Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non–Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2

Geng, Yi; Bao, Yongping; Zhang, Wei; Deng, Lili; Su, Dongju; Zheng, Hongyan

doi:10.1158/1541-7786.mcr-19-0998

Cited by 47 publications

(19 citation statements)

References 29 publications

(35 reference statements)

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“…Mechanistically, circPUM1 could sponge miR-326 to promote expression of its downstream proteins, Bcl-2 and cyclin D1 (181). Furthermore, these studies also indicated that knockdown or silencing hsa_circ_0014130, circPVT1 and circPUM1 inhibited in vivo lung cancer tumorigenesis in subcutaneous xenograft mouse models (179)(180)(181).…”

Section: Signal Transducer and Activator Of Transcription (Stat) Proteinsmentioning

confidence: 88%

“…Furthermore, several researches also identified the effects of circRNAs on tumorigenesis in in vivo studies. For example, Geng et al observed that hsa_circ_0014130 had oncogenic roles in NSCLC, and functioned as a ceRNA of miR-136-5p, to activate Bcl-2 which inhibited NSCLC apoptosis ( 179 ). Qin et al showed that circPVT1 promoted NSCLC progression by regulating the miR-497/Bcl-2 axis, and inhibiting apoptosis ( 180 ).…”

Section: The Role Of Circrnas In Lung Cancermentioning

confidence: 99%

See 1 more Smart Citation

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives

Chen

Zhang

et al. 2021

Front. Oncol.

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Globally, lung cancer is the most commonly diagnosed cancer and carries with it the greatest mortality rate, with 5-year survival rates varying from 4–17% depending on stage and geographical differences. For decades, researchers have studied disease mechanisms, occurrence rates and disease development, however, the mechanisms underlying disease progression are not yet fully elucidated, thus an increased understanding of disease pathogenesis is key to developing new strategies towards specific disease diagnoses and targeted treatments. Circular RNAs (circRNAs) are a class of non-coding RNA widely expressed in eukaryotic cells, and participate in various biological processes implicated in human disease. Recent studies have indicated that circRNAs both positively and negatively regulate lung cancer cell proliferation, migration, invasion and apoptosis. Additionally, circRNAs could be promising biomarkers and targets for lung cancer therapies. This review systematically highlights recent advances in circRNA regulatory roles in lung cancer, and sheds light on their use as potential biomarkers and treatment targets for this disease.

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Section: Signal Transducer and Activator Of Transcription (Stat) Proteinsmentioning

confidence: 88%

Section: The Role Of Circrnas In Lung Cancermentioning

confidence: 99%

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives

Chen

Zhang

et al. 2021

Front. Oncol.

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“…Several circRNAs have been found to control cell cycle events and gene expression in NSCLC by sponging miRNA [ 36 – 38 ]. In some instances, circRNA have acted as tumor suppressors, for instance, Hsa_circ_0002483 was found to inhibit NSCLC progression and enhance Taxol sensitivity by sponging targeting miR-182-5p [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527

Zhang

Yang

et al. 2021

Cell Death Dis

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The relationship between circular RNA (circRNA) and cancer stem cells (CSCs) is uncertain. We have investigated the combined influence of CSCs, circRNA (hsa_circ_0003222), and immune checkpoint inhibitors in NSCLC progression and therapy resistance. We constructed lung CSCs (LCSCs; PC9 and A549). The effects of hsa_circ_0003222 in vitro were determined by cell counting, colony and sphere formation, and Transwell assays. A tumor xenograft model of metastasis and orthotopic model were built for in vivo analysis. We found that hsa_circ_0003222 was highly expressed in NSCLC tissues and LCSCs. Higher levels of hsa_circ_0003222 were associated with the stage, metastasis, and survival rate of patients with NSCLC. Reduced levels of hsa_circ_0003222 decreased tumor cell proliferation, migration, invasion, stemness-like properties, and chemoresistance. The silencing of hsa_circ_0003222 was found to downregulate PHF21B expression and its downstream, β-catenin by relieving the sponging effect of miR-527. Moreover, silencing hsa_circ_0003222 alleviated NSCLC resistance to anti-programmed cell death-ligand 1 (PD-L1)-based therapy in vivo. Our data demonstrate the significant role of hsa_circ_0003222 in NSCLC cell stemness-like properties. The manipulation of circRNAs in combination with anti-PD-L1 therapy may alleviate NSCLC stemness and progression.

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“…To focus on the role of circ_0044516 in lung cancer, potential target miRNAs were predicted and miR-136 was identified. Circ_0014130 can reduce lung cancer cell apoptosis by sponging miR-136-5p and enhancing BCL2 [ 32 ]. miR-136-5p is downregulated in patients with LUSC [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development

Chen

et al. 2021

Journal of Immunology Research

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Circular RNA (circRNA) is a type of noncoding RNA that can interact with miRNAs to regulate gene expression. However, little is known concerning circRNA, which is crucial in the pathogenesis of lung cancer. To date, limited studies have explored the role of circ_0044516 in lung cancer progression. Recently, we observed that circ_0044516 expression levels were obviously elevated in lung cancer tissues and cells. A549 and SPCA1 cells were transfected with circ_0044516 siRNA. We observed that knockdown of circ_0044516 dramatically repressed cell proliferation, increased cell apoptosis, and repressed the cell cycle. Moreover, A549 and SPCA1 cell migration and invasion abilities were greatly repressed by circ_0044516 siRNA. Due to accumulating evidence demonstrating the vital role of cancer stem cells, their mechanism of involvement has drawn increasing attention in tumor progression and metastasis research. We also found that cancer stem cell properties were restrained by silencing circ_0044516 in A549 and SPC-A1 cells. Moreover, in vivo xenograft experiments showed that circ_0044516 downregulation reduced tumor growth. Mechanistically, in lung cancer and using bioinformatics, we demonstrated that circ_0044516 sponges miR-136 targeting MAT2A. Furthermore, rescue assays were carried out to identify that circ_0044516 modulates cell proliferation, invasion, and stemness by regulating miR-136 and MAT2A in lung cancer. In summary, our study revealed that the circ_0044516/miR-136/MAT2A axis is involved in lung cancer progression. Our findings may provide novel targets for diagnosis and therapeutic intervention in lung cancer patients.

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Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non–Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2

Cited by 47 publications

References 29 publications

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives

hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527

Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development

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