Circulating levels of ghrelin, galanin, and orexin-A orexigenic neuropeptides in obstructive sleep apnea syndrome

Öztürk, Önder; Cebeci, Defne; Şahin, Uğur; Tülüceoğlu, Eda Evgen; Calapoğlu, Nilüfer Şahin; Gonca, Taner; Calapoğlu, Mustafa

doi:10.1007/s11325-021-02514-w

Cited by 9 publications

(16 citation statements)

References 36 publications

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“…Three studies [ 42 , 59 , 63 ] showed a reduced significant level of OXA in aOSA compared to controls. In contrast, three articles [ 43 , 57 , 58 ] reported an elevated significant level of OXA in aOSA compared to controls. Low levels of OXA may prevent arousal during sleep or may be the result of sleepiness from repeated arousals caused by a mechanism independent of OXA [ 42 ], and also obesity in individuals with OSA may be induced by decreased orexin neuron activity or levels of OXA [ 82 ].…”

Section: Discussionmentioning

confidence: 94%

“…Table 1 reports the data for the variables of fourteen studies from the thirteen articles [ 40 , 41 , 42 , 43 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ] included in the meta-analysis. With regard to the studies reporting OM-1 levels, four were reported among Caucasians and two among Asians, and for the studies reporting OXA levels, three were among Caucasians and five among Asians.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Mohammadi

Sadeghi

Tajmiri

et al. 2023

Life

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Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells. Herein, a systematic review and meta-analysis checked the changes in serum/plasma levels of omentin-1 (OM-1: an adipokine) and orexin-A (OXA: a neuropeptide) in adults (age > 18 years old) with OSA (aOSA) compared to controls. Materials and methods: Four databases (Cochrane Library, PubMed, Web of Science, and Scopus) were systematically searched until 14 November 2022, without any restrictions. The Joanna Briggs Institute (JBI) critical appraisal checklist adapted for case–control studies was used to assess the quality of the papers. The effect sizes were extracted using the Review Manager 5.3 software for the blood levels of OM-1 and OXA in aOSA compared with controls. Results: Thirteen articles, with six studies for OM-1 levels and eight for OXA levels, were included. The pooled standardized mean differences were −0.85 (95% confidence interval (CI): −2.19, 0.48; p = 0.21; I2 = 98%) and −0.20 (95%CI: −1.16, 0.76; p = 0.68; I2 = 96%) for OM-1 and OXA levels, respectively. Among the studies reporting OM-1, five were high and one was moderate quality. Among the studies reporting OXA, six were moderate, one was high, and one was low quality. Based on the trial sequential analysis, more participants are needed to confirm the pooled results of the analyses of blood levels of OM-1 and OXA. In addition, the radial plot showed outliers as significant factors for high heterogeneity. Conclusions: The main findings indicated a lack of association between the blood levels of OM-1 and OXA and OSA risk. Therefore, OM-1 and OXA did not appear to be suitable biomarkers for the diagnosis and development of OSA.

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Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Mohammadi

Sadeghi

Tajmiri

et al. 2023

Life

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“…Tables 3 and 4 show JBI critical appraisal checklist for case-control studies and NIH quality assessment tool for before-after studies, respectively. The questions of the JBI critical appraisal checklist and the NIH quality assessment tool have been reported in the The left column shows the first author's names and publication years of studies for twelve articles [28,29,40,41,[54][55][56][57][58][59][60][61] included in the analysis. One article [59] included two independent studies marked with i and ii.…”

Section: Quality Scoresmentioning

confidence: 99%

“…Names of studies are shown on the left, std. mean differences (green boxes) and confidence intervals (horizontal lines) on the right.The left column shows the first author's names and publication years of studies for twelve articles[28,29,40,41,[54][55][56][57][58][59][60][61] included in the analysis. One article[59] included two independent studies marked with i and ii.…”

mentioning

confidence: 99%

“…(B) Before and after continuous positive airways pressure therapy in adults with OSA.Each number shows one study that the studies with related numbers are represented in right side. Each number in up and right shows one study that (A) shows thirteen studies from twelve articles[28,29,40,41,[54][55][56][57][58][59][60][61] and (B) ahows nine studies from six articles[39][40][41][42]59,62]. The articles with two independent studies[39,40,59] have marked with i and ii or iii and iv.…”

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confidence: 99%

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Effect of Continuous Positive Airway Pressure on Changes of Plasma/Serum Ghrelin and Evaluation of These Changes between Adults with Obstructive Sleep Apnea and Controls: A Meta-Analysis

Golshah

Imani

Sadeghi

et al. 2023

Life

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Background and objective: Obstructive sleep apnea (OSA) can be related to high ghrelin hormone levels that may encourage additional energy intake. Herein, a new systematic review and meta-analysis were performed to check the changes in serum/plasma levels of ghrelin in adults with OSA compared to controls, as well as before compared after continuous positive airway pressure (CPAP) therapy in adults with OSA. Materials and methods: Four main databases were systematically and comprehensively searched until 17 October 2022, without any restrictions. For assessing the quality, we used the Joanna Briggs Institute (JBI) critical appraisal checklist adapted for case–control studies and the National Institutes of Health (NIH) quality assessment tool for before–after studies. The effect sizes were extracted by the Review Manager 5.3 software for the blood of ghrelin in adults with OSA compared with controls, as well as before and after CPAP therapy. Results: Fifteen articles involving thirteen studies for case–control studies and nine articles for before–after studies were included. The pooled standardized mean differences were 0.30 (95% confidence interval (CI): −0.02, 0.61; p = 0.07; I2 = 80%) and 0.10 (95% CI: −0.08, 0.27; p = 0.27; I2 = 42%) for case–control and before–after studies, respectively. For thirteen case–control studies, nine had moderate and four high qualities, whereas for nine before–after studies, five had good and four fair qualities. Based on the trial sequential analysis, more studies are needed to confirm the pooled results of the analyses of blood ghrelin levels in case–control and before–after studies. In addition, the radial plot showed outliers for the analysis of case–control studies that they were significant factors for high heterogeneity. Conclusions: The findings of the present meta-analysis recommended that the blood levels of ghrelin had no significant difference in the adults with OSA compared with the controls, nor did they have significant difference in adults with OSA before compared with after CPAP therapy. The present findings need to be confirmed in additional studies with more cases and higher qualities.

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Associations between daytime and nighttime plasma orexin A levels and cognitive function in patients with obstructive sleep apnea

Zhu

Zeng

Xiong

et al. 2022

Sleep Biol. Rhythms

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Circulating levels of ghrelin, galanin, and orexin-A orexigenic neuropeptides in obstructive sleep apnea syndrome

Cited by 9 publications

References 36 publications

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Effect of Continuous Positive Airway Pressure on Changes of Plasma/Serum Ghrelin and Evaluation of These Changes between Adults with Obstructive Sleep Apnea and Controls: A Meta-Analysis

Associations between daytime and nighttime plasma orexin A levels and cognitive function in patients with obstructive sleep apnea

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