Circulating microRNAs: novel biomarkers for early detection of colorectal cancer

Aravalli, Rajagopal N.; Steer, Clifford J.

doi:10.1016/j.trsl.2015.04.007

Cited by 7 publications

(6 citation statements)

References 64 publications

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“…MiR-143 regulates proliferation and apoptosis in cancers, including intestinal cancer, breast cancer, and gastric cancer [ 11 , 28 , 29 ]. Previously, we determined that cfa-miR-143 is upregulated in CIV H3N2-infected dog lungs in a deep sequencing study [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Since 2002, researchers have explored the roles and relevant mechanisms of miRNAs in many diseases, such as cancer [ 3 , 4 , 5 , 6 , 7 ] and viral infections [ 8 , 9 , 10 ]. Moreover, miRNAs are considered potential biomarkers in some cancers based on miRNA expression analysis in cancerous tissues [ 11 ]. For example, high expression of miR-143 serves as a prognostic marker of gastric cancer [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…We have previously shown that cfa-miR-143 is upregulated in the lungs of CIV H3N2-infected dogs [ 27 ]. miR-143 regulates proliferation and apoptosis in cancers, including intestinal cancer, breast cancer, and gastric cancer [ 11 , 28 , 29 ]. It has been speculated that cfa-miR-143 directly binds to the 3′-untranslated region (UTR) of the insulin-like growth factor binding protein 5 gene (Igfbp5).…”

Section: Introductionmentioning

confidence: 99%

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cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells

Zhou

Lin

et al. 2017

Viruses

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MicroRNAs regulate multiple aspects of the host response to viral infection. This study verified that the expression of cfa-miR-143 was upregulated in vivo and in vitro by canine influenza virus (CIV) H3N2 infection. To understand the role of cfa-miR-143 in CIV-infected cells, the target gene of cfa-miR-143 was identified and assessed for correlations with proteins involved in the apoptosis pathway. A dual luciferase reporter assay showed that cfa-miR-143 targets insulin-like growth factor binding protein 5 (Igfbp5). Furthermore, a miRNA agomir and antagomir of cfa-miR-143 caused the downregulation and upregulation of Igfbp5, respectively, in CIV-infected madin-darby canine kidney (MDCK) cells. This study demonstrated that cfa-miR-143 stimulated p53 and caspase3 activation and induced apoptosis via the p53 pathway in CIV H3N2-infected cells. In conclusion, CIV H3N2 induced the upregulation of cfa-miR-143, which contributes to apoptosis via indirectly activating the p53-caspase3 pathway.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells

Zhou

Lin

et al. 2017

Viruses

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“…miRNAs demonstrate the same change in expression in plasma, serum, feces, and tumor tissues of patients with various types of cancer 38,39. Studies in human cancer cell lines showed that miR-203 could target tumor suppressor genes, such as CDK6 ,40 AKT2 ,41 Survivin ,42 and ZNF217 43.…”

Section: Discussionmentioning

confidence: 99%

miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis

Hao

Wang

et al. 2017

OTT

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We sought to systematically evaluate the diagnostic and prognostic value of miR-203 in patients with colorectal cancer. To explore the diagnostic performance of miR-203, eligible studies were identified from biomedical databases. Based on these results, 11 studies were pooled and included in this meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratios of miR-203 were 0.83 (95% confidence interval, CI: 0.78–0.86), 0.80 (95% CI: 0.77–0.83), and 19.27 (95% CI: 7.23–51.36) for the diagnosis of colorectal cancer. The area under the curve for miR-203 for diagnosing colorectal cancer was 0.89. Patients with higher expression of tissue miR-203 had poor overall survival (pooled hazard ratio: 1.63; 95% CI: 1.03–2.57, P=0.04), but serum miR-203 was not predictive (pooled hazard ratio: 1.59; 95% CI: 0.31–8.12, P=0.58). The miR-203 values of tissue and serum merged together may perhaps predict superior overall survival (pooled hazard ratio: 1.62; 95% CI: 0.93–2.82), but the effect was not significant (P=0.09).

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“…miRNAs demonstrate the same change in expression in plasma, serum, feces, and tumor tissues of patients with various types of cancer [32, 33]. Studies in human cell lines further investigated the physiologic targets of miR106a, and showed that miR106a could target tumor-suppressor genes, such as RUNX3, Twist1, pRB and E2F1 [34].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of miR-106a in colorectal cancer

et al. 2016

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We sought to systematically evaluate the diagnostic and prognostic value miR106a in patients with colorectal cancer (CRC). An original study was conducted to explore correlations between tissue miR106a levels and outcomes for 138 patients diagnosed with CRC. To explore the diagnostic performance of miR106a, eligible studies were identified from medical databases from China and abroad. Based on these results, 15 studies (including our original study) were pooled and included in a meta-analyses. The pooled sensitivity, specificity, and diagnostic odds ratios of miR106a were 0.53 (95% confidence interval (CI): 0.49–0.57), 0.85 (95% CI: 0.82–0.88), and 7.22 (95% CI: 3.17–16.44) for diagnosis of CRC, and the area under the curve (AUC) for miR106a when diagnosing CRC was 0.72. Patients with higher expression of tissue miR106a had poor overall survival (pooled hazard ratio (HR): 1.50; 95% CI: 1.02–2.20), but not disease-free survival (pooled HR: 1.03; 95% CI: 0.40–2.65). Overexpression of miR106a may predict superior metastasis-free survival (pooled HR: 0.65; 95% CI: 0.33–1.27), but the effect was not significant in this study (p = 0.21).

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Circulating microRNAs: novel biomarkers for early detection of colorectal cancer

Cited by 7 publications

References 64 publications

cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells

cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells

miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis

Diagnostic and prognostic value of miR-106a in colorectal cancer

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