Circular RNAs in metabolism and metabolic disorders

Zeng, Yanhua; Zheng, Zhoushun; Liu, Fengtao; Yi, Guanghui

doi:10.1111/obr.13220

Cited by 18 publications

(9 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high-fat diet can bring a variety of harms, such as inflammation, oxidative stress, and chronic diseases, etc. ( Yang et al, 2021 ; Zeng et al, 2021 ) High blood lipids are closely related to cardiovascular diseases, which can lead to myocardial infarction, atherosclerosis, and other serious diseases ( Li et al, 2018 ; Wang et al, 2021 ). The heart is an important place for the uptake and utilization of fatty acids, and the study of the effect of high lipid on the heart is of great importance.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Conjugated Gold Nanoclusters as Perspective Therapeutics for Diabetic Cardiomyopathy

Wei

Zheng³

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

Accumulation of lipids in the myocardium contributes to the development of cardiac dysfunctions and various chronic diseases, such as diabetic cardiomyopathy (DCM). Curcumin (Cur) can relieve lipid accumulation problems, but its efficiency is limited by poor water solubility and biocompatibility. Herein, gold nanoclusters (AuNCs) were used to improve the efficiency of Cur, and the conjugates Curcumin-AuNCs (AuCur) were developed. In the treatment of high-fat-induced myocardial cell damage, we found that AuCur could effectively reduce intracellular lipid accumulation, the increase of reactive oxygen species (ROS), the increase of mitochondrial division, and the increase of apoptosis compared with Cur. AuCur decreased the expression of the peroxisome proliferator-activated receptors-α subtype (PPARα), and the therapeutic effect of AuCur was canceled when the expression of PPARα was enhanced. For the above reasons, AuCur treated the toxic effect of high lipid on cardiomyocytes by regulating PPARα, providing a new idea and method for the treatment of DCM.

show abstract

Section: Discussionmentioning

confidence: 99%

Curcumin Conjugated Gold Nanoclusters as Perspective Therapeutics for Diabetic Cardiomyopathy

Wei

Zheng³

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…141,142 circRNAs are involved in the process of metabolic diseases and have the potential to be as future therapeutics and disease biomarkers. 143…”

Section: Epigenetic Regulatory Mechanismsmentioning

confidence: 99%

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

Lin

et al. 2023

Sig Transduct Target Ther

129

View full text Add to dashboard Cite

Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others. The term ‘epigenetics’ was firstly proposed in 1942 and with the development of technologies, the exploration of epigenetics has made great progresses. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, and noncoding RNA (ncRNA), which exert different effects on metabolic diseases. Genetic and non-genetic factors, including ageing, diet, and exercise, interact with epigenetics and jointly affect the formation of a phenotype. Understanding epigenetics could be applied to diagnosing and treating metabolic diseases in the clinic, including epigenetic biomarkers, epigenetic drugs, and epigenetic editing. In this review, we introduce the brief history of epigenetics as well as the milestone events since the proposal of the term ‘epigenetics’. Moreover, we summarise the research methods of epigenetics and introduce four main general mechanisms of epigenetic modulation. Furthermore, we summarise epigenetic mechanisms in metabolic diseases and introduce the interaction between epigenetics and genetic or non-genetic factors. Finally, we introduce the clinical trials and applications of epigenetics in metabolic diseases.

show abstract

“…These dysregulated lncRNAs and circRNAs in lipid metabolic reprogramming (known as lipid-metabolic related lncRNAs and cir-cRNAs) not only support the demand of rapid ATP generation, biosynthesis of macromolecules and maintenance of appropriate redox status in cancer, but also promote cancer cells to disseminate to distal organs and resist to radiochemotherapy, even involving the mechanism of anti-ferroptosis. [12,18,101,102] In the following sections, we will summarize the lipid-metabolic related lncRNAs and circRNAs and their targets in lipid-metabolic reprogramming of cancer, analyze their multiple regulatory mechanisms and display their various relevant biological functions in detail (Figures 4-6, Tables 1-4).…”

Section: Lncrnas-circrnas Regulate the Rewiring Of Lipid Metabolism I...mentioning

confidence: 99%

LncRNAs‐circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers

Liu,

Jiao,

Zhao

et al. 2023

Advanced Science

View full text Add to dashboard Cite

As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is shown to support carcinogenesis, progression, distal metastasis, and chemotherapy resistance by generating ATP, biosynthesizing macromolecules, and maintaining appropriate redox status. Notably, increasing evidence confirms that lipid metabolic reprogramming is under the control of dysregulated non‐coding RNAs in cancer, especially lncRNAs and circRNAs. This review highlights the present research findings on the aberrantly expressed lncRNAs and circRNAs involved in the lipid metabolic reprogramming of cancer. Emphasis is placed on their regulatory targets in lipid metabolic reprogramming and associated mechanisms, including the clinical relevance in cancer through lipid metabolism modulation. Such insights will be pivotal in identifying new theranostic targets and treatment strategies for cancer patients afflicted with lipid metabolic reprogramming.

show abstract

Circular RNAs in metabolism and metabolic disorders

Cited by 18 publications

References 128 publications

Curcumin Conjugated Gold Nanoclusters as Perspective Therapeutics for Diabetic Cardiomyopathy

Curcumin Conjugated Gold Nanoclusters as Perspective Therapeutics for Diabetic Cardiomyopathy

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

LncRNAs‐circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers

Contact Info

Product

Resources

About