Circulating Levels of Active, Total and Inactive Renin (Prorenin), Angiotensin I and Angiotensinogen in Carbon Tetrachloride‐treated Rats

Cruz, Cristino; Ibarra-Rubio, María Elena; Pedraza‐Chaverrí, José

doi:10.1111/j.1440-1681.1993.tb00579.x

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…However, there is a controversy about the effect of CC1 4 on serum creatinine level. While some investigators (Cruz et al 1993) found a decrease in serum creatinine in CCl 4 toxicity, parallel to the present study others (Wirth et al 1997; Palaparthy et al 2001; Ozdogan et al 2002; Khan and Al-Zohairy 2011) found no significant changes. In addition current study, reported that calcium, phosphorus, chloride and magnesium values in CC1 4 administrated rats were not statistically different (p > 0.05) from control values (Ogeturk et al 2004).…”

Section: Discussionsupporting

confidence: 85%

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

2013

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The unique characters of camel’s milk make it used extensively in the field of medicine as anti-microbial, anti-diabetic and hepatoprotective agent. The lack of studies demonstrating the protective effect of camel’s milk against hepatotoxic compound was the main reason beyond the conduction of the current experiment which aimed to investigate the protective effects of camel’s milk against carbontetrachloride (CCl4) induced hepatotoxicity. Therefore, 24 rats were fed on standard diet and divided into four groups. Rats of the first group and second groups were injected i/p with paraffin oil and received either tap water (control 1) or camel’s milk (control 2), respectively. Rats of the third and fourth groups were injected i/p with CCl4 and received either tap water or camel’s milk, respectively. At the end of the experiment (5 weeks), blood and liver samples were collected for biochemical and histopathological analysis. The present findings revealed that, CCl4 elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the treatment of rats with camel milk. Histopathologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl4 treated group. The present study concluded that camel milk treatment may play a protective role against CCl4-induced liver damages in rats. These protective effects were in the form of improving of liver enzyme activities, blood biochemical parameters and histological picture of liver of intoxicated rats. In the future, examination of the liver protective effect of camel milk against CCl4 in dose dependant manner could be investigated.

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Section: Discussionsupporting

confidence: 85%

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

2013

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“…As in our experiments, previous experimental studies have shown that CC14 administered at different dosages vŸ different routes increased significantly serum AST (1,6,10,13,18,19,21), ALT (1,6,10,13,18,19,21,27,28), total and conjugated bilirubin (13), ALP (13) and ~-GT (i3) levels, and decreased urea (8,25,32), total protein (13) and albumin (13,21) levels. However, there is a controversy about the effect of CC14 on serum creatinine level.…”

Section: Discussionsupporting

confidence: 66%

Effects of melatonin on carbon tetrachloride-induced changes in rat serum

Ögetürk

Kuş

Kavakli

et al. 2004

J. Physiol. Biochem.

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Carbon tetrachloride (CCl4) is a volatile organic chemical, which causes tissue damage, especially to the liver and kidney. In experimental animals it has been shown to be carcinogenic. This study was designed to evaluate the effects of exogenous melatonin administration on the CCl4-induced changes of some biochemical parameters in rat blood. Twenty-four male Wistar rats were randomly divided into three equal groups: Control, CCl4 and CCl4 plus melatonin (CCl4+MEL). Rats in CCl4 group were injected subcutaneously with CCl4 0.5 ml/kg in olive oil while rats in CCl4+MEL group were injected with CCl4 (0.5 ml/kg) plus melatonin (25 mg/kg in 10% ethanol) every other day for one month. Control rats were treated with olive oil. Serum urea, creatinine, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and conjugated bilirubin, alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total iron, and magnesium levels were determined. Serum AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels were significantly higher in CCl4-treated rats than in the controls, while urea, total protein, and albumin levels were significantly lower. Melatonin treatment did not cause a significantly change in serum urea, total protein, and albumin levels. However, the elevations in AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels induced by CCl4 injections were significantly reduced by melatonin. On the other hand, melatonin administration significantly decreased serum magnesium levels. These results indicate that melatonin could be a protective agent against the CCl4 toxicity in rats, most likely through its antioxidant and free radical scavenger effects.

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“…Also, the reports on the effect of CCl 4 on serum creatinine level tends be contradicting among some investigators. While some investigators [39][40][41][42] found no significant effect of CCl 4 on serum creatinine level, our present study follows the report of other investigators [43] which observed a decrease in the serum creatinine level after CCl 4 intoxication which was significant (p<0.05) compared to the normal control as shown in table 2.…”

Section: Resultssupporting

confidence: 81%