2020
DOI: 10.1002/ijc.33351
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Circulating liver function markers and colorectal cancer risk: A prospective cohort study in the UK Biobank

Abstract: Evidence links the liver to development of colorectal cancer (CRC). However, it remains unknown how liver function may influence CRC risk in the general population. We conducted a prospective cohort study in the UK Biobank of 375 693 participants who provided blood samples in 2006 to 2010. Circulating levels of liver function markers (alanine transaminase [ALT], aspartate transaminase [AST], total bilirubin [TBIL], gamma glutamyltransferase [GGT], alkaline phosphatase [ALP], total protein [TP] and albumin [ALB… Show more

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Cited by 46 publications
(37 citation statements)
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References 51 publications
(115 reference statements)
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“…We found evidence that increased IGF1 levels are associated with CRC. These results are in accordance with the results obtained by previous studies [ 16 , 17 ] and might suggest that elevated serum IGF1 levels may have a role in CRC development. The current clinical practice for colorectal cancer surveillance in individuals with acromegaly and increased blood IGF1 levels is augmented by our findings.…”
Section: Discussionsupporting
confidence: 93%
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“…We found evidence that increased IGF1 levels are associated with CRC. These results are in accordance with the results obtained by previous studies [ 16 , 17 ] and might suggest that elevated serum IGF1 levels may have a role in CRC development. The current clinical practice for colorectal cancer surveillance in individuals with acromegaly and increased blood IGF1 levels is augmented by our findings.…”
Section: Discussionsupporting
confidence: 93%
“…IGF1 receptors are expressed by colonocytes and are typically overexpressed in cancer cells. In colorectal tissue, IGF1 has been demonstrated to increase cellular proliferation, and blocking the IGF1-receptor with a monoclonal antibody decreases cell proliferation [ 16 ].…”
Section: Discussionmentioning
confidence: 99%
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