Circulating levels of urocortin neuropeptides are impaired in children with overweight

Abstract

The rise in the prevalence of childhood obesity is an increasing public health problem worldwide, particularly in societies that have witnessed a profound change in lifestyle associated with higher food intake and decreased physical activity during the past few decades (1). The number of children aged 5 to 19 years old living with obesity in 2019 is estimated to be 158 million worldwide and is expected to reach approximately 254 million by 2030 (2). These changes are accompanied by a rise in obesity-related metabolic disorders, including insulin resistance, dyslipidemia, and hormonal dysregulation (3). More alarmingly, nearly 80% of children and

Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?

“…This is particularly important due to the fact that disorders of the peptide and/or neuropeptide profile at the stage of fetal or infant life cause such disorders in older children, which are very often associated with metabolic disorders caused by increased body weight or obesity [ 33 ].…”

“…The available data focus primarily on gestational age, preclampsia, type 2 diabetes, and metabolic syndrome as potential factors affecting this parameter [29][30][31][32]. This is particularly important due to the fact that disorders of the peptide and/or neuropeptide profile at the stage of fetal or infant life cause such disorders in older children, which are very often associated with metabolic disorders caused by increased body weight or obesity [33].…”

Corticotropin‐releasing hormone and obesity: From fetal life to adulthood

“…Kavalakatt et al investigated the expression and plasma levels of CRH and UCN‐1, UCN‐2, and UCN‐3 in children with normal weight (NW), OW, and OB and their association with anthropometric and biochemical markers 103 . This study reported an association of UCN‐1, UCN‐2, and UCN‐3 and OW, although this association was less significant in OB children.…”

“…The impact of these dysregulations on morbidity, including cardiovascular disease, and reduced lifespan in future generations emphasizes the importance of understanding the pathophysiological mechanisms that occur in children with OB 102 . It is known that neuropeptides have an important role in the regulation of energy balance, but its status in children with overweight (OW) or OB is not completely understood 103 …”

“…102 It is known that neuropeptides have an important role in the regulation of energy balance, but its status in children with overweight (OW) or OB is not completely understood. 103 Kavalakatt et al investigated the expression and plasma levels of CRH and UCN-1, UCN-2, and UCN-3 in children with normal weight (NW), OW, and OB and their association with anthropometric and biochemical markers. 103 This study reported an association of UCN-1, UCN-2, and UCN-3 and OW, although this association was less significant in OB children.…”