Circular RNAs in the Regulation of Oxidative Stress

Abstract

Oxidative stress caused by an imbalance between the production and elimination of reactive metabolites and free radicals can lead to the development of a variety of diseases. Over the past years, with the development of science and technology, circular RNA (circRNA) has been found to be closely associated with oxidative stress, which plays an important role in the process of oxidative stress. Currently, the understanding of circRNAs in the mechanism of oxidative stress is limited. In this review, we described the relationship between oxidative stress and circRNAs, the circRNAs related to oxidative stress, and the role of circRNAs in promoting or inhibiting the occurrence and development of diseases associated with the oxidative stress system.

Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

“…They display cell-specific and tissue-specific/developmental-stage-specific expression. Their biogenesis appears to be dissimilar to the canonical splicing of linear RNAs and is controlled by specific cis-acting elements and trans-acting factors [ 107 , 108 , 109 , 110 , 111 ]. CircRNAs act as regulators of diverse biological and pathological processes by sponging miRNAs and binding to RBP, which are, as mentioned above, regulators of splicing and transcription, modifiers of parental gene expression and regulators of protein translation, or by being translated into peptides in various diseases [ 107 , 108 , 109 , 110 , 111 ].…”

“…Their biogenesis appears to be dissimilar to the canonical splicing of linear RNAs and is controlled by specific cis-acting elements and trans-acting factors [ 107 , 108 , 109 , 110 , 111 ]. CircRNAs act as regulators of diverse biological and pathological processes by sponging miRNAs and binding to RBP, which are, as mentioned above, regulators of splicing and transcription, modifiers of parental gene expression and regulators of protein translation, or by being translated into peptides in various diseases [ 107 , 108 , 109 , 110 , 111 ]. CircRNAs have been detected in exosomes and body fluids, including human blood, saliva, and cerebrospinal fluids, showing that these exo-circRNAs can represent both disease biomarkers and novel therapeutic targets.…”

“…Specifically, exo-circRNAs can be used as biomarkers of OS because they are regulated by OS and induce ROS production and cause ROS-induced cellular death, cell apoptosis and inflammation. These features make circRNAs important regulators of diverse diseases, such as atherosclerosis and other diseases of the cardiovascular system, metabolic disease, and cancers [ 107 , 108 , 109 , 110 , 111 ].…”

“…Based on this concept, circRNAs might represent another effective therapeutic approach to OS. Controlling the expression of circRNAs in cardiovascular cells might permit the application of anti OS agents for significantly reducing the endothelial dysfunction and vascular inflammation associated with the onset of CVD (e.g., aneurysms) and metabolic diseases [ 107 , 108 , 109 , 110 , 111 ].…”

Adaptive Response of Thermophiles to Redox Stress and Their Role in the Process of dye Degradation From Textile Industry Wastewater

“…Some examples of genetic level oxidative stress regulations include transcriptional regulators (OxyR, PerR, etc.) ( Gao et al, 2020 ; Fasnacht and Polacek, 2021 ), Nrf2 ( Wang et al, 2017 ; Zhang Y. et al, 2021 ), tRNA methyl-transferase ( Jaroensuk et al, 2016 ), and genes encoding UvrABC system ( Hagi et al, 2018 ). The role of 2’-O-ribose tRNA methylation in the cell’s response to oxidative stress was investigated in Saccharomyces cerevisiae ( Endres et al, 2020 ).…”