Circulating lead modifies hexavalent chromium-induced genetic damage in a chromate-exposed population: An epidemiological study

Hu, Guiping; Long, Changmao; Hu, Lihua; Xu, Benjamin; Chen, Tian; Gao, Xiaoyin; Zhang, Yali; Zheng, Pai; Wang, Li; Wang, Tiancheng; Yan, Lailai; Yu, Shanfa; Zhong, Liang; Chen, Wei; Jia, Guang

doi:10.1016/j.scitotenv.2020.141824

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…According to the guidelines of the Organization for Economic Cooperation and Development (OECD) and the Environmental Protection Agency (EPA), a substance or compound that induces more than 4 MN/1000 PCE should be considered a genotoxic agent [29,31]. Our results are consistent with the genotoxic damage reported for Cr(VI) compounds and particularly CrO 3 [26,32], as increases greater than 5 MN were observed at all times evaluated. Administration of resveratrol 4 h before exposure to CrO 3 reduced these frequencies of MN in vivo.…”

Section: Discussionsupporting

confidence: 87%

Protective Effect of Resveratrol against Hexavalent Chromium-Induced Genotoxic Damage in Hsd:ICR Male Mice

et al. 2022

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The aim of this study is to examine the ability of resveratrol to counteract hexavalent chromium [Cr(VI)]-induced genetic damage, as well as the possible pathways associated with this protection. Hsd:ICR male mice are divided into groups of the following five individuals each: (a) control 1, distilled water; (b) control 2, ethanol 30%; (c) resveratrol, 50 mg/kg by gavage; (d) CrO3, 20 mg/kg intraperitoneally; (e) resveratrol + CrO3, resveratrol administered 4 h prior to CrO3. The assessment is performed on peripheral blood. Micronuclei (MN) kinetics are measured from 0 to 72 h, while 8-hydroxydeoxyguanosine (8-OHdG) adduct repair levels, endogenous antioxidant system biomarkers, and apoptosis frequency were quantified after 48 h. Resveratrol reduces the frequency of Cr(VI)-induced MN and shows significant effects on the 8-OHdG adduct levels, suggesting that cell repair could be enhanced by this polyphenol. Concomitant administration of resveratrol and Cr(VI) results in a return of the activities of glutathione peroxidase and catalase to control levels, accompanied by modifications of superoxide dismutase activity and glutathione levels. Thus, antioxidant properties might play an important role in resveratrol-mediated inhibition of Cr(VI)-induced oxidant genotoxicity. The increase in apoptotic cells and the decrease in necrosis further confirmed that resveratrol effectively blocks the actions of Cr(VI).

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Section: Discussionsupporting

confidence: 87%

Protective Effect of Resveratrol against Hexavalent Chromium-Induced Genotoxic Damage in Hsd:ICR Male Mice

et al. 2022

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“…Cr(VI) is a harmful substance commonly found in industrial and environmental settings. ,, Our previous studies have demonstrated that exposure to Cr(VI) can lead to various types of genetic damage, including DNA oxidation, DNA double-strand breaks, chromosomal aberrations, and mitochondrial DNA damage. ,, However, the relationship between immune regulation and genetic damage related to Cr(VI) exposure has not been extensively studied. In this research, the individual levels of genetic damage for participants are listed in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Cr(VI) exposure has been closely associated with the development and progression of malignant tumors such as lung cancer. ,, Our previous studies have demonstrated that exposure to Cr(VI) can lead to various types of genetic damage, including DNA oxidation, DNA double-strand breaks, chromosomal aberrations, and mitochondrial DNA damage. ,, …”

Section: Resultsmentioning

confidence: 99%

“…For instance, in a 10-year cohort study involving 1000 individuals in China, an increase of 1 μg/L in blood Cr levels was associated with an approximately 1.38 μg/g increase in urinary 8-OHdG and a 0.303 ‰ increase in micronucleus frequency (MNF). 5 In another review of the carcinogenic mechanism of chromates, a systematic discussion was conducted on the DNA damage and chromosomal breakage caused by chromates through both direct binding and indirect oxidation. 6 Despite extensive discussions on the relationship between blood Cr and genetic damage, most studies have predominantly explored the toxic effects of Cr(VI) from a cellular perspective.…”

Section: Introductionmentioning

confidence: 99%

“…Genetic damage is the initial stage of compound-induced carcinogenesis, and there is currently substantial evidence suggesting an association between chromate exposure levels and various types of genetic damage. For instance, in a 10-year cohort study involving 1000 individuals in China, an increase of 1 μg/L in blood Cr levels was associated with an approximately 1.38 μg/g increase in urinary 8-OHdG and a 0.303 ‰ increase in micronucleus frequency (MNF) . In another review of the carcinogenic mechanism of chromates, a systematic discussion was conducted on the DNA damage and chromosomal breakage caused by chromates through both direct binding and indirect oxidation .…”

Section: Introductionmentioning

confidence: 99%

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Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods

Su,

Zhang,

Hong

et al. 2024

Environ. Sci. Technol.

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Exposure to hexavalent chromium damages genetic materials like DNA and chromosomes, further elevating cancer risk, yet research rarely focuses on related immunological mechanisms, which play an important role in the occurrence and development of cancer. We investigated the association between blood chromium (Cr) levels and genetic damage biomarkers as well as the immune regulatory mechanism involved, such as costimulatory molecules, in 120 workers exposed to chromates. Higher blood Cr levels were linearly correlated with higher genetic damage, reflected by urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and blood micronucleus frequency (MNF). Exploratory factor analysis revealed that both positive and negative immune regulation patterns were positively associated with blood Cr. Specifically, higher levels of programmed cell death protein 1 (PD-1; mediated proportion: 4.12%), programmed cell death ligand 1 (PD-L1; 5.22%), lymphocyte activation gene 3 (LAG-3; 2.11%), and their constitutive positive immune regulation pattern (5.86%) indirectly positively influenced the relationship between blood Cr and urinary 8-OHdG. NOD-like receptor family pyrin domain containing 3 (NLRP3) positively affected the association between blood Cr levels and inflammatory immunity. This study, using machine learning, investigated immune regulation and its potential role in chromate-induced genetic damage, providing insights into complex relationships and emphasizing the need for further research.

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Hexavalent Chromium Induces Neurotoxicity by Triggering Mitochondrial Dysfunction and ROS-Mediated Signals

Zhang,

Feng,

Cui

et al. 2023

Neurochem Res

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Circulating lead modifies hexavalent chromium-induced genetic damage in a chromate-exposed population: An epidemiological study

Cited by 8 publications

References 41 publications

Protective Effect of Resveratrol against Hexavalent Chromium-Induced Genotoxic Damage in Hsd:ICR Male Mice

Protective Effect of Resveratrol against Hexavalent Chromium-Induced Genotoxic Damage in Hsd:ICR Male Mice

Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine Learning Methods

Hexavalent Chromium Induces Neurotoxicity by Triggering Mitochondrial Dysfunction and ROS-Mediated Signals

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