Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year–A cross-sectional and prospective analysis

Hoffmann, Carlotta; Schwarz, Peter E. H.; Mantzoros, Christos S.; Birkenfeld, Andreas L.; Wolfrum, Christian; Solimena, Michele; Bornstein, Stefan R.; Perakakis, Nikolaos

doi:10.1016/j.diabres.2023.110636

Diabetes Research and Clinical Practice

2023

DOI: 10.1016/j.diabres.2023.110636

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Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year–A cross-sectional and prospective analysis

Carlotta Hoffmann

Peter E. H. Schwarz

Christos S. Mantzoros

et al.

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2024

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Cited by 4 publications

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Hormone imbalances detected in study participants with pre-diabetes in a Durban-based clinical setting, South Africa

Sosibo,

Mzimela,

Ngubane

et al. 2024

Int J Diabetes Dev Ctries

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Background Type II diabetes mellitus onset is linked with hormonal imbalances. However, the knowledge about hormonal alterations in pre-diabetes is limited. Objective The study aimed to examine type II diabetes mellitus-associated hormone levels during the pre-diabetes phase in participants aged 25–45 in a Durban-based clinical setting in South Africa. Methods Stored plasma samples from a retrospective study collected 364 samples that were divided into pre-diabetes and non-pre-diabetes groups. From the 364, 38 samples from the group of persons without pre-diabetes and 38 from persons with glycated haemoglobin determined pre-diabetes were blindly selected. The hormone concentrations (C-peptide, cortisol, adipokines, thyroids, incretins, and sex steroids) of the study participants were measured using the BIO-RAD Bio-Plex MAGPIX instrument. Results Hormone imbalances in several hormones were detected in study participants with pre-diabetes. Most of the hormone dysregulation associated with T2DM begins in pre-diabetes but at a moderate level. Conclusion The findings reveal new possible hormone therapy targets for pre-diabetes and contribute to the growing support for targeting pre-diabetes as a preventative measure for T2DM prevention.

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Hormone imbalances detected in study participants with pre-diabetes in a Durban-based clinical setting, South Africa

Sosibo,

Mzimela,

Ngubane

et al. 2024

Int J Diabetes Dev Ctries

View full text Add to dashboard Cite

show abstract

The association of fasting and postprandial GIP and glucagon levels with glycemic variability evaluated by flash glucose monitoring system in type 1 diabetes

Babayeva,

Coskun,

Yalcin

et al. 2024

Int J Diabetes Dev Ctries

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The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation

Stefanakis,

Kokkorakis,

Mantzoros

2024

Metabolism

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Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year–A cross-sectional and prospective analysis

Cited by 4 publications

References 29 publications

Hormone imbalances detected in study participants with pre-diabetes in a Durban-based clinical setting, South Africa

Hormone imbalances detected in study participants with pre-diabetes in a Durban-based clinical setting, South Africa

The association of fasting and postprandial GIP and glucagon levels with glycemic variability evaluated by flash glucose monitoring system in type 1 diabetes

The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation

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