Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk

Chiara, Tiziana Di; Argano, Christiano; Scaglione, Attilio; Corrao, Salvatore; Pinto, Antonio; Scaglione, Rosario

doi:10.1080/ac.70.1.3064591

Cited by 19 publications

(16 citation statements)

References 30 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given the well-known beneficial effect of adiponectin on several metabolic and vascular phenotypes [ 4 , 38 – 40 ], the intrinsic biological nature underlying such deleterious effect(s) is difficult to understand or even only to speculate; otherwise, we would not be talking of “paradoxical effect/association”. Having acknowledge this, some deleterious actions of adiponectin on processes possibly involved in atherogenesis, including stimulatory effect on secretion of pro-atherogenic cytokines [ 41 – 43 ] and angiogenesis [ 42 , 44 ], have been recently reported in specific cell types.…”

Section: Discussionmentioning

confidence: 99%

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

Moreno

Copetti

Fontana

et al. 2016

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundDespite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive predictor of cardiovascular mortality.MethodsA Mendelian randomization approach was used, in order to evaluate whether such counterintuitive association recognizes a cause-effect relationship. To this purpose, single nucleotide polymorphism rs822354 in the ADIPOQ locus which has been previously associated with serum adiponectin at genome-wide level, was used as an instrument variable. Our investigation was carried out in the Gargano Heart Study-prospective design, comprising 356 patients with type 2 diabetes, in whom both total and high molecular weight (HMW) adiponectin were measured and cardiovascular mortality was recorded (mean follow-up = 5.4 ± 2.5 years; 58 events/1922 person-year).ResultsThe A allele of rs822354 was associated with both total and HMW adiponectin [β (SE) = 0.10 (0.042), p = 0.014 and 0.17 (0.06), p = 0.003; respectively]. In a Poisson model comprising age, sex, smoking habits, BMI, HbA1c, total cholesterol, HDL-cholesterol, triglycerides, insulin therapy and hypertension, both rs822354 (IRR = 1.94, 95 % CI 1.23–3.07; p = 0.005), as well as the genetic equivalent of total adiponectin change (IRR = 1.07, 95 % CI 1.02–1.12; p = 0.003) were significantly associated with cardiovascular mortality. The observed genetic effect was significantly greater than that exerted by the genetic equivalent change of serum adiponectin (p for IRR heterogeneity = 0.012). In the above-mentioned adjusted model, very similar results were obtained when HMW, rather than total, adiponectin was used as the exposure variable of interest.ConclusionsOur data suggest that the paradoxical association between high serum adiponectin levels and increased cardiovascular mortality rate is based on a cause-effect relationship, thus pointing to an unexpected deleterious role of adiponectin action/metabolism on atherosclerotic processes.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

Moreno

Copetti

Fontana

et al. 2016

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…Chiara and cols. (33) showed that subjects with low adiponectin levels had a higher prevalence of obesity, MetS, DM and CVD.…”

Section: Discussionmentioning

confidence: 99%

The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

Tabak

Şimşek

Erdenen³

et al. 2017

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objective: We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). Subjects and methods: In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits. Results: While fasting plasma hsCRP, PTX-3, IL-33, irisin, RBP-4 concentrations were higher, adiponectin levels were lower in patients with MetS than in controls. A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Adiponectin levels were negatively associated with waist circumference, waist-hip ratio, PTX-3 and LDL. Conclusions: Although the precise mechanisms are still unclear, irisin, RBP-4, adiponectin and PTX-3 are hallmarks of the MetS, which is related to low-grade inflammation. It is conceivable that irisin and adiponectin might contribute to the development of MetS and may also represent novel MetS components. Future clinical studies are needed to confirm and extend these data. Arch Endocrinol Metab. 2017;61(6):515-23

show abstract

“…Среди них лептин ассоциирован с прогрессированием атеросклероза и худшим клиническим исходом, особенно у пациентов с ожирением, а адипонектин является сильным протективным фактором. Уровни адипонектина ассоциированы с эссенциальной гипертензией [82], риском развития CCЗ [19] и функцией сердца при бессимптомном диабете 2 типа [16]. Метаболическое воспаление может быть связано с изменением профиля циркулирующих адипокинов [131].…”

Section: биомаркеры атеросклерозаunclassified

Biomarkers of Cardiovascular Disease

Scherbak

Григорьевич²,

Лисовец

et al. 2019

Physical and rehabilitation medicine, medical rehabilitation

View full text Add to dashboard Cite

Inflammation, cardiac remodeling, and fibrosis are potentially important pathways in the pathogenesis of cardiovascular diseases. Complications of atherosclerosis are one of the leading causes of death in the world. Effective prevention of cardiovascular disease by adequate control of major cardiovascular risk factors can provide substantial public health gains. However, detection and control of major cardiovascular risk factors continues to be a major challenge because of poor awareness of an individual's status. A solution to this problem is important for an early identification and appropriate correction of cardiovascular risk factors. Atherosclerotic plaque development is regarded as a chronic inflammatory process which involves interactions between lipids, immune cells and the artery wall. Numerous evidence suggests that inflammation plays an important role in all stages of the atherosclerotic process. The study of associations of inflammatory biomarkers has led to the idea that the panel of inflammatory biomarkers can identify people at high risk of developing atherosclerosis and cardiovascular diseases when anti-inflammatory treatment can prevent further unfavorable events. The most common forms of cardiovascular diseases are caused by atherosclerosis, the progressive thinning of blood vessels due to accumulation of lipids within the arterial wall. While many factors are known to influence the development and progression of atherosclerosis, circulating levels of cholesterol and lipoprotein complexes are the most important risk factors and mediators of atherosclerotic disease. Key regulators of lipid metabolism and/or the development of atherosclerosis have diagnostic, prognostic and therapeutic potential for cardiovascular diseases.

show abstract

Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk

Abstract: ADPN might be considered a key component mediating the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk.

Cited by 19 publications

References 30 publications

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

Biomarkers of Cardiovascular Disease

Contact Info

Product

Resources

About