Circulating microRNAs as Biomarkers of Alzheimer’s Disease: A Systematic Review

Abstract

Individual studies suggest that miRNAs can differentiate patients with AD/MCI from cognitively normal controls with modest accuracy. However, the literature is constrained by methodological differences between studies, with few studies assessing the same miRNAs. To become potential biomarkers for AD, further studies with standardized study designs for replication and validation are required. Results from this review may help researchers select candidate miRNAs for further investigation.

MicroRNA expression data analysis to identify key miRNAs associated with Alzheimer's disease

“…In the present study, a total of 13 key miRNAs were identified from nine selected miRNA profiling datasets, including four significantly up‐regulated miRNAs and nine significant down‐regulated miRNAs. Among the four up‐regulated miRNAs, hsa‐miR‐9 and hsa‐miR‐34a were up‐regulated in AD patients in accordance with a recent systematic review . The up‐regulated feature of hsa‐miR‐34a was observed in human studies and then confirmed by animal experiments on mice .…”

Delirium and Alzheimer disease: A proposed model for shared pathophysiology

“…Dysregulated miRs may influence gene transcription, protein expression and induce the spread of neurodegeneration 51 . The most consistently dysregulated miRNA markers for AD include miR-29b, miR-181c miR-15b, miR-146a, and miR-107 where uniform results have been observed in at least two independent studies 52 …”

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

“…Interestingly, this is one of the most frequently appearing miRNAs in AD studies, as it was found upregulated in AD patients in body fluids in three independent studies [25] and is dysregulated in post-mortem brains [26]. On the molecular level, the influence of miR-132-3p on the transcription factor, nuclear factor κB (NF-κB), i.e., induction of NF-κB translocation to the nucleus as a preamble for cytokine (IL-8 and MCP-1 production) [27], is of potential relevance for the association of increased miR-132-3p with decreased CCS in the present study.…”