicles (EVs) curb important biological functions. We previously disclosed that ischemia‐reperfusion (IR) induces increased release of EVs (IR‐EVs) in the heart. However, the role of IR‐EVs in IR pathological process remains poorly understood. Here we found that adoptive transfer of IR‐EVs aggravated IR induced heart injury, and EV inhibition by GW4869 reduced the IR injury. Our in vivo and in vitro investigations substantiated that IR‐EVs facilitated M1‐like polarization of macrophages with increased expression of proinflammatory cytokines. Further, we disclosed the miRNA profile in cardiac EVs and confirmed the enrichment of miRNAs, such as miR‐155‐5p in IR‐EVs compared to EVs from the sham heart (S‐EVs). In particular, IR‐EVs transferred miR‐155‐5p to macrophages and enhanced the inflammatory response through activating JAK2/STAT1 pathway. Interestingly, IR‐EVs not only boosted the local inflammation in the heart, but even triggered systemic inflammation in distant organs. Taken together, we newly identify an IR‐EVs–miR‐155‐5p – M1 polarization axis in the heart post IR. The EVs derived from IR‐injured heart contribute to both local and systemic inflammation. Importantly, EV inhibition by GW4869 is supposed to be a promising therapeutic strategy for IR injury.

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“…In the context of kidney transplantation, a prospective cohort study has identified a cluster of miRNA that is associated with ischemia reperfusion injury [82]. In pre-clinical animal models, more studies are taking place to evaluate temporal-specific gene changes and expression profiles after IRI that will create a databank to explore novel therapeutic approaches to prevent organ injury [83,84].…”

Section: Organ Recovery and Processingmentioning

confidence: 99%

Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation

Fernández

Sánchez-Tarjuelo

Cravedi

et al. 2020

IJMS

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Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.

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Circular RNA expression alterations in extracellular vesicles isolated from murine heart post ischemia/reperfusion injury

Cited by 52 publications

References 12 publications

Extracellular Endothelial Cell-Derived Vesicles: Emerging Role in Cardiac and Vascular Remodeling in Heart Failure

Extracellular Endothelial Cell-Derived Vesicles: Emerging Role in Cardiac and Vascular Remodeling in Heart Failure

Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury

Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation

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