Circulating levels of cytokines and their site of production in patients with mild to severe chronic heart failure

Petretta, Mario; Condorelli, Gianluigi; Spinelli, Letizia; Scopacasa, Francesco; Caterina, Maurizio De; Leosco, Dario; Vicario, María; Bonaduce, Domenico

doi:10.1067/mhj.2000.110935

Cited by 61 publications

(49 citation statements)

References 23 publications

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“…Thus, although the absence of cytokines is clearly associated with poor outcome of infection, overproduction of cytokines either at steady state or induced by disease may not be advantageous. In humans, circulating inflammatory markers are elevated in medical conditions that increase risk of CAP, such as chronic obstructive pulmonary disease and congestive heart failure (20,21). Although the exact mechanisms that increase risk of CAP in patients with these underlying conditions are poorly understood, high baseline levels of inflammatory markers may be a potential link.…”

mentioning

confidence: 99%

Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia

Yende

Tuomanen

Wunderink

et al. 2005

Am J Respir Crit Care Med

141

119

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Rationale: Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear. Objective: To ascertain role of preinfection inflammatory markers on susceptibility to community-acquired pneumonia (CAP). Methods: Longitudinal analysis over 6.5 yr of a cohort that consisted of 70-to 79-yr-old well-functioning elderly individuals. Measurements: Association between preinfection tumor necrosis factor (TNF), interleukin 6 (IL-6), and C-reactive protein (CRP) levels and CAP requiring hospitalization. Results: Of the 3,075 participants, 161 (5.2%) developed at least one episode of CAP requiring hospitalization over a median duration of 3.3 yr. The highest tertiles of TNF (Ͼ 3.7 pg/ml) and IL-6 (Ͼ 2.4 pg/ml) were associated with increased risk of CAP, and the adjusted odds ratios were 1.6 (95% confidence interval [CI], 1.02-2.7) and 1.7 (95% CI, 1.1-2.8), respectively. The adjusted risk of CAP with at least one of these markers in the highest tertile was 1.6 (95% CI, 1.1-2.3). TNF and IL-6 levels in the highest tertile had a synergistic effect (p ϭ 0.01 for interaction), and risk of CAP for both markers in the highest tertile was 2.8 (95% CI, 1.8-4.3). An FEV 1 of 50% or less of predicted was associated with the highest risk of CAP (adjusted odds ratio, 3.6; 95% CI, 2.3-5.6). Furthermore, TNF and IL-6 levels modified risk of CAP in participants with coexisting medical conditions and history of smoking. Conclusion: In the well-functioning elderly subjects, preinfection systemic levels of TNF and IL-6 were associated with higher risk of CAP requiring hospitalization in smokers and those with coexisting medical conditions.

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mentioning

confidence: 99%

Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia

Yende

Tuomanen

Wunderink

et al. 2005

Am J Respir Crit Care Med

141

119

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“…3 Although these effects are deemed negative, no correlation was found between TNF-␣, its soluble receptors, and left ventricular end diastolic volume and ejection fraction, or pulmonary wedge pressure. 4 In contradiction to the paradigm of TNF-␣ being harmful, other studies reveal that TNF-␣ has a protective negative inotropic action on the failing heart and stimulates the production of heat shock proteins, which enable cells to survive transient stresses, such as ischemia. 5 Injection of TNF-␣ improves survival of TNF-␣ Ϫ/Ϫ knockout mice infected with encephalomyocarditis virus in a dose-dependent manner by increasing viral clearance.…”

Section: Discussionmentioning

confidence: 99%

Sudden Death in a Patient Without Heart Failure After a Single Infusion of 200 mg Infliximab: Does TNF-α Have Protective Effects on the Failing Heart, or Does Infliximab Have Direct Harmful Cardiovascular Effects?

Clari¹,

Salani²,

Safwan³

et al. 2002

Circulation

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“…Elevated circulating levels of IL6 have been demonstrated in HF patients, and their serum level expression in cardiac tissue has been correlated with severity of left ventricular function and progression of HF 27 . IL6 has a negative inotropic effect as a consequence of an IL6-induced myocardium hypocontractile state, which explains why patients with uncompensated HF have higher IL6 levels than patients in the recovery phase 28 , reflecting the hemodynamic deterioration in HF patients 29 . In the present paper, even though IL6 levels were elevated in 48% of patients, they were not associated with seropositivity or with higher degrees of HF.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Bravo-Tobar

Parra²,

Pérez

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Heart failure (HF) represents the final stage of chronic chagasic cardiomyopathy (CChC). The diagnosis of CChC is based on the demonstration of anti-Trypanosoma cruzi antibodies (aTcAg) and clinical and epidemiological data. In Venezuela, there are no data about the prevalence of chagasic HF. The aim of this study was to determine the epidemiological, clinical, and inflammatory risk factors associated with seronegative or seropositive HF patients. Methods: We performed a cross-sectional study in the Venezuelan central-west states among a healthy rural population and in patients admitted to the emergency room with uncompensated HF. Results: The seroprevalence rates of Trypanosoma cruzi antibodies were 11.2% and 40.1% in the healthy population and in HF patients, respectively. Seropositivity in healthy individuals was associated with age, knowledge on triatomine vectors, and having seen wild reservoirs in the house; in HF patients, with contact with the vector and previous clinical diagnosis of Chagas' disease; and in both groups taken together, with age, knowledge on triatomines, and HF. Seropositive patients had prolonged QRS, decreased ejection fraction, and high serum magnesium, all significant as compared with HF seronegative cases. Left atrium enlargement and ventricular hypertrophy were most frequently observed in HF seronegative patients. CRP, IL6, ILβ1, IL2, and FNTα were elevated in 94.5%, 48%, 17.8%, 13.7%, and 6.9% of HF patients, respectively, but only IL2 levels were associated with chagasic HF. Conclusions: There is a high prevalence of aTcAg in HF patients from the central-west region of Venezuela, and their epidemiological, clinical, and inflammatory features are discreetly different as compared with those of seronegative cases.

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Circulating levels of cytokines and their site of production in patients with mild to severe chronic heart failure

Cited by 61 publications

References 23 publications

Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia

Preinfection Systemic Inflammatory Markers and Risk of Hospitalization Due to Pneumonia

Sudden Death in a Patient Without Heart Failure After a Single Infusion of 200 mg Infliximab: Does TNF-α Have Protective Effects on the Failing Heart, or Does Infliximab Have Direct Harmful Cardiovascular Effects?

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

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