Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus

Hassan, Alan Bapeer; Salih, Sherwan Ferman; Hassan, Israa Issa; Saadi, Farsat Saeed; Abdulah, Deldar Morad; Ahmed, Idris Haji; Taher, Sherzad Majeed; Khaleel, Bland Bayar

doi:10.1016/j.dsx.2018.11.016

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…For example, the pleiotropic adipokine adiponectin was reported to inhibit the expression of inflammatory cytokines and mast cell protease in angiotensin II (AngII)-induced abdominal aortic aneurysm [8]. Angiopoietin-like protein 8 (ANGPTL8) is an adipokine and circulating ANGPTL8 is related to metabolic and inflammatory parameters, and oxidative stress, in patients with type 2 diabetes mellitus [9]. ANGPTL8 was also reported to be a novel regulator of inflammation via selective autophagic degradation of Ikappa B kinase IKKγ [10].…”

Section: Introductionmentioning

confidence: 99%

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

Yang

Jiao

et al. 2020

Cardiovasc Drugs Ther

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Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) is a hormone involved in the regulation of lipid metabolism and inflammation. However, the relationship between ANGPTL8 and TAD remains unknown. Methods This case-control study included 78 TAD patients and 72 controls. The aortic diameter was evaluated by computed tomography and used to assess TAD severity. Circulating ANGPTL8 levels were measured by enzyme-linked immunosorbent assay. Associations of ANGPTL8 with TAD were determined by multivariate logistic regression. Results Serum ANGPTL8 levels were significantly higher in TAD patients compared with controls (562.50 ± 20.84 vs. 419.70 ± 22.65 pg/mL, respectively; P < 0.001). After adjusting for confounding factors, circulating ANGPTL8 levels were an independent risk factor for TAD (odds ratio = 1.587/100 pg ANGPTL8, 95% confidence interval [CI] = 1.121–2.247, P < 0.001) and positively associated with diameter (β = 1.081/100 pg ANGPTL8, 95% CI = 0.075–2.086, P = 0.035) and high-sensitivity C-reactive protein (hs-CRP) (β = 0.845/100 pg ANGPTL8, 95% CI = 0.020–1.480, P = 0.009). The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8, hs-CRP, and D-dimer was 0.927, and the specificity and sensitivity were 98.46% and 79.49%, respectively. ANGPTL8 was significantly increased in TAD tissue compared with controls. In vitro, ANGPTL8 was increased in angiotensin II (AngII)-treated macrophages and vascular smooth muscle cells (VSMCs), while ANGPTL8 siRNA-mediated knockdown decreased inflammatory factors in AngII-treated macrophages and decreased apoptosis in AngII-treated VSMCs. Conclusion ANGPTL8 is associated with TAD occurrence and development, which may involve pro-inflammatory effects on macrophages. ANGPTL8 combined with D-dimer and hs-CRP might be a useful clinical predictor of TAD. Trial Registration ChiCTR-COC-17010792 http://www.chictr.org.cn/showproj.aspx?proj=18288

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Section: Introductionmentioning

confidence: 99%

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

Yang

Jiao

et al. 2020

Cardiovasc Drugs Ther

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“…Betatrophin also showed significant positive correlation with HDL-C in previous studies, [25,28] yet it should be noted that these associations were not found in other reports. Also, Hassan, et al [32] showed that betatrophin was not associated with triglyceride in T2DM. In the present study, we have not found any relationship between betatrophin and triglyceride in anyof the three groups.…”

Section: Discussionmentioning

confidence: 99%

An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes

Altunoğlu¹,

Erdenen²,

Seda³

et al. 2021

Ann Endocrinol Metab

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Progressive loss of mass and function of beta cells are important pathophysiological features of diabetes. There by the best therapy and potential cure for both T1DM and T2DM is to replace orregenerate the insulin-producing pancreatic beta cell. Restoration of the functional beta cell mass is therefore expected to be a key aim of diabetes therapy. In this context, researchers from Harvard Stem Cell Institute (HSBI) recently found a new hormone and named it betatrophin, which could increase the quantity of insulin producing betacells in mice [1]. Before discovery of betatrophin by HSBI, different research teams have named this hormone differently according to its different functions: Including angiotensin amyloid 8(ANGPTL8), lipoprotein lipase

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“…e linear range of the measurement was 0-100 μg/L. e method has high sensitivity and specificity for measuring betatrophin in serum without cross-reaction and interference [28].…”

Section: Betatrophin Measurementsmentioning

confidence: 99%

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

Wenjin²,

Yang³

et al. 2020

BioMed Research International

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The role of IR and metabolic disorders has become a crucial topic of study in the pathogenesis of PCOS. Adipose tissue is an important target organ of insulin, and adipose IR plays an important role in the occurrence and development of PCOS. This study seeks to investigate the role of adipose IR in the development of PCOS and to examine its relationship with circulating betatrophin levels in women with PCOS. A cross-sectional analysis of a cohort of women with PCOS and healthy women was performed in this study. Serum betatrophin concentrations were measured by ELISA. Adipose IR was calculated using the product of fasting insulin and FFA concentrations, and the relationship between adipose IR, circulating betatrophin, and other parameters was analyzed. Adipose IR in women with PCOS was significantly higher than that in controls. We found that women with PCOS who have adipose IR (adipose IR ≥ 55) have a higher BMI and higher blood glucose, insulin, PRL, FFA, TG, HOMA-IR, AUCglucose, AUCinsulin, VAIfemale, and BAI levels than PCOS-afflicted women without adipose IR, while M-values, and SHBG and LH levels were lower. In women with PCOS, serum betatrophin levels were significantly increased compared with controls. Adipose IR negatively correlated with M values and positively with circulating betatrophin levels in the study population. After metformin treatment, circulating betatrophin levels and adipose IR in women with PCOS were significantly decreased compared with pretreatment. Adipose IR is associated with betatrophin levels in women with PCOS. The combination of adipose IR and circulating betatrophin measurements may be significant for screening patients with PCOS.

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Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus

Cited by 11 publications

References 20 publications

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

Increased Circulating Angiopoietin-Like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions

An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

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