Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis

Cai, Xue; Qiu, Shanhu; Li, Ling; Zügel, Martina; Steinacker, Jürgen M.; Schümann, Uwe

doi:10.1016/j.rbmo.2017.10.114

Cited by 24 publications

(27 citation statements)

References 45 publications

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“…Previous studies have shown that circulating ZAG, Irisin and Betatrophin concentrations were significantly reduced or elevated in patients with T2DM or PCOS, respectively, and were associated with IR [10][11][12][20][21][22]. In addition, a recent meta-analysis and other populations had indicated that serum irisin concentration in PCOS women were higher than that in healthy women, this elevaluation could be partly attributed to the BMI in PCOS patients [23][24][25][26]. Therefore, most studies have revealed that circulating Irisin levels indeed has a tendency to increase in PCOS women.…”

Section: Discussionmentioning

confidence: 99%

“…In PCOS patients, circulating ZAG levels were reported to be consistently reduced [10,27,28]. However, the relationship between circulating betatrophin levels and PCOS is controversial and the studies in the literature are inconsistent [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Growing evidence indicates that these cytokines have some roles in the pathogenesis of T2DM and PCOS, and are also involved in IR development.…”

Section: Discussionmentioning

confidence: 99%

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Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

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Aims Irisin, Betatrophin and Zinc-α2-glycoprotein (ZAG) have been shown to be associated with insulin resistance (IR) and polycystic ovary syndrome (PCOS), respectively. The purpose of this study is to explore the potential accuracy of this combination of three cytokines in screening PCOS. Methods 186 individuals were recruited for this study. Circulating Irisin, Betatrophin and ZAG concentrations were measured by enzyme-linked immunosorbent assay. The association between these serum biomarkers and PCOS was assessed by logistic regression analysis. Receiver operating curve (ROC) analysis was performed to evaluate the diagnostic value of these biomarkers for PCOS women. Results In women with PCOS, serum Irisin and Betatrophin levels were markedly elevated compared to those in healthy controls (p<0.01), while ZAG levels were lower (p<0.01). PCOS women with IR (M-value<6.28) had lower circulating ZAG concentrations, and higher circulating Irisin and Betatrophin levels relative to PCOS women without IR (M-value ≥ 6.28). ROC curve analyses showed that the AUC for Irisin, ZAG and Betatrophin for predicting PCOS were 0.77, 0.83 and 0.85, respectively. In a joint ROC curves analysis of these serum markers and other parameters, the results showed that the AUC was 0.93, and the sensitivity and specificity were 82.1 % and 92.3 %, respectively. Conclusions When compared to using single cytokine, the analysis of Irisin, ZAG and Betatrophin elevates the accuracy in diagnosing PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Several Circulating Biomarkers for PCOS Diagnosis

Luo

Zhang

et al. 2019

Exp Clin Endocrinol Diabetes

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“…For studies reporting standard errors, 95% confidence intervals (CIs), or interquartile ranges, the standard deviations were obtained using the methods described in Cochrane Handbook for Systematic Reviews [ 29 ] or reported previously [ 30 ]. For studies including two different exercise training interventions, the control group was split into two groups with smaller sample sizes, aiming to provide reasonably independent comparisons and to overcome the unit-of-analysis error [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis

Qiu

Cai

Yin

et al. 2018

Cardiovasc Diabetol

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Background and aimsExercise training is considered a cornerstone in the management of type 2 diabetes, which is associated with impaired endothelial function. However, the association of exercise training with endothelial function in type 2 diabetes patients has not been fully understood. This meta-analysis aimed to investigate their associations with focus on exercise types.MethodsDatabases were searched up to January 2018 for studies evaluating the influences of exercise training with durations ≥ 8 weeks on endothelial function assessed by flow-mediated dilation (FMD) among type 2 diabetes patients or between type 2 diabetics and non-diabetics. Data were pooled using random-effects models to obtain the weighted mean differences (WMDs) and 95% confidence intervals (CIs).ResultsSixteen databases were included. Exercise training resulted in an overall improvement in FMD by 1.77% (95% CI 0.94–2.59%) in type 2 diabetes patients. Specifically, both aerobic and combined aerobic and resistance exercise increased FMD by 1.21% (95% CI 0.23–2.19%) and 2.49% (95% CI 1.17–3.81%), respectively; but resistance exercise only showed a trend. High-intensity interval aerobic exercise did not significantly improve FMD over moderate-intensity continuous exercise. Notably, the improvement in FMD among type 2 diabetes patients was smaller compared with non-diabetics in response to exercise training (WMD − 0.72%, 95% CI − 1.36 to − 0.08%) or specifically to aerobic exercise (WMD − 0.65%, 95% CI − 1.31 to 0.01%).ConclusionsExercise training, in particular aerobic and combined exercise, improves endothelial function in type 2 diabetes patients, but such an improvement appears to be weakened compared with non-diabetics.Trial registration PROSPERO CRD42018087376Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0711-2) contains supplementary material, which is available to authorized users.

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“…In women with PCOS, the evidence about irisin regulation remains largely conflicting (21,22,23). A study found high serum irisin levels when hyperandrogenism was part of the PCOS phenotype (21), but a recent meta-analysis showed that, with adjustment for BMI, circulating irisin levels are similar in PCOS patients and healthy controls (22). In addition, BAT activity had not been previously assessed in women with PCOS, and we hypothesized that BAT activity and its relation with irisin might be a novel metabolic pathway disrupted in PCOS, with implications for the development of future treatments.…”

Section: Introductionmentioning

confidence: 99%

Brown adipose tissue activity is reduced in women with polycystic ovary syndrome

Oliveira

Mamede

Bizzi

et al. 2019

European Journal of Endocrinology

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Objective To evaluate whether brown adipose tissue (BAT) activity is altered in women with polycystic ovary syndrome (PCOS), and whether BAT activity correlates with plasma levels of irisin, a myokine that can induce BAT formation. Design We performed a cross-sectional study including women with PCOS (n = 45) and a healthy control group (n = 25) matched by age and body mass index (BMI). Methods BAT activity was measured using 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by a validated enzyme immunoassay. Results Total BAT activity was significantly reduced in women with PCOS (maximal standardized uptake value (SUVmax): median 7.4 g/mL, interquartile range 0.9–15.4) compared to controls (median 13.0 g/mL, interquartile range 4.7–18.4, P = 0.047). However, this difference was no longer significant after adjustment for waist circumference, a surrogate marker of central adiposity. In the PCOS group, BAT activity correlated negatively with BMI (Spearman’s r = −0.630, P = 0.000) and waist circumference (r = −0.592, P = 0.000) but not with plasma irisin levels. Conclusions BAT activity was reduced in women with PCOS possibly due to increased central adiposity. In PCOS women, BAT activity did not correlate with plasma irisin levels.

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Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis

Cited by 24 publications

References 45 publications

Several Circulating Biomarkers for PCOS Diagnosis

Several Circulating Biomarkers for PCOS Diagnosis

Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis

Brown adipose tissue activity is reduced in women with polycystic ovary syndrome

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