Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications

Tsochandaridis, Marthe; Nasca, Laurent; Toga, C.; Levy‐Mozziconacci, Annie

doi:10.1155/2015/294954

Cited by 68 publications

(58 citation statements)

References 63 publications

(94 reference statements)

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“…The fact that four circulating miRNAs (miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p) were differentially expressed in the sera of women who later developed PE compared with women who did not develop PE, confirms the possible pathophysiological role of miRNAs in PE, as previously suggested (19,52,53). Particularly, exploring the role of miR-1233 and miR-574 in PE could enrich our understanding of this disease.…”

Section: Discussionsupporting

confidence: 78%

“…They are critical in many biological processes, including the regulation of cell differentiation, proliferation, apoptosis, angiogenesis, and metabolism (17). Specific plasma-related miRNAs were identified in maternal plasma or serum in normal pregnancies, as well as in pathological pregnancy conditions, such as PE (18,19). Several recent reports described the significant dysregulation of specific miRNA expression in the maternal circulation of PE patients compared with controls (miR-24, miR-26a, miR-29a, miR-103, miR-130b, miR-141, miR-144, miR-152, miR-181a, miR-210, miR-342-3p, miR-520, miR-574-5p, and miR-1233) (20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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Dysregulated circulating miRNAs in preeclampsia

et al. 2016

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Abstract. Preeclampsia (PE) is a pregnancy-related disease with potentially severe consequences with respect to foeto-maternal morbidity and mortality. However, the molecular pathogenesis of PE remains largely unknown. Recent reports have shown that microRNAs (miRNAs or miRs) may play important roles in the development of PE. Analysing the miRNAs in sera from preeclamptic women may improve our understanding of the pathophysiological mechanisms of the disease. The aim of this retrospective study was to identify whether circulating miRNAs were differentially expressed in PE patients compared with controls. Serum samples from 23 women who developed PE were compared with samples from 44 pregnant controls. Seventeen circulating miRNAs previously described in PE were chosen for evaluation of their expression by reverse transcription quantitative polymerase chain reaction (RT-qPCR). In the maternal serum, the miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p levels were found to be significantly higher in the PE patients than in the controls (P<0.05). Using a logistic regression model, we evaluated the discriminant power of those differentially expressed miRNAs, and the combination of miR-210-5p and miR-574-5p yielded an area under the curve of 0.7223 for discriminating PE patients from the controls. In conclusion, the fact that four circulating miRNAs (miR-210-3p, miR-210-5p, miR-1233-3p, and miR-574-5p) were differentially expressed in the sera of women who developed PE compared with controls confirms the possible pathophysiological role of miRNAs in PE.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Dysregulated circulating miRNAs in preeclampsia

et al. 2016

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“…Around 90% of the EVs in plasma are platelet-derived while those from the placenta represent less than 3% even in PE . MicroRNAs as biomarkers were the subject of an excellent recent review, which highlights progress in using particular circulating microRNAs that show altered expression in PE (Tsochandaridis et al 2015).…”

Section: Micrornasmentioning

confidence: 99%

Placenta-derived extracellular vesicles: their cargo and possible functions

Familari

Cronqvist

Masoumi

et al. 2017

Reprod. Fertil. Dev.

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The literature on extracellular vesicles consists of rapidly expanding and often contradictory information. In this paper we attempt to review what is currently known regarding extracellular vesicles released specifically from human placental syncytiotrophoblast cells with a focus on the common but complex pregnancy-associated syndrome pre-eclampsia, where the level of syncytiotrophoblast extracellular vesicle release is significantly increased. We review common methods for syncytiotrophoblast extracellular vesicle derivation and isolation and we discuss the cargo of syncytiotrophoblast extracellular vesicles including proteins, RNA and lipids and their possible functions. A meta-analysis of available trophoblast-derived extracellular vesicle proteomic datasets revealed only three proteins in common: albumin, fibronectin-1 and plasminogen activator inhibitor-1, suggesting some variability in vesicle cargo, most likely reflecting stage and cell type of origin. We discuss the possible sources of variability that may have led to the low number of common markers, which has led us to speculate that markers and density in common use may not be strict criteria for identifying and isolating placenta-derived exosomes.

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“…31 Hence, whereas prospective biomarkers may be identified by comparing normal with pathological placentae, direct comparison of plasma profiles of women with normal and complicated pregnancies can offer novel candidates. 32,33 In addition to maternal blood plasma, blood serum and urine may yield adequate concentration and integrity of target fragments.…”

Section: Analysis Approachesmentioning

confidence: 99%

Noninvasive nucleic acid–based approaches to monitor placental health and predict pregnancy-related complications

Manokhina

Wilson

Robinson

2015

American Journal of Obstetrics and Gynecology

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During pregnancy, the placenta releases a variety of nucleic acids (including deoxyribonucleic acid, messenger ribonucleic acid, or microribonucleic acids) either as a result of cell turnover or as an active messaging system between the placenta and cells in the maternal body. The profile of released nucleic acids changes with the gestational age and has been associated with maternal and fetal parameters. It also can directly reflect pathological changes in the placenta. Nucleic acids may therefore provide a rich source of novel biomarkers for the prediction of pregnancy complications. However, their utility in the clinical setting depends, first, on overcoming some technical considerations in their quantification, and, second, on developing a better understanding of the factors that influence their function and abundance.

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Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications

Cited by 68 publications

References 63 publications

Dysregulated circulating miRNAs in preeclampsia

Dysregulated circulating miRNAs in preeclampsia

Placenta-derived extracellular vesicles: their cargo and possible functions

Noninvasive nucleic acid–based approaches to monitor placental health and predict pregnancy-related complications

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