Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET

Jiang, Weidong; Wen, Dacheng; Gong, Lulu; Wang, Yu; Liu, Zefeng; Yin, Fangying

doi:10.1016/j.bbrc.2018.04.041

Cited by 47 publications

(32 citation statements)

References 33 publications

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“…PIK3CA, AKT1, MYC, JUN, SMAD4, and SRC were shown as hub target genes as they have more counts of interacting protein. Among the 87 DECs identified in our study, four up-regulated circRNAs, including hsa_circ_0000 673, hsa_circRNA_0072088, hsa_circ_0009910, and hsa_circ_0067934, have been reported to play important roles in the progression of different cancers, such as HCC, gastric cancer (GC), colorectal cancer (CRC), and esophageal squamous cell carcinoma (ESCC) [35][36][37][38][39][40]. Two circRNAs, hsa_circ_0000673 and hsa_circRNA_0072088, were up-regulated in HCC and lung cancer, separately, and play tumorpromoting roles by modulating miR-767-3p/SET axis and miR-4302/znf121/MYC axis, respectively [35,37].…”

Section: Discussionmentioning

confidence: 89%

Circular RNA Signature in Hepatocellular Carcinoma

Qiu¹,

Wang²,

Ge³

et al. 2019

J. Cancer

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Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. Circular RNAs (circRNAs) are a new class of endogenous functional non-coding RNAs (ncRNAs), and have been demonstrated to play important roles in the development of HCC. This study aimed to explore the significance of circRNAs in HCC progression. HCC-associated circRNA expression profiles GSE94508 and GSE97332 were downloaded from the Gene Expression Omnibus database (GEO), and 87 differentially expressed circRNAs (DECs) between HCC tissues and paired non-cancer tissues were identified, including 76 up-regulated and 11 down-regulated circRNAs. Gene ontolog (GO) and pathway analyses of the host genes of these DECs suggested that these host genes were enriched in cell adhesion, cytosol, and protein binding, and were associated with tight junction and Wnt signaling pathways. CircRNA-miRNA interaction prediction identified 20 miRNAs that predispose to interact with DECs. Among these, four essential miRNAs, hsa-miR-7-5p, hsa-miR-145-5p, hsa-miR-203a-3p, and hsa-miR-192-5p, were reported to play pivotal roles in HCC progression by targeting multiple genes. Pathway analysis suggested that putative target genes of these essential miRNAs were involved in HCC-associated signaling pathways, such as Wnt, TGF-β, and Ras; whereas protein-protein network (PPI) analysis demonstrated that some validated target genes of these miRNAs, such as PIK3CA, AKT1, MYC, JUN, SMAD4, and SRC, were hub target genes as they have more counts of interacting protein. In the meantime, the deregulation of some DECs was validated in HCC cell line HepG2 compared with normal liver cell line L02 by quantitative real-time polymerase chain reaction (qRT-PCR) and the Sanger sequencing. This study identified a set of DECs in HCC, and provided a comprehensive understanding of the roles of these DECs in HCC progression.

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Section: Discussionmentioning

confidence: 89%

Circular RNA Signature in Hepatocellular Carcinoma

Qiu¹,

Wang²,

Ge³

et al. 2019

J. Cancer

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“…There is mounting evidence to indicate that circRNAs, through the mechanism of competitive endogenous RNAs (ceRNAs), modulate the function of miRNAs [10,24,43]. CircRNAs can absorb miRNAs, which through the way impact post-transcriptional regulation [44][45][46]. Wei et al reported that circLMO7 regulates the differentiation and survival of myoblasts in cattle through sponging miR-378a-3p [28].…”

Section: Discussionmentioning

confidence: 99%

CircRNA Expression Profile during Yak Adipocyte Differentiation and Screen Potential circRNAs for Adipocyte Differentiation

Zhang

Guo

Pei

et al. 2020

Genes

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The yak (Bos grunniens) is subjected to nutritional deficiency during the whole winter grazing season; deciphering the adipose metabolism and energy homeostasis under cold and nutrients stress conditions could be a novel way to understand the specific mechanism of energy metabolism. Circular RNAs (circRNAs) have elucidated that they play a key role in many biological events, but the regulatory function of adipose development remains mostly unknown. Therefore, the expression pattern of circRNAs were identified for the first time during yak adipocyte differentiation to gain insight into their potential functional involvement in bovine adipogenesis. We detected 7203 circRNA candidates, most of them contained at least two exons, and multiple circRNA isoforms could be generated from one parental gene. Analysis of differential expression circRNAs displayed that 136 circRNAs were differentially expressed at day 12 (Ad) after adipocyte differentiation, compared with the control at day 0 (Pread 0), while 7 circRNAs were detected on day 2. Sanger sequencing validated that six circRNAs had head-to-tail junction, and quantitative real-time PCR (qPCR) results revealed that the expression patterns of ten circRNAs were consistent with their expression levels from RNA-sequencing (RNA-seq) data. We further predicted the networks of circRNA-miRNA-gene based on miRNAs sponging by circRNAs, in which genes were participated in the adipocyte differentiation-related signaling pathways. After that, we constructed several adipocyte differentiation-related ceRNAs and revealed six circRNAs (novel_circ_0009127, novel_circ_0000628, novel_circ_0011513, novel_circ_0010775, novel_circ_0006981 and novel_circ_0001494) were related to adipogenesis. Furthermore, we analyzed the homology among yak, human and mouse circRNAs and found that 3536 yak circRNAs were homologous to human and mouse circRNAs. In conclusion, these findings provide a solid basis for the investigation of yak adipocyte differentiation-related circRNAs and serve as a great reference to study the energy metabolism of high-altitude animals.

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“…Moreover, circRNAs are highly conserved among species [106]. To date, multiple circRNAs involved in the regulation of digestive system cancer progression have been by in vivo and in vitro experiments [68,107]. A previous study suggested that circRNAs offer new opportunities to design innovative therapeutic strategies for cancer treatment [106].…”

Section: Therapeutic Potential Of Circrnasmentioning

confidence: 99%

“…The circRNA-pcDNA3.1 overexpression vector can then be transfected into digestive system cancer cell lines [40]. Next, those transfected cell lines are injected into a xenograft nude mouse model to test the GOF of circRNAs in an animal model [46,67,68,72,73,75]. On the other hand, small interfering RNAs (siRNAs) have been designed for the junction of circRNAs and transfected into digestive system cancer cell lines to examine the LOF of circRNAs [23].…”

Section: Function and Mechanism Of Circrnamentioning

confidence: 99%

The Regulatory Functions of Circular RNAs in Digestive System Cancers

Yuan

Yuán

et al. 2020

Cancers

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Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer.

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Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET

Cited by 47 publications

References 33 publications

Circular RNA Signature in Hepatocellular Carcinoma

Circular RNA Signature in Hepatocellular Carcinoma

CircRNA Expression Profile during Yak Adipocyte Differentiation and Screen Potential circRNAs for Adipocyte Differentiation

The Regulatory Functions of Circular RNAs in Digestive System Cancers

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