Circulating Endothelial Microparticles Correlate Inversely With Endothelial Function in Patients With Ischemic Left Ventricular Dysfunction

Bulut, Daniel; Maier, K.; Bulut-Streich, Nadine; Börgel, Jan; Hanefeld, Christoph; Mügge, Andreas

doi:10.1016/j.cardfail.2007.11.002

Cited by 57 publications

(42 citation statements)

References 28 publications

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“…Thirty-eight (33%) had abnormal MPI (13 with mild MPD (4 B SSS B 8), 13 with moderate MPD (9 B SSS B 13), and 12 with severe MPD (SSS [ 13). Twenty-nine patients with abnormal MPI underwent quantitative coronary angiography (QCA) and 27 (93%) had obstructive CAD defined by[50% luminal stenosis.…”

Section: Resultsmentioning

confidence: 99%

“…11 Abnormal scans were classified as mildly abnormal (4-8), moderately abnormal (9-13), and severely abnormal ( [13). 12 In 29 patients with abnormal MPI, quantitative coronary angiography was performed by standard techniques.…”

Section: Spect Imagingmentioning

confidence: 99%

“…[13][14][15] Nevertheless, there is a considerable heterogeneity in the magnitude of vascular dysfunction in individuals with similar risk factor profile. 16,17 In this regard, vascular dysfunction may be seen as an important ''integrative factor'' of the inherent atherosclerotic risk in an individual, taking into account the cumulative risk of various coronary risk factors, unknown variables, and the genetic susceptibility of vascular endothelium toward coronary risk factors.…”

Section: Vascular Function and Myocardial Perfusionmentioning

confidence: 99%

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Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect

Ahmadi

Usman

Shim

et al. 2009

Journal of Nuclear Cardiology

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Section: Resultsmentioning

confidence: 99%

Section: Spect Imagingmentioning

confidence: 99%

Section: Vascular Function and Myocardial Perfusionmentioning

confidence: 99%

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Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect

Ahmadi

Usman

Shim

et al. 2009

Journal of Nuclear Cardiology

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“…The elevated levels of circulating endothelial microparticles are associated with endothelial dysfunction observed in hypertension, coronary artery diseases, ischaemic stroke, diabetes and other cardiovascular events (19,(25)(26)(27). It has been suggested that these microparticles are implicated in the regulation of coagulation, oxidative stress, inflammation, angiogenesis and apoptosis (18,28).…”

Section: Discussionmentioning

confidence: 99%

Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells

Kam

Razmovski-Naumovski

et al. 2015

J Pharm Pharm Sci

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-PURPOSE:Circulating microparticles have been highlighted as biomarkers of cardiovascular disease state and progression. The aim of this study was to evaluate the effects of curcumin on microparticle release from endothelial cells undergoing TNF-induced cell activation and apoptosis. METHODS: This study evaluated the effects of curcumin on microparticle release, cytotoxicity, apoptosis, cell adhesion molecule expression and monocyte adhesion in EAhy926 human endothelial cells. RESULTS:The results showed that the numbers of microparticles were increased by tumour necrosis factor (TNF) or the combination of TNF and cycloheximide (CHX). Curcumin attenuated microparticle release caused by TNF or TNF plus CHX treatments. The pretreatment by curcumin not only negated the accelerated cell death and apoptosis caused by TNF and CHX, but also diminished TNF-induced cell activation, as assessed by reduced surface expression of intercellular adhesion molecule 1, and adhesion of monocytes to endothelial monolayers. CONCLUSION: Curcumin reduced microparticle release from endothelial cells undergoing cell activation and apoptosis, which supports its protective role in TNF-associated endothelial dysfunction, and highlights its potential use as a nutraceutical agent for vascular inflammatory diseases.

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“…Besides being relevant and specific markers of endothelial integrity, they also behave as biological vectors able to disseminate various pathogenic signals amplifying endothelial dysfunction (13). Convergent data from different studies have demonstrated that the EMP level correlates with the severity of endothelial dysfunction assessed by flow-mediated dilation in patients with endstage renal disease (4) or coronary artery disease (11). To our knowledge, no studies have investigated the influence of physical inactivity on EMP levels in healthy subjects.…”

mentioning

confidence: 99%

Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers

Navasiolava

Dignat-George

Sabatier

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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A sedentary lifestyle has adverse effects on the cardiovascular system, including impaired endothelial functions. Subjecting healthy men to 7 days of dry immersion (DI) presented a unique opportunity to analyze the specific effects of enhanced inactivity on the endothelium. We investigated endothelial properties before, during, and after 7 days of DI involving eight subjects. Microcirculatory functions were assessed with laser Doppler in the skin of the calf. We studied basal blood flow and endotheliumdependent and -independent vasodilation. We also measured plasma levels of microparticles, a sign of cellular dysfunction, and soluble endothelial factors, reflecting the endothelial state. Basal flow and endothelium-dependent vasodilation were reduced by DI (22 Ϯ 4 vs. 15 Ϯ 2 arbitrary units and 29 Ϯ 6% vs. 12 Ϯ 6%, respectively, P Ͻ 0.05), and this was accompanied by an increase in circulating endothelial microparticles (EMPs), which was significant on day 3 (42 Ϯ 8 vs. 65 Ϯ 10 EMPs/l, P Ͻ 0.05), whereas microparticles from other cell origins remained unchanged. Plasma soluble VEGF decreased significantly during DI, whereas VEGF receptor 1 and soluble CD62E were unchanged, indicating that the increase in EMPs was associated with a change in antiapoptotic tone rather than endothelial activation. Our study showed that extreme physical inactivity in humans induced by 7 days of DI causes microvascular impairment with a disturbance of endothelial functions, associated with a selective increase in EMPs. Microcirculatory endothelial dysfunction might contribute to cardiovascular deconditioning as well as to hypodynamia-associated pathologies. In conclusion, the endothelium should be the focus of special care in situations of acute limitation of physical activity. dry immersion; weightlessness; microcirculation; endothelial dysfunction; soluble endothelial markers THE VASCULAR ENDOTHELIUM is a key element in the control of local blood flow (12,46). It is now widely recognized that alterations of endothelial integrity and physiological functions represent pivotal mechanisms in the initiation and development of vascular diseases. A decrease in endothelial vasomotor function (endothelium-dependent vasodilation), which correlates with a risk of cardiovascular events, has been demonstrated in patients with atherosclerosis, hypertension, and peripheral vascular diseases (49). Physical inactivity and a sedentary lifestyle are known to cause cardiovascular deconditioning and increase the risk of cardiovascular disease (5). Endothelial dysfunction seems to be intimately linked to this deconditioning. A chronic decrease in shear stress forces during physical inactivity, especially significant in small vessels of the microcirculatory bed (8), may impair endothelial functions.Experimental physical inactivity of varying duration and intensity in healthy humans can be achieved through confinement (altitude chambers), partial immobilization, bedrest, and "dry" water immersion (33, 34). Dry immersion (DI) induces extreme physical inac...

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Circulating Endothelial Microparticles Correlate Inversely With Endothelial Function in Patients With Ischemic Left Ventricular Dysfunction

Cited by 57 publications

References 28 publications

Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect

Vascular dysfunction measured by fingertip thermal monitoring is associated with the extent of myocardial perfusion defect

Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells

Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers

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