Circulating adiponectin levels in various malignancies: an updated meta-analysis of 107 studies

Wei, Tingcun; Ye, Peng; Peng, Xin; Wu, Li‐Ling; Yu, Guang-yan

doi:10.18632/oncotarget.8932

Cited by 57 publications

(48 citation statements)

References 127 publications

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“…However, an inverse correlation has been observed between adiponectin levels and progression of colon, breast, endometrial and prostate cancers [29][30][31]. Furthermore, circulating adiponectin levels have been found to be significantly lower in patients with cancer compared with healthy controls [45]. Thus, adiponectin might also play a role in anti-cancer functions.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells

et al. 2016

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Chondrosarcoma is the second most frequently occurring type of bone malignancy characterized by distant metastatic propensity. Vascular endothelial growth factor-C (VEGF-C) is the major lymphangiogenic factor, and makes crucial contributions to tumour lymphangiogenesis and lymphatic metastasis. Adiponectin is a protein hormone secreted predominantly by differentiated adipocytes. In recent years, adiponectin has also been indicated as facilitating tumorigenesis, angiogenesis and metastasis. However, the effect of adiponectin on VEGF-C regulation and lymphangiogenesis in chondrosarcoma has remained largely a mystery. In the present study, we have shown a clinical correlation between adiponectin and VEGF-C, as well as tumour stage, in human chondrosarcoma tissues. We further demonstrated that adiponectin promoted VEGF-C expression and secretion in human chondrosarcoma cells. The conditioned medium from adiponectin-treated cells significantly induced tube formation and migration of human lymphatic endothelial cells. In addition, adiponectin knock down inhibited lymphangiogenesis in vitro and in vivo We also found that adiponectin-induced VEGF-C is mediated by the calmodulin-dependent protein kinase II (CaMKII), AMP-activated protein kinase (AMPK) and p38 signaling pathway. Furthermore, the expression of miR-27b was negatively regulated by adiponectin via the CaMKII, AMPK and p38 cascade. The present study is the first to describe the mechanism of adiponectin-promoted lymphangiogenesis by up-regulating VEGF-C expression in chondrosarcomas. Thus, adiponectin could serve as a therapeutic target in chondrosarcoma metastasis and lymphangiogenesis.

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Section: Discussionmentioning

confidence: 99%

Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells

et al. 2016

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“…Weight control is likely to reduce the incident risk of thirteen cancers which have been linked to obesity (Renehan et al, 2008), although the role of weight management after diagnosis on the outcome of obesity related cancers is not known (WCRF, 2014; Goodwin et al, 2015). Surrogate evidence that IF may reduce cancer risk can be derived from its effects on a number of cancer risk biomarkers such as insulin, cytokines, and the inflammation-related molecules leptin and adiponectin, which are thought to mediate the effects of adiposity and excessive energy intake on the development and growth of cancers in humans (Hursting et al, 2012; Wei et al, 2016). …”

Section: If In Humansmentioning

confidence: 99%

Impact of intermittent fasting on health and disease processes

Mattson

Longo

Harvie

2017

Ageing Research Reviews

865

621

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Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. Because animals, including humans, evolved in environments where food was relatively scarce, they developed numerous adaptations that enabled them to function at a high level, both physically and cognitively, when in a food-deprived/fasted state. Intermittent fasting (IF) encompasses eating patterns in which individuals go extended time periods (e.g., 16–48h) with little or no energy intake, with intervening periods of normal food intake, on a recurring basis. We use the term periodic fasting (PF) to refer to IF with periods of fasting or fasting mimicking diets lasting from 2 to as many as 21 or more days. In laboratory rats and mice IF and PF have profound beneficial effects on many different indices of health and, importantly, can counteract disease processes and improve functional outcome in experimental models of a wide range of age-related disorders including diabetes, cardiovascular disease, cancers and neurological disorders such as Alzheimer’s disease Parkinson’s disease and stroke. Studies of IF (e.g., 60% energy restriction on 2 days per week or every other day), PF (e.g., a 5 day diet providing 750–1100 kcal) and time-restricted feeding (TRF; limiting the daily period of food intake to 8 h or less) in normal and overweight human subjects have demonstrated efficacy for weight loss and improvements in multiple health indicators including insulin resistance and reductions in risk factors for cardiovascular disease. The cellular and molecular mechanisms by which IF improves health and counteracts disease processes involve activation of adaptive cellular stress response signaling pathways that enhance mitochondrial health, DNA repair and autophagy. PF also promotes stem cell-based regeneration as well as long-lasting metabolic effects. Randomized controlled clinical trials of IF versus PF and isoenergetic continuous energy restriction in human subjects will be required to establish the efficacy of IF in improving general health, and preventing and managing major diseases of aging.

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“…On the other hand, uric acid can activate the dendritic cell to mature and strengthen the responses from CD8+ T cells, which have been regarded as a mechanism through the immune system in response to tumors . Additionally, factors such as adiponectin, leptin, and C‐reactive protein are also involved in uric acid‐related inflammation that is associated with cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

Lin

Liao

Chen

et al. 2019

Clinical Laboratory Analysis

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BackgroundPrevious studies have revealed that the single nucleotide polymorphism (SNP) rs2188380 was identified as a novel locus of gout. Interestingly, gout resulting from high serum uric acid (SUA) was also identified to be associated with the risk of breast cancer (BC). We hypothesized that maybe there was a relationship between rs2188380 and the risk of BC. Therefore, our study was conducted to investigate whether this novel gout‐related SNP (rs2188380) was associated with BC risk as well as the clinical and pathological characteristics in the southwest Chinese population.Materials and methodsWe performed a case‐control study including 104 breast cancer patients and 112 healthy controls to investigate whether rs2188380 is associated with BC risk in the southwest Chinese population. The genotyping was performed by the SNP scan method. General characteristics and clinicopathological characteristics of tumors were also included in the analysis. The statistical evaluations were performed using the Student t test, the chi‐square test or Fisher's exact test, and unconditional logistic regression analysis.ResultsThe C/C genotype of rs2188380 might be related to BC risk to some extent compared with G/G genotype (OR = 9.241, 95% CI = 1.122‐76.101, P = 0.039). Furthermore, after adjusting the age, the association still existed (OR = 8.788, 95% CI = 1.063‐72.636, P = 0.044). However, no significant association was observed between rs2188380 and the clinicopathological characteristics of BC.ConclusionsOur study primarily indicated that rs2188380 might have a potential association with BC risk to some extent. With a limited sample size and statistical power, further studies based on larger populations are needed to confirm the association.

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Circulating adiponectin levels in various malignancies: an updated meta-analysis of 107 studies

Cited by 57 publications

References 127 publications

Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells

Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells

Impact of intermittent fasting on health and disease processes

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

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