Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Liu, Zihao; Zhou, You; Liang, Gehao; Ling, Yun; Tan, Weige; Tan, Li Kuo; Andrews, Robert; Zhong, Wenjing; Zhang, Xuanxuan; Song, Erwei; Gong, Chang

doi:10.1038/s41419-018-1287-1

Cited by 265 publications

(179 citation statements)

References 34 publications

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“…Circular RNA hsa_circ_001783 is upregulated in BC cells and tissues. The role of this circRNA is confirmed in BC progression through sponging miR‐200c‐3p, which is related by poor prognosis (Liu et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Circular RNA; a new biomarker for breast cancer: A systematic review

Jahani

Nazeri

Majidzadeh‐A

et al. 2020

Journal Cellular Physiology

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Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell‐type and stage‐specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.

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Section: Resultsmentioning

confidence: 99%

Circular RNA; a new biomarker for breast cancer: A systematic review

Jahani

Nazeri

Majidzadeh‐A

et al. 2020

Journal Cellular Physiology

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“…7 A plenty of circRNAs have been identified by RNA-seq data in primary breast cancer, and a few of them have been suggested as important predictors, such as circCNOT2 and CREBBP. 9 Additionally, a circRNA circIRAK3 also acts as a promoter of breast cancer metastasis by sponging miR-3607. 9 Additionally, a circRNA circIRAK3 also acts as a promoter of breast cancer metastasis by sponging miR-3607.…”

Section: Introductionmentioning

confidence: 99%

“…8 Another circRNA hsa_circRNA_001783 has been reported to accelerate breast cancer progression by functioning as a sponge of miR-200c-3p. 9 Additionally, a circRNA circIRAK3 also acts as a promoter of breast cancer metastasis by sponging miR-3607. 10 miRNAs are non-coding RNA molecules that could mediate cell differentiation and survival.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA‐328‐3p‐mediated inhibition of COL1A1

Liu

et al. 2020

J Cellular Molecular Medi

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Circular RNAs (circRNAs) are a group of non-coding RNAs implicated in the pathogenesis of cancer progression, which exert their functions via regulation of microRNAs (miRNAs) and genes. The present study uses gain-and loss-of-function approaches to evaluate the functions of hsa_circRNA_002178 in angiogenesis along with energy metabolism and underlying downstream signals. The expression pattern of hsa_cir-cRNA_002178 in clinical breast cancer tissues and its association with prognosis were characterized at first. Next, the energy metabolism and angiogenesis as well as cell viability were evaluated when the expression of hsa_circRNA_002178 in breast cancer cells was knocked down by siRNA. The interaction between hsa_circRNA_002178 and its downstream miR-328-3p was identified, followed by the analysis of their functions in regulation of breast cancer cellular behaviours. The target gene of miR-328-3p was predicted and verified, followed by identifying its role in the breast cancer progression. Higher expression of hsa_circRNA_002178 shared an association with worse prognosis in breast cancer. The inhibition of hsa_circRNA_002178 resulted in reductions in cell viability, energy metabolism and tube formation ability.Hsa_circRNA_002178 could competitively bind to miR-328-3p and down-regulated its expression. Restoration of miR-328-3p eliminated the tumour-promoting effects of hsa_circRNA_002178. COL1A1, as a target of miR-328-3p, could be up-regulated by overexpression of hsa_circRNA_002178. In vivo experiments further confirmed the inhibition of tumour growth and inflammation by silencing hsa_circRNA_002178 or up-regulating miR-328-3p. Taken together, hsa_circRNA_002178 is highlighted as a promising target for breast cancer due to the anti-tumour effects achieved by silencing hsa_circRNA_002178. K E Y W O R D S angiogenesis, breast cancer, circular RNA, COL1A1, energy metabolism, Hsa_ circRNA_002178, MicroRNA-328-3p Additional supporting information may be found online in the Supporting Information section. How to cite this article: Liu T, Ye P, Ye Y, Lu S, Han B. Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.

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“…ZFP36 was a downregulated gene in BC, and upregulation of ZFP36 inhibited transactivation of ERα, cell proliferation, as well as the capacity to form new tumors 18,30 . It was noted that circRNAs played critical functions during tumor progression by binding to miRs and miRs affected behaviors of malignant cells by regulating posttranscriptional gene expression 11,31 . In our study, the RNA crosstalk among circRNA_000554, miR‐182, and ZFP36 in BC was studied.…”

Section: Discussionmentioning

confidence: 90%

Circular RNA 000554 represses epithelial‐mesenchymal transition in breast cancer by regulating microRNA‐182/ZFP36 axis

Mao

Cao

et al. 2020

FASEB j.

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Increasing evidence indicates that circular RNAs (circRNAs) play a crucial role in regulating microRNAs (miRs) and mRNAs during breast cancer (BC) progression. Based on the in silico analysis of circRNA/miR/mRNA in BC, we aim to define an important role of circRNA_000554 in BC in relation to miR‐182 and zinc finger protein 36 (ZFP36). Low expression of circRNA_000554 and ZFP36, and high miR‐182 expression were determined in the clinical BC tissues. CircRNA_000554 acted as a sponge of miR‐182, and miR‐182 directly targeted ZFP36. After that, in order to evaluate the effects of circRNA_000554, miR‐182, and ZFP36 on cellular process, we evaluated in vitro epithelial‐mesenchymal transition (EMT) and in vivo tumor growth after delivering a series of overexpression plasmids, mimic, inhibitor, or shRNAs into BC cells. Increasing circRNA_000554 suppressed EMT, cell invasion and migration during BC by depleting miR‐182 and increasing ZFP36. The inhibitory effect of circRNA_000554 on tumor growth was validated in vivo. Taken together, the present study confirms that circRNA_000554 functioned as an inhibitor of EMT in BC and suggests a molecular mechanism that circRNA_000554 bound to miR‐182 to upregulate ZFP36 in this process.

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Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Cited by 265 publications

References 34 publications

Circular RNA; a new biomarker for breast cancer: A systematic review

Circular RNA; a new biomarker for breast cancer: A systematic review

Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA‐328‐3p‐mediated inhibition of COL1A1

Circular RNA 000554 represses epithelial‐mesenchymal transition in breast cancer by regulating microRNA‐182/ZFP36 axis

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