Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women

Kimura, Yasumi; Yasuda, Kazuki; Kurotani, Kayo; Akter, Shamima; Kashino, Ikuko; Hayabuchi, Hitomi; Sato, Masao; Mizoue, Tetsuya

doi:10.1007/s00394-016-1285-y

Cited by 4 publications

(3 citation statements)

References 72 publications

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“…Previously, we found a significant association of serum ferritin with insulin resistance, leptin and visfatin in men, but not in women . In the present study, however, there was no statistically significant sex difference in association between ferritin and type 2 diabetes.…”

Section: Discussioncontrasting

confidence: 91%

“…Previously, we found a significant association of serum ferritin with insulin resistance, leptin and visfatin in men, but not in women. 33,34 In the present study, however, there was no statistically significant sex difference in association between ferritin and type 2 diabetes. Two meta-analyses (one based on prospective studies in Western countries 35 , and another based on various types of studies in Western and Asian countries 17 ) reported no evidence of sex difference in association between ferritin and type 2 diabetes.…”

Section: Discussioncontrasting

confidence: 77%

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Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

Akter

Nanri

Kuwahara

et al. 2017

J of Diabetes Invest

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Aims/IntroductionHigher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals.Materials and MethodsThe participants were 4,754 employees who attended a comprehensive health check‐up in 2008–2009 and donated blood for the study. During 5 years of follow up, diabetes was identified based on plasma glucose, glycated hemoglobin and self‐report. Two controls matched to each case on sex, age and date of check‐up were randomly chosen using density sampling, giving 327 cases and 641 controls with ferritin measurement. Cox proportional hazards regression was used to estimate the hazard ratio while adjusting for a series of potential confounders or mediators.ResultsElevated serum ferritin levels were associated with a significantly increased risk of type 2 diabetes, with the hazard ratio adjusted for known risk factors in the highest vs lowest quartile of 1.42 (95% confidence interval: 1.03–1.96). This association was unchanged after adjustment for C‐reactive protein and adiponectin, but attenuated after adjustment for liver enzyme and insulin resistance (hazard ratio 1.04). The ferritin–diabetes association was confined to non‐obese participants.ConclusionsThese results suggest that elevated iron storage is associated with increased risk of type 2 diabetes in normal weight individuals, and that this association is partly mediated through liver dysfunction and resulting insulin resistance.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussioncontrasting

confidence: 77%

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

Akter

Nanri

Kuwahara

et al. 2017

J of Diabetes Invest

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“…In fact, sFT levels have been associated with the severity of COVID-19 disease progression, correlating higher FT levels with fatal outcomes over time [49]. Other studies have pointed out that circulating FT levels are associated with dysfunctions of the adipose tissue [50,51] and linked with increased risk of cardiovascular disturbances [52]. Moreover, because FT secretion is stimulated by pro-inflammatory cytokines and FTH has pro-inflammatory effects, it has been hypothesized that elevated FT levels in the serum may not only be a consequence of inflammation but also a part of the pathogenic mechanism of the disease, thus contributing to the observed inflammatory burden [53,54].…”

Section: Ferritinmentioning

confidence: 99%

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Fonseca,

Ramos,

Gomes

et al. 2023

Molecules

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The diagnosis of iron disturbances usually includes the evaluation of serum parameters. Serum iron is assumed to be entirely bound to transferrin, and transferrin saturation—the ratio between the serum iron concentration and serum transferrin—usually reflects iron availability. Additionally, serum ferritin is commonly used as a surrogate of tissue iron levels. Low serum ferritin values are interpreted as a sign of iron deficiency, and high values are the main indicator of pathological iron overload. However, in situations of inflammation, serum ferritin levels may be very high, independently of tissue iron levels. This presents a particularly puzzling challenge for the clinician evaluating the overall iron status of the patient in the presence of an inflammatory condition. The increase in serum ferritin during inflammation is one of the enigmas regarding iron metabolism. Neither the origin, the mechanism of release, nor the effects of serum ferritin are known. The use of serum ferritin as a biomarker of disease has been rising, and it has become increasingly diverse, but whether or not it contributes to controlling the disease or host pathology, and how it would do it, are important, open questions. These will be discussed here, where we spotlight circulating ferritin and revise the recent clinical and preclinical data regarding its role in health and disease.

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Evaluation of the relationship between serum ferritin and insulin resistance and visceral adiposity index (VAI) in women with polycystic ovary syndrome

et al. 2020

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Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women

Abstract: Increased iron storage may be associated with higher circulating concentrations of leptin and visfatin in men and with lower concentrations of adiponectin in women.

Cited by 4 publications

References 72 publications

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Evaluation of the relationship between serum ferritin and insulin resistance and visceral adiposity index (VAI) in women with polycystic ovary syndrome

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