Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Zhang, Mei‐Yin; Xia, Bairong; Xu, Ye; Zhang, Yongjian; Xu, Jin; Lou, Ge

doi:10.1080/21691401.2019.1593999

Cited by 74 publications

(60 citation statements)

References 27 publications

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“…For instance, circPLEKHM3 was down-regulated in OC and identified as a tumor inhibitor by the miR-9/BRCA1/DNAJB6/KLF4/ AKT1 axis; 9 Guan et al illuminated that circPUM1 was up-regulated and improved the tumorigenesis of OC via targeting miR-615-5p or miR-6753-5p. 10 We noticed the up-regulation of circ_0025033 in OC tissues in a recent study, 11 while the report about its biological function in OC has not been published.…”

Section: Introductionmentioning

confidence: 99%

<p>Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis</p>

Cheng¹,

Wang²,

Tian³

et al. 2020

CMAR

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Background: Circular RNAs (circRNAs) are significant molecular targets in various types of human cancers. The functional mechanism of circRNA_0025033 (circ_0025033) in ovarian cancer (OC) was discussed in the current report. Methods: The quantitative real-time polymerase chain reaction (qRT-PCR) was used for determining the circ_0025033 and microRNA-330-5p (miR-330-5p) levels. Cell Counting Kit-8 (CCK-8) and transwell assays were separately exploited to analyze cell viability and migration/invasion. Cell apoptosis was assessed using flow cytometry. The protein levels of epithelial-mesenchymal transition (EMT)-related makers and kallikrein-related peptidase 4 (KLK4) were measured by Western blotting. The target combination was confirmed by dualluciferase reporter assay, RNA immunoprecipitation (RIP) and RNA pull-down assays. And the effect of circ_0025033 on OC in vivo was explored via xenograft tumor assay. Results: Circ_0025033 was overexpressed in OC tissues and cells. Circ_0025033 knockdown inhibited OC cell viability, migration, invasion and EMT while expedited apoptosis. MiR-330-5p was a target of circ_0025033 and circ_0025033 regulated OC cellular behaviors by sequestering miR-330-5p. Moreover, miR-330-5p targeted KLK4 and circ_0025033 affected the KLK4 expression by sponging miR-330-5p. And miR-330-5p functioned as a tumor inhibitor in OC via targeting KLK4. In vivo, circ_0025033 promoted OC growth by the miR-330-5p/KLK4 axis. Conclusion: This study demonstrated that circ_0025033 contributed to the progression of OC via the miR-330-5p/KLK4 axis and might be a candidate target in the identification and treatment of OC.

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Section: Introductionmentioning

confidence: 99%

<p>Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis</p>

Cheng¹,

Wang²,

Tian³

et al. 2020

CMAR

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“…Studies also found that circRNAs regulated the malignant biological behavior of ovarian cancer cells [16]. For example, circEXOC6B and circN4BP2L2 may act as novel prognostic biomarkers in patients with epithelial ovarian cancer [17], circ_0051240 promotes cell proliferation, migration and invasion in ovarian cancer [18], and circ-HIPK3 is an important regulator of ovarian cancer progression [19]. Besides, our study found that circRNA-UBAP2 was highly expressed in ovarian cancer tissues and cell lines.…”

Section: Discussionmentioning

confidence: 53%

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

Deng

et al. 2020

Preprint

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Abstract Objective: circular RNAs (circRNAs) have been reported to be essential regulators of multiple malignant cancers. However, the functions of circRNAs in ovarian cancer need to be further explored. The aim of our study is to explore the role of circRNA-UBAP2 in ovarian cancer and its mechanism. Results: circRNA-UBAP2 was upregulated in ovarian cancer tissues and cell lines. Knockdown of circRNA-UBAP2 inhibited cell proliferation and promoted cell apoptosis, but circRNA-UBAP2 overexpressed got opposite results. In addition, circRNA-UBAP2 targeted miR-382-5p and downregulated its expression, PRPF8 was a target gene of miR-382-5p. Furthemore, circRNA-UBAP2/miR-382-5p/PRPF8 axis affected the proliferation, apoptosis and cell cycle of ovarian cancer through the mechanism of competing endogenous RNAs (ceRNA). Conclusion: circRNA-UBAP2 acted as a ceRNA to sponged miR-382-5p, increased the expression level of PRPF8, and prompted proliferation and inhibited apoptosis in ovarian cancer cells.

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“…MiR-196a-5p also interacts directly with the 3'UTR of ZMYND11 and promotes the growth of GBM cells (35). Finally, miR-637 has been reported to be a tumor suppressor gene in diverse human cancers, such as gastric (36), ovarian (37) and colorectal cancers (38). Results in human glioma are consistent with a function as a tumor suppressor; expression levels of miR-637 were significantly reduced in clinical glioma tissues compared with normal brain tissues (39).…”

Section: Discussionmentioning

confidence: 71%

LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM

Zheng

Kong

et al. 2020

Front. Oncol.

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Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Abstract: View related articles View Crossmark data Citing articles: 13 View citing articles Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Cited by 74 publications

References 27 publications

<p>Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis</p>

<p>Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis</p>

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM

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