Circulating Irisin in Healthy Adults: Changes after Acute Exercise, Correlation with Body Composition, and Energy Expenditure Parameters in Cross-Sectional Study

Abstract

Background and Objectives: Skeletal muscles are considered to be the main source of circulating irisin, both at rest and during physical activity. The aim of this study was to investigate the connection between irisin, body composition, and energy metabolism in humans. Materials and Methods: Serum irisin concentrations before and after acute aerobic exercise on a treadmill in 84 healthy adults were measured and their association with body composition and energy expenditure (EE) (obtained from indirect calorimetry) was determined. Results: The total pre-exercise irisin concentrations in males and females were similar, but higher in females when expressed per body mass kg (p < 0.001). There was an association between pre-exercise irisin per body mass kg, visceral fat rating (rho = −0.52, p = 0.001), and lean tissue % (rho = 0.41, p < 0.05) in males and lean body mass index (LBMI) (rho = −0.59, p < 0.001) in females. The pre-exercise irisin concentration correlated with the resting metabolic rate (RMR) in both sexes (rho = 0.44 in males, rho = 0.36 in females; p < 0.05), but with walking, running, and the EE difference from RMR in running (Δ running EE) in males only (rho = 0.32 to 0.37, p < 0.05). There was no significant change in irisin concentration after exercise in 58% of participants, while it decreased in 23%, and increased in 19%. In male subjects with no change in irisin concentration after exercise, running (p < 0.05) and Δ running EE per body mass kg (p < 0.05) were higher than in those with decreased irisin concentration. Conclusions: These findings indicate that the association of irisin concentration with body composition and EE parameters has sex-dependent differences, and acute exercise can lead to various changes in post-exercise irisin levels.

Systematic Review and Meta-Analysis of Circulating Irisin Levels Following Endurance Training: Results of Continuous and Interval Training

“…Five articles met the inclusion criteria for interval endurance training (Eken & Kafkas, 2022; He et al, 2018; Lagzdina et al, 2020; Nygaard et al, 2015; Tsai et al, 2021), resulting in 7 individual treatment effects because of many group comparisons (Table 2). He et al, 2018 resulted in 2 estimated effects corresponding to a single experimental group that received 2 different interventions.…”

“…He et al, 2018 resulted in 2 estimated effects corresponding to a single experimental group that received 2 different interventions. Eken & Kafkas, 2022 and Lagzdina et al, 2020 each resulted in 2 estimated effects corresponding to 2 experimental groups.…”

“…Interval training sessions were performed via treadmill running, with the exception of Tsai et al, 2021, which used cycle-ergometer training. However, as shown in Table 2, interval training protocols were extremely different, using passive recoveries (Eken & Kafkas, 2022; He et al, 2018; Nygaard et al, 2015) or active recoveries (Lagzdina et al, 2020; Tsai et al, 2021), and short intervals (Eken & Kafkas, 2022; He et al, 2018; Tsai et al, 2021) or longer intervals (Lagzdina et al, 2020; Nygaard et al, 2015).…”

Circulating irisin levels in functional hypothalamic amenorrhea: a new bone damage index? A pilot study

“…In the present study BAT was not measured; hence, this could be an area for future studies. In addition, we did not measure REE in the two groups, although we know it is positively associated with irisin [ 28 ]. The average amenorrhea period considered was quite short (eight months).…”

Myokines in obese adolescents with aerobic exercise

“…В исследовании R. Lagzdina и соавт., включившем 84 здоровых взрослых 20-50 лет (40 мужчин, 44 женщины), после ФН у 58% участников не было выявлено статистически значимого изменения концентрации ирисина после однократной аэробной ФН, в то время как у 23% его уровень уменьшился, а у 19% увеличился [7].…”