Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis

Yang, Jing; Zhang, Xing; Cao, Jiacheng; Xu, Penghui; Chen, Zetian; Wang, Sen; Li, Bowen; Zhang, Lu; Xie, Li; Fang, Lang; Xu, Zekuan

doi:10.1038/s41419-021-04216-3

Cited by 49 publications

(39 citation statements)

References 42 publications

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“…The circRNA circRPL15 , up-regulated in GC tissues and correlated with short survival, enhances GC cell migration and invasion, and inhibits apoptosis by sequestering miR-502-3p from the OLFM4 mRNA to activate the STAT3 pathway [ 72 ]. A similar ceRNA mechanism also applies to circUBE2Q2 , which interacts with miR-370-3p to relieve the inhibitory effect on its target STAT3 in GC, promoting proliferation, glycolysis, and metastasis [ 73 ].…”

Section: Other Metastasis-related Pivotal Pathways or Targetsmentioning

confidence: 99%

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Wang

Zhang

Cao

et al. 2022

J Exp Clin Cancer Res

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Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields meaningful insights into potential biomarkers and therapeutic targets. Covalently closed circular RNAs (circRNAs) have emerged as crucial regulators in diverse human cancers including GC. Furthermore, accumulating evidence has demonstrated that circRNAs exhibit the dysregulated patterns in GC and have emerged as crucial regulators in GC invasion and metastasis. However, systematic knowledge regarding the involvement of circRNAs in metastatic GC remains obscure. In this review, we outline the functional circRNAs related to GC metastasis and drug resistance and discuss their underlying mechanisms, providing a comprehensive delineation of circRNA functions on metastatic GC and shedding new light on future therapeutic interventions for GC metastases.

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Section: Other Metastasis-related Pivotal Pathways or Targetsmentioning

confidence: 99%

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Wang

Zhang

Cao

et al. 2022

J Exp Clin Cancer Res

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“…Although the function of CircUBE2Q2 to promote differentiation of cattle MuSCs was identified in this study, the modification pathways and biological processes involved in its ability to regulate muscle cell differentiation need to be further elucidated. Interestingly, previous reports claimed that circUBE2Q2 induced gastric cancer by promoting cell proliferation acceleration [ 50 ]. This may be due to factors of different species, cells, and sequences that cause differences in the function of circUBE2Q2.…”

Section: Discussionmentioning

confidence: 99%

CircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development

et al. 2022

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Background The growth and development of muscle stem cells (MuSCs) are significant events known to affect muscle plasticity, disease, meat production, and meat quality, which involves the types and functions of mRNA and non-coding RNA. Here, MuSCs were cultured from Guangxi fetal cattle. RNA sequencing was used to analyze the RNA expression of mRNA and non-coding RNAs during the cell proliferation and differentiation phases. Results Two thousand one hundred forty-eight mRNAs and 888 non-coding RNAs were differentially expressed between cell proliferation and differentiation phases, including 113 miRNAs, 662 lncRNAs, and 113 circRNAs. RT-qPCR verified the differential expression levels of mRNAs and non-coding RNAs, and the differentially expressed circUBE2Q2 was subsequently characterized. Expression profile analysis revealed that circUBE2Q2 was abundant in muscle tissues and intramuscular fat. The expression of cricUBE2Q2 was also significantly upregulated during MuSCs myogenic differentiation and SVFs adipogenic differentiation and decreased with age in cattle muscle tissue. Finally, the molecular mechanism of circUBE2Q2 regulating MuSCs function that affects skeletal muscle development was investigated. The results showed that circUBE2Q2 could serve as a sponge for miR-133a, significantly promoting differentiation and apoptosis of cultured MuSCs, and inhibiting proliferation of MuSCs. Conclusions CircUBE2Q2 is associated with muscle growth and development and induces MuSCs myogenic differentiation through sponging miR-133a. This study will provide new clues for the mechanisms by which mRNAs and non-coding RNAs regulate skeletal muscle growth and development, affecting muscle quality and diseases.

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“…Knockdown of circUBE2Q2 inhibited GC cell proliferation, invasion, tumorigenicity, and increased autophagy through the circUBE2Q2/miR-370-3p/STAT3 axis. 63 It is reported that circ0032821 induced the proliferation, EMT, migration, and invasion and inhibited autophagy of GC cells by activating the MEK1/ERK1/2 signaling pathway. 64 CircKIAA0907 is reported to be downregulated in GC.…”

Section: Autophagy-related Noncoding Rna and Gastric Cancermentioning

confidence: 99%

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Lü¹,

Liang²,

Zhang³

et al. 2022

CMAR

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Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.

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Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis

Cited by 49 publications

References 42 publications

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

CircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development

Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

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