Circulating microRNA-301 as a promising diagnostic biomarker of hepatitis C virus-related hepatocellular carcinoma

El-Hamouly, Moamena S; Azzam, Ayman; Ghanem, Samar; Elbassal, Fathia; Shebl, Nashwa; Shehata, A.

doi:10.1007/s11033-019-05009-w

Cited by 12 publications

(6 citation statements)

References 24 publications

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“…After preliminary selection, 1858 articles were removed due to duplicate records and unfit literary forms. Finally, 16 articles were included according to inclusion and exclusion criteria [9][10][11][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Included Studiesmentioning

confidence: 99%

Diagnostic accuracy of circulating microRNAs for hepatitis C virus-associated hepatocellular carcinoma: a systematic review and meta-analysis

Huang

Chen

et al. 2022

BMC Infect Dis

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Aims The purpose of this study was to perform an assessment of circulating microRNAs (miRNAs) as promising biomarker for hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCV-HCC) through a meta-analysis. Methods A comprehensive literatures search extended up to March 1, 2020 in PubMed, Cochrane library, Embase, Web of Science, Scopus and Ovid databases. The collected data were analyzed by random-effects model, the pooled sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were used to explore the diagnostic performance of circulating miRNAs. Meta-regression and subgroup analysis were further carried out to explore the heterogeneity. Results A total of 16 articles including 3606 HCV-HCC patients and 3387 HCV patients without HCC were collected. The pooled estimates indicated miRNAs could distinguish HCC patients from chronic hepatitis C (CHC) and HCV-associated liver cirrhosis (HCV-LC), with a SEN of 0.83 (95% CI, 0.79–0.87), a SPE of 0.77 (95% CI, 0.71–0.82), a DOR of 17 (95% CI, 12–28), and an AUC of 0.87 (95% CI, 0.84–0.90). The combination of miRNAs and AFP showed a better diagnostic accuracy than each alone. Subgroup analysis demonstrated that diagnostic accuracy of miRNAs was better for plasma types, up-regulated miRNAs, and miRNA clusters. There was no evidence of publication bias in Deeks’ funnel plot. Conclusions Circulating miRNAs, especially for miRNA clusters, have a relatively high diagnostic value for HCV-HCC from CHC and HCV-LC.

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Section: Included Studiesmentioning

confidence: 99%

Diagnostic accuracy of circulating microRNAs for hepatitis C virus-associated hepatocellular carcinoma: a systematic review and meta-analysis

Huang

Chen

et al. 2022

BMC Infect Dis

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show abstract

“…After preliminary selection, 1858 articles were removed due to duplicate records and un t literary forms. Finally, 16 articles were included according to inclusion and exclusion criteria [9][10][11][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Included Studiesmentioning

confidence: 99%

Diagnostic Accuracy of Circulating microRNAs for Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Zhang

Tong

Huang

et al. 2021

Preprint

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Aims: The purpose of this study was to perform an assessment of circulating microRNAs as promising biomarker for Hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCV-HCC) through a meta-analysis.Methods: A comprehensive literatures search extended up to March 1, 2020 in PubMed, Cochrane library, Embase, Web of Science, Scopus and Ovid databases. The collected data were analyzed by random-effects model because of high heterogeneity, the pooled sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were used to explore the diagnostic performance of circulating miRNAs. Subgroup and threshold effect analysis were further carried out to explore the heterogeneity. Results: Overall, 16 articles that included a total of 3606 HCV-HCC patients and 3387 HCV patients without HCC were collected. The pooled estimates indicated miRNAs could distinguish HCC patients from chronic hepatitis C (CHC) and HCV-associated liver cirrhosis (HCV-LC), with a SEN of 0.83 (95% CI, 0.79-0.87), a SPE of 0.77 (95% CI, 0.71-0.82), a DOR of 17 (95% CI, 12-28), and an AUC of 0.87 (95% CI, 0.84-0.90). The combination of miRNAs and AFP showed a better diagnostic accuracy than each alone. Subgroup analysis demonstrated that diagnostic accuracy of miRNAs was better for plasma types, up-regulated miRNAs, and miRNA clusters. There was no evidence of publication bias in Deeks’ funnel plot.Conclusions: The summarized results suggested that circulating miRNAs, especially for miRNA clusters, have a relatively high diagnostic value for HCV-HCC, which could be served as non-invasive screening tool.

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“…In addition to this recent analysis, other studies evaluated different miRNA combinations in order to discriminate HCV patients with cirrhosis from those who are at risk of developing HCC [41][42][43][44][45]. MiR-301 seems to be a promising molecule with 78.57% sensitivity and 89.58% specificity in distinguishing HCV-HCC from HCV chronic hepatitis [46]. MiR-301 levels were significantly linked with tumor size and serum alpha-fetoprotein (AFP) [46].…”

Section: Micrornas In Hcv Related Hccmentioning

confidence: 99%

“…MiR-301 seems to be a promising molecule with 78.57% sensitivity and 89.58% specificity in distinguishing HCV-HCC from HCV chronic hepatitis [46]. MiR-301 levels were significantly linked with tumor size and serum alpha-fetoprotein (AFP) [46]. In a similar way, a combination of miR-224 with AFP shows sensitivity, specificity, and accuracy of 95.0%, 92.1%, and 93.2%, respectively in discriminating HCC from LC [47].…”

Section: Micrornas In Hcv Related Hccmentioning

confidence: 99%

The Relevance of MicroRNAs in the Pathogenesis and Prognosis of HCV-Disease: The Emergent Role of miR-17-92 in Cryoglobulinemic Vasculitis

Lorini

Gragnani

Zignego

2020

Viruses

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Hepatitis C virus (HCV) is a major public health problem. HCV is a hepatotropic and lymphotropic virus that leads to hepatocellular carcinoma (HCC) and lymphoproliferative disorders such as cryoglobulinemic vasculitis (CV) and non-Hodgkin’s lymphoma (NHL). The molecular mechanisms by which HCV induces these diseases are not fully understood. MicroRNAs (miRNAs) are small non-coding molecules that negatively regulate post-transcriptional gene expression by decreasing their target gene expression. We will attempt to summarize the current knowledge on the role of miRNAs in the HCV life cycle, HCV-related HCC, and lymphoproliferative disorders, focusing on both the functional effects of their deregulation as well as on their putative role as biomarkers, based on association analyses. We will also provide original new data regarding the miR 17-92 cluster in chronically infected HCV patients with and without lymphoproliferative disorders who underwent antiviral therapy. All of the cluster members were significantly upregulated in CV patients compared to patients without CV and significantly decreased in those who achieved vasculitis clinical remission after viral eradication. To conclude, miRNAs play an important role in HCV infection and related oncogenic processes, but their molecular pathways are not completely clear. In some cases, they may be potential therapeutic targets or non-invasive biomarkers of tumor progression.

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Circulating microRNA-301 as a promising diagnostic biomarker of hepatitis C virus-related hepatocellular carcinoma

Cited by 12 publications

References 24 publications

Diagnostic accuracy of circulating microRNAs for hepatitis C virus-associated hepatocellular carcinoma: a systematic review and meta-analysis

Diagnostic accuracy of circulating microRNAs for hepatitis C virus-associated hepatocellular carcinoma: a systematic review and meta-analysis

Diagnostic Accuracy of Circulating microRNAs for Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

The Relevance of MicroRNAs in the Pathogenesis and Prognosis of HCV-Disease: The Emergent Role of miR-17-92 in Cryoglobulinemic Vasculitis

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