Circulating microparticles in migraine with aura: Cause or consequence, a link to stroke

Tietjen, Gretchen E.

doi:10.1177/0333102414529670

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…The role of endothelium in migraine pathogenesis and migraine-associated stroke has been raised during the past decades [55]. Endothelium participates in homeostasis influencing a vascular reactivity, but also thrombolysis, thrombosis, proliferation, and apoptosis [56].…”

Section: The Underlying Mechanisms Of Coincidence Migraine and Strokementioning

confidence: 99%

“…Among endothelial biomarkers of injured endothelium are vascular endothelial growth factor, t- PA, von Willebrand factor, C-reactive protein, reduced nitrate levels, all of which were found in migraineurs, some only in migraineurs with aura [58, 59]. Inflammatory cytokines released in the aura phase activate the endothelium leading to procoagulatory and prothrombotic state [55]. However, research of cerebrovascular reactivity in migraineurs has demonstrated conflicting data (decreased or increased cerebral vascular reactivity) in regard to the causal relationship of endothelium dysfunction in stroke pathogenesis [60–62].…”

Section: The Underlying Mechanisms Of Coincidence Migraine and Strokementioning

confidence: 99%

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Migraine and Stroke: What’s the Link? What to Do?

Gryglas

Śmigiel

2017

Curr Neurol Neurosci Rep

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Migraine and stroke are common, disabling neurologic disorders, with a high socioeconomic burden. A link between them has been proposed years ago, and various theories have been proposed to explain this bidirectional relation. However, the precise causes remain unclear. We briefly summarize existing hypotheses of this correlation seeking for recommendations for stroke prevention in migraineurs, if any exist. Among the strongest suggested theories of migraine–stroke association are cortical spreading depression, endovascular dysfunction, vasoconstriction, neurogenic inflammation, hypercoagulability, increased prevalence of vascular risk factors, shared genetic defects, cervical artery dissection, and patent foramen ovale. There is no evidence that any preventive therapy in migraineurs should be used to decrease stroke risk, even in most predisposed subset of patients. However, a woman with migraine with aura should be encouraged to cease smoking and avoid taking oral contraceptives with high estrogen doses. We need further investigation to better understand the complexity of migraine–stroke association and to make firm recommendations for the future.

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Section: The Underlying Mechanisms Of Coincidence Migraine and Strokementioning

confidence: 99%

Section: The Underlying Mechanisms Of Coincidence Migraine and Strokementioning

confidence: 99%

Migraine and Stroke: What’s the Link? What to Do?

Gryglas

Śmigiel

2017

Curr Neurol Neurosci Rep

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“…The underlying mechanisms of migraine and stroke remain inconclusive, but some hypotheses have been proposed by researchers. The pathogenic mechanisms explaining how migraine in uences ischemic stroke risk include cortical spreading depression (CSD) theory 36,37,38 , endovascular dysfunction theory 39,40,41 , the theory of cerebrovascular hypoperfusion induced by vasospasm 42 , hypercoagulability theory 43,44 , neurogenic in ammation theory 45 , companion theory of increased prevalence of vascular risk factors 46,47,48 , and theory of shared genetic defects 49,50 , etc. The pathogenic mechanism illustrating the relationship between migraine and elevated hemorrhagic stroke risk was limited.…”

Section: Discussionmentioning

confidence: 99%

Migraine and the risk of stroke: a systematic review and meta-analysis

Shu

Wan

Zhang

et al. 2021

Preprint

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Background and Purpose The relationship between migraine status and stroke risk was not determined. This study aims to summarize the existing evidence from prospective cohort studies. Methods We searched Pubmed, Embase, and the Cochrane Library from inception to Dec 2020, and all retrieved articles were screened by two independent reviewers. We extracted and assessed data by a structured and standardized data extraction form. The effect values were calculated using a random-effects model. This review was prospectively registered with the PROSPERO database (CRD42020197137). Results Out of 10,705 records, 19 cohort studies including a combined total of 3,523,235 participants were finally included in the meta-analysis. At a mean of 9.31 years (range 1.4–20 years) follow-up, migraine was associated with an elevated risk of total stroke (pooled RR 1.69, 95%CI 1.36 to 2.11, P < 0.001, I2 = 86%), ischemic stroke (pooled RR 1.46, 95%CI 1.14 to 1.87, P < 0.001, I2 = 95.8%), and hemorrhagic stroke (pooled RR 1.37, 95%CI 1.04 to 1.81, P < 0.001, I2 = 85.9%). The prespecified subgroup analysis found that this kind of relationship existed in migraine with aura (ischemic stroke: pooled RR 1.75, 95%CI 1.35 to 2.29, P < 0.001, I2 = 81.7%; hemorrhagic stroke: pooled RR 1.63, 95%CI 1.26 to 2.10, P = 0.266, I2 = 23.2%), but not migraine without aura. Conclusions Our study implies that migraine, particularly migraine with aura, was associated with an increased risk for both ischemic and hemorrhagic stroke.

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“…The original Hungarian CHQQ scale showed adequate reliability, criterion and convergent validity in migraineurs and tension type headache patients (Manhalter et al 2012), with migraineurs having significantly lower scores (worse QOL) in 16 of the 23 items, all dimensions and total score, as expected. The preliminary results of CHQQ’s validation in 60 patients suffering from cluster headache were also encouraging, with excellent reliability and adequate criterion and convergent validity (Ertsey et al 2015a). The CHQQ was recently found to be responsive to the effect of treatment in a pilot study of patients suffering from medication overuse headache (Gyüre et al 2014).…”

Section: Introductionmentioning

confidence: 98%

The psychometric properties of the Comprehensive Headache-related Quality of life Questionnaire (CHQQ) translated to Serbian

et al. 2016

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BackgroundThe Comprehensive Headache-related Quality of life Questionnaire (CHQQ), is a recently developed and validated instrument, intended for measuring quality of life of patients with all headache types. Currently no validated headache-specific quality of life questionnaires are available in Serbian. The aim of this study was to translate the CHQQ from Hungarian to Serbian, to make necessary cultural adaptations and to test its psychometric properties in a sample of outpatients with headache.MethodsThe CHQQ was translated and adapted according to internationally accepted guidelines, and then tested on a sample of 216 Serbian headache patients (171 females and 45 males, mean age 42.3 years/SD 13.35; range 18–75). The majority of patients suffered from episodic tension-type headache (TTH); 27 (12.5 %) had episodic migraine. We calculated the internal consistency (Cronbach’s alpha), criterion validity (correlations of individual items, dimensions and whole questionnaire with the clinical characteristics of headache), convergent validity (correlations of the abovementioned scores with results of other instruments measuring headache severity and impact), and discriminative validity (comparison of the scores in the two diagnostic groups) of the CHQQ. We used factor analysis to explore the underlying construct.ResultsThe Serbian translation of CHQQ showed excellent internal consistency, both for the whole instrument (Cronbach’s alpha 0.937) and its dimensions. The validity of the instrument in all aspects (criterion, convergent and discriminative validity) was also excellent when the whole sample and the subgroup of patients with TTH were analyzed, while the results for patients with migraine were less favorable. Factor analysis suggested the existence of a single dimension in this sample.ConclusionsThe Serbian translation of CHQQ is as reliable and valid specific instrument for measuring headache-related quality of life in patients with TTH and probably in patients with migraine.

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Circulating microparticles in migraine with aura: Cause or consequence, a link to stroke

Cited by 4 publications

References 31 publications

Migraine and Stroke: What’s the Link? What to Do?

Migraine and Stroke: What’s the Link? What to Do?

Migraine and the risk of stroke: a systematic review and meta-analysis

The psychometric properties of the Comprehensive Headache-related Quality of life Questionnaire (CHQQ) translated to Serbian

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