Circulating levels of adiponectin, leptin, resistin and visfatin in non-diabetics patients with hidradenitis suppurativa

What causes hidradenitis suppurativa ?—15 years after

“…129 Resistin and visfatin were proposed to be involved in HS pathogenesis. 130 Moreover, nutritional excess in metabolic syndrome can lead to adipose tissue expansion and adipocyte hypertrophy associated with increased release of inflammatory mediators. In subcutaneous adipose tissue, this can cause cutaneous inflammatory responses but also spill-over of inflammatory mediators into the systemic circulation contributing to progression of the metabolic syndrome.…”

“…As a result, reduced adiponectin and increased resistin serum levels have been identified as surrogate biomarkers for insulin resistance in patients with HS 129 . Resistin and visfatin were proposed to be involved in HS pathogenesis 130 . Moreover, nutritional excess in metabolic syndrome can lead to adipose tissue expansion and adipocyte hypertrophy associated with increased release of inflammatory mediators.…”

Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population

“…In addition to family cases due to mutations in genes encoding essential components of the γ-secretase multiprotein complex (PSEN1, PSENEN, and NCSTN genes) [ 12 , 13 , 14 , 15 ], several other factors including psychological influences, metabolism, smoking habits, bacterial infections, and associations with other diseases (mainly inflammatory disorders) have been related to a higher incidence of HS [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 16 , 29 ]. Recently, our group reported on the role of several adipokines (adiponectin, leptin, resistin, and visfatin) in patients with HS and investigated the possible associations with insulin resistance, HS risk, and disease severity [ 30 ]. The role of the immune system in the etiopathogenesis of HS has yet to be elucidated.…”

Association of retinol binding protein4 (RBP4) and ghrelin plasma levels with insulin resistance and disease severity in non‐diabetic patients with hidradenitis suppurativa

“…Exclusion criteria, clinical evaluation and laboratory studies have been previously described. [3,10] Briefly, patients or controls with a history of CV events, DM and other endocrine diseases, chronic renal or liver failure and/or other inflammatory cutaneous or systemic diseases, or taking drugs (in the previous 6 months) affecting carbohydrate metabolism, were excluded from the study. The severity of HS was assessed by the HS Physician's Global Assessment (HS-PGA); HS was classified as moderate-severe-very severe (PGA ≥ 3) and as minimal-mild HS (PGA < 3).…”

“…[ 1,2 ] Besides, some adipokines that can modulate pro‐inflammatory cytokines levels, have also been recently related to HS pathogenesis. [ 3,4 ]…”