Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly

Lind, P. Monica; Lind, Lars

doi:10.1016/j.atherosclerosis.2011.05.001

Cited by 177 publications

(113 citation statements)

References 37 publications

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“…Our finding is compatible with another study that analyzed BPA in pregnant women (i.e., mean age 28.8 years) in Taiwan [35]. However, these concentrations are higher than others reported in literature on serum BPA in older adults [17,36]. In the NHANES population, younger individuals tended to have higher BPA exposure [4,13].…”

Section: Discussionsupporting

confidence: 84%

Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults

Lin¹,

Shen²,

Lian³

et al. 2015

Atherosclerosis

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Section: Discussionsupporting

confidence: 84%

Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults

Lin¹,

Shen²,

Lian³

et al. 2015

Atherosclerosis

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“…They suggested that the decreased contractility may lead to coronary insufficiency. There is also a recent study suggesting that exposure to BPA, measured in serum, is associated with atherosclerosis (Lind and Lind 2011) and atherosclerosis development (Olsén et al 2012).…”

Section: Discussionmentioning

confidence: 99%

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Khadrawy²,

2013

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Bisphenol A (BPA) is an endocrine disrupting chemical used on a wide range in industry. Several studies reported that BPA may cause cardiovascular disorders in humans and animals. The present study aims to investigate the effect of BPA on the heart of adult male rats. The rats received a daily oral administration of BPA (25 mg/kg for 6 weeks and 10 mg/kg for 6 and 10 weeks). It was found that BPA at the two studied doses induced a significant increase in malondialdehyde, and a significant decrease in catalase after 6 weeks. Moreover, a significant decrease in reduced glutathione and acetylcholinesterase (AchE) activity was observed after treatment with the two doses of BPA throughout the studied time intervals. The two doses (25 and 10 mg/kg) resulted in a significant decrease in nitric oxide (NO) levels after 6 and 10 weeks, respectively. A significant increase in body weight gain occurred in all animals after BPA treatment. These results suggest that BPA has cardiotoxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, the deficiency of NO and the inhibition of AchE leading to cholinergic activation. The obesity promoting effect of BPA may also participate in the observed cardiovascular disturbances.

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“…The phtalate-related hypertension could be related to the increased plaque echogenicity and intima-media thickening and echogenicity that are more likely to happen in subjects exposed to phtalates (Lind and Lind 2011). In the study performed by Lind et al (2011), MMP was related to the development of carotid plaques in an inverted U-shaped manner while MiBP and MMP levels were associated with the echogenicity of the plaques.…”

mentioning

confidence: 80%

Phtalates: new cardiovascular health disruptors?

Muscogiuri¹,

Colao

2016

Arch Toxicol

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Phtalates are commonly found in several household products such as food packaging, furniture and toys. Humans are exposed to phtalates through different ways such as inhalation, ingestion and dermal contact. Due to the abundance of plastic in our society, the exposure to phtalates is ubiquitous. A growing body of evidence investigated the association of phtalate exposure with cardiovascular risk factors, i.e., obesity, type 2 diabetes and hypertension. Phtalates are thought to contribute to obesity through their binding and activation of PPARγ receptor that in turn results in the upregulation of adipocyte production. Phtalates are also known to interfere with insulin signaling and to increase oxidative stress. All these mechanisms contribute to the onset of insulin resistance. Recent evidences support a role of phtalates in the pathogenesis of atherosclerosis and hypertension. Thus, the aim of this communication was to summarize the current evidences dealing with the association of phtalates and cardiovascular risk factors

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Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly

Cited by 177 publications

References 37 publications

Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults

Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Phtalates: new cardiovascular health disruptors?

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