Circulating Levels of Antioxidant Vitamins Correlate with Better Lung Function and Reduced Exposure to Ambient Pollution

Menni, Cristina; Metrustry, Sarah; Mohney, Robert P.; Beevers, Sean; Barratt, Benjamin; Spector, Tim D.; Kelly, Frank J.; Valdes, Ana M.

doi:10.1164/rccm.201411-2059le

Cited by 39 publications

(38 citation statements)

References 14 publications

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“…Glutathione system, thioredoxin system, and vitamins are some of the major non-catalytic components that target the free radicals in non-specific manner [5][6][7]. The catalytic antioxidant machinery mainly involves constitutive and/or induced enzyme systems that target specific free radicals.…”

Section: Introductionmentioning

confidence: 99%

“…These antioxidant supplements may be natural or synthetic in origin. Vitamins that are naturally occurring compounds play a key role in boosting antioxidant capacity, either directly by participating in free radical scavenging or indirectly by promoting the action of other regulators in antioxidant machinery [5,6,12]. Vitamins, in general, have been used for increasing the lifespan in insects [13].…”

Section: Introductionmentioning

confidence: 99%

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Modulation of Oxidative Stress by Abhrak Bhasma in Drosophila Melanogaster

Subedi¹,

Vartak

Kale³

2018

Asian J Pharm Clin Res

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Objective: Management of aging is one of the most actively researched areas in biology. Ayurvedic preparations such as Abhrak Bhasma (AB) have been used for improving longevity and regenerative therapy as well as in treating various ailments. Modes of action of such Ayurvedic preparations are poorly understood at molecular level. Current investigation tests the efficacy of AB in modulating various parameters linked to oxidative stress.Methods: Drosophila melanogaster was used as a model system to test the efficacy of AB in inducing antioxidant machinery. Drosophila flies were fed on diet supplemented with AB at larval and adult stages. Subsequently, various parameters, catalytic as well as non-catalytic, related to antioxidant machinery were analyzed.Results: AB has been found to modulate the activity of superoxide dismutase and catalase enzymes as well as the total reduced glutathione (GSH) content. Larvae and adults feeding on diet supplemented with AB exhibit significantly lower levels of total GSH content (decrease of about 40-70% for larvae, while 31-36% for adults) and without any conclusive effect on GSH:oxidized glutathione ratio, free radical scavenging capacity, and extent of lipid peroxidation. These larvae and adults fed on diet supplemented with AB also exhibited an increase in the level of transcription of cap "n" collar C, heat shock protein 70, and catalase genes (≥1.5 fold, except in few cases). Conclusion:Overall, AB alters various parameters linked to antioxidant machinery in D. melanogaster. The induced components may provide protection to the organism during stressful conditions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modulation of Oxidative Stress by Abhrak Bhasma in Drosophila Melanogaster

Subedi¹,

Vartak

Kale³

2018

Asian J Pharm Clin Res

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“…In the same participants of our study, fatty acid metabolism and amino acid metabolism were found to be enriched after ozone exposure compared to before the exposure 30 . Particulate matter-associated amino acids were also strongly associated with markers of inflammation and lung function 31 .…”

Section: Discussionmentioning

confidence: 96%

Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study

Bind

Rubin

Dhingra³

et al. 2020

Sci Rep

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We used a randomized crossover experiment to estimate the effects of ozone (vs. clean air) exposure on genome-wide DNA methylation of target bronchial epithelial cells, using 17 volunteers, each randomly exposed on two separated occasions to clean air or 0.3-ppm ozone for two hours. Twenty-four hours after exposure, participants underwent bronchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K platform. We performed global and regional tests examining the ozone versus clean air effect on the DNA methylome and calculated Fisher-exact p-values for a series of univariate tests. We found little evidence of an overall effect of ozone on the DNA methylome but some suggestive changes in PLSCR1, HCAR1, and LINC00336 DNA methylation after ozone exposure relative to clean air. We observed some participant-to-participant heterogeneity in ozone responses.

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“…These metabolites, the so-called unknowns, have a big impact on biomedical research as many of them show strong correlations with clinical phenotypes [19][20][21] but their use as functional biomarkers is clearly very limited. The majority of studies ignores the unknowns either by platform design 22 or at the analysis stage 23,24 . Others have tried to solve the problem by employing different computer based methods to try and uncover the unknown true identity.…”

Section: How To Deal With 'Unknown' Moleculesmentioning

confidence: 99%

Mixing omics: combining genetics and metabolomics to study rheumatic diseases

et al. 2017

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Metabolomics is an exciting field in systems biology that provides a direct readout of the biochemical activities taking place within an individual at a particular point in time. Metabolite levels are influenced by many factors, including disease status, environment, medications, diet and, importantly, genetics. Thanks to their dynamic nature, metabolites are useful for diagnosis and prognosis, as well as for predicting and monitoring the efficacy of treatments. At the same time, the strong links between an individual's metabolic and genetic profiles enable the investigation of pathways that underlie changes in metabolite levels. Thus, for the field of metabolomics to yield its full potential, researchers need to take into account the genetic factors underlying the production of metabolites, and the potential role of these metabolites in disease processes. In this Review, the methodological aspects related to metabolomic profiling and any potential links between metabolomics and the genetics of some of the most common rheumatic diseases are described. Links between metabolomics, genetics and emerging fields such as the gut microbiome and proteomics are also discussed.

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Circulating Levels of Antioxidant Vitamins Correlate with Better Lung Function and Reduced Exposure to Ambient Pollution

Cited by 39 publications

References 14 publications

Modulation of Oxidative Stress by Abhrak Bhasma in Drosophila Melanogaster

Modulation of Oxidative Stress by Abhrak Bhasma in Drosophila Melanogaster

Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study

Mixing omics: combining genetics and metabolomics to study rheumatic diseases

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