Circulating Lp-PLA2 activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy

Paik, Jean Kyung; Kim, Minkyung; Yen, Y.-Y.; Ahn, Hyeon Yeong; Lee, Sang Hyun; Lee, Jong Ho

doi:10.1007/s11357-015-9770-4

Cited by 16 publications

(9 citation statements)

References 42 publications

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“…The circulating levels of inflammatory cytokines increase with age, leading to a subclinical inflammatory state. 8,24 Similar to previous studies, the present study showed an age-related decrease in IGF-1 level and age-related increases in IL-6 and TNF-a levels. Additionally, changes in IGF-1 expression were negatively correlated with changes in the IL-6 and TNF-a levels.…”

Section: Discussionsupporting

confidence: 91%

“…Low IGF‐1 levels are associated with high IL‐6 and TNF‐α levels in community‐dwelling elderly subjects . The circulating levels of inflammatory cytokines increase with age, leading to a subclinical inflammatory state . Similar to previous studies, the present study showed an age‐related decrease in IGF‐1 level and age‐related increases in IL‐6 and TNF‐α levels.…”

Section: Discussionsupporting

confidence: 88%

“…There is an age-related decline in the level of insulin-like growth factor (IGF)-1, a sensitive marker reflecting changes in nutritional status, especially in the elderly. Conversely, there is an agerelated increase in pro-inflammatory cytokine levels (8) . Therefore, it is important to establish whether diet supplementation is an effective strategy for improving the outcomes of elderly people at risk of a chronic subclinical inflammatory state resulting from undernutrition.…”

Section: Introductionmentioning

confidence: 99%

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Supplementation with nutrients modulating insulin‐like growth factor‐1 negatively correlated with changes in the levels of pro‐inflammatory cytokines in community‐dwelling elderly people at risk of undernutrition

Kim

Lee

Song

et al. 2016

J Human Nutrition Diet

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Supplementation with nutrients modulating insulin‐like growth factor‐1 negatively correlated with changes in the levels of pro‐inflammatory cytokines in community‐dwelling elderly people at risk of undernutrition

Kim

Lee

Song

et al. 2016

J Human Nutrition Diet

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“…Generally, Lp‐PLA2, involved in the metabolism of LDLc, is positively associated with BMI . It is recognized that BMI is the predictor of high Lp‐PLA2 levels and CVD risk in the population . Moreover, as mentioned above, AAP, especially, olanzapine and clozapine pose a higher risk of weight gain and type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Atypical Antipsychotic Administration in Schizophrenic Patients Leads to Elevated Lipoprotein‐Associated Phospholipase A2 Levels and Increased Cardiovascular Risk: A Retrospective Cohort Study

Shen

Wang

et al. 2018

Basic Clin Pharma Tox

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The prevalence of cardiovascular disease (CVD) is higher in patients with schizophrenia than in the general population. We aimed to investigate whether atypical antipsychotics (AAP) increase the levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), thereby increasing the risk of CVD. The data were from inpatients aged 18-60 years with a diagnosis of schizophrenia according to ICD-10 at the Affiliated Brain Hospital of Nanjing Medical University who underwent physical examination between 1 October 2014 and 30 September 2016. A retrospective cohort study was used to analyse the correlation between AAP, Lp-PLA2 levels and the CVD risk (it was determined that Lp-PLA2 values >200 ng/mL were defined as high CVD risk) in patients treated with monotherapy, olanzapine, clozapine or quetiapine. Data were collected for 452 patients with eligible schizophrenia: 163 treated with clozapine, 186 treated with olanzapine, 47 treated with quetiapine and 56 receiving no medication. Compared with the no-medication patients, AAP administration in patients with olanzapine, clozapine or quetiapine had higher serum Lp-PLA2 levels when age, sex, BMI and fasting glucose level were matched. AAP were significantly associated with serum Lp-PLA2 level by Spearman's correlation coefficients. The results of logistic regression analysis showed that AAP administration was an independent factor of CVD risk when adjusted by potential confounding factors. This study is the first to confirm that AAP administration, especially clozapine and olanzapine, could increase Lp-PLA2 levels and CVD risk, independent of drug-induced weight gain in schizophrenia. The extent and the factors of increasing Lp-PLA2 level and CVD risk in olanzapine, clozapine and quetiapine are discrepant. The possible effects of AAP on Lp-PLA2 in schizophrenia patients are involved in pro-inflammatory cytokines and hormones.

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“…So reducing centralized fat mass and maintaining a favorable lipid profile, antioxidant status and iron status may be important in protecting postmenopausal women from atherosclerotic disease [3].…”

Section: Introductionmentioning

confidence: 99%

Possible Role of Nrf2 in Oxidative and Inflammatory Processes During Menopause

Mendoza¹,

Zamarripa²,

Hernández³

et al. 2016

A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2

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The increase in life expectancy leads to the possibility of development chronic diseases, from special physiological conditions as occurs in the menopause, which is defined as the permanent cessation of ovulation, marked by the end of menstruation. It has been related to decreased ovarian function that occurs around an age of 45 years. This event involves the reduction in estrogen production and may contribute to the development of chronic-degenerative diseases. Many diseases developed during menopause have been associated with oxidative stress, such as osteoporosis, hot flushes, cognitive impairment, insulin resistance, dry skin, obesity, and cardiovascular events. The knowledge about the participation of Nrf2 in diseases that occur during menopause is very limited. Here, only diseases such as osteoporosis, cardiovascular diseases and dry skin, which are present during menopause and its later stages have been described. The Nrf2 pathway involves the participation of PI3K/Akt, MAPK, and eNOS, which act as mediators for cytoprotection and antioxidation. Compounds such as equol, fitoestrogens, alkyl cathecols, or curcumin could be offered as options to antioxidant treatment, added the fact that they are present in fruits and vegetables which are rich in vitamins, minerals and calcium, thus including all the required nutrients for an adequate nutrition.

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Circulating Lp-PLA2 activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy

Cited by 16 publications

References 42 publications

Supplementation with nutrients modulating insulin‐like growth factor‐1 negatively correlated with changes in the levels of pro‐inflammatory cytokines in community‐dwelling elderly people at risk of undernutrition

Supplementation with nutrients modulating insulin‐like growth factor‐1 negatively correlated with changes in the levels of pro‐inflammatory cytokines in community‐dwelling elderly people at risk of undernutrition

Atypical Antipsychotic Administration in Schizophrenic Patients Leads to Elevated Lipoprotein‐Associated Phospholipase A2 Levels and Increased Cardiovascular Risk: A Retrospective Cohort Study

Possible Role of Nrf2 in Oxidative and Inflammatory Processes During Menopause

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