Circulating miR-21 as novel biomarker in gastric cancer

Simonian, Miganoosh; Mosallayi, Meysam; Mirzaei, Hamed

doi:10.4103/0973-1482.175428

Cited by 96 publications

(23 citation statements)

References 5 publications

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“…[52][53][54][55][56][57][58] It has been showed that deregulation of this molecules are associated with initiation and progression of various diseases and pathological conditions. [59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] Increasing evidence showed that curcumin and various drugs can exert their effects by up-and downregulation of many miRNAs. 4,6 Sreenivasan et al, 43 assessed the effects of curcumin as a therapeutic agent on Y79 RB cells through upregulation of miR-22, which is known as a tumor suppressor miRNA.…”

Section: Introductionmentioning

confidence: 99%

“…These molecules via affecting a wide range of cellular and molecular targets exert their regulatory effects . It has been showed that deregulation of this molecules are associated with initiation and progression of various diseases and pathological conditions . Increasing evidence showed that curcumin and various drugs can exert their effects by up‐ and downregulation of many miRNAs .…”

Section: Introductionmentioning

confidence: 99%

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Curcumin: A new candidate for retinal disease therapy?

Farajipour

Rahimian

Taghizadeh

2018

J of Cellular Biochemistry

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The retina is the neural portion and light‐sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light‐sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. It has been shown that many pathogenesis conditions, including inﬂammation, angiogenesis, oxidative stress, and imbalanced histone modiﬁcations in the retina are associated with initiation and progression of retinal diseases (ie, glaucoma, diabetic retinopathy, and age‐related macular degeneration). Currently available treatments include laser surgery, freezing, stem‐cell therapy, shrinking abnormal blood vessels. It has some limitations, such as invasive methods, high costs, and many side effects. Hence, finding a new therapeutic platform for stopping or slowing of the disease progression is required. Curcumin is a natural product, which is associated with a wide range of properties, such as antioxidant, anti‐inflammatory, antiangiogenic, and antitumor activates. It exerts therapeutic effects via activation/inhibition cellular and molecular targets involved in various diseases, such as retinal diseases. Increasing evidence revealed that curcumin can be used as a therapeutic option in the treatment of different retinal diseases. Here, we summarized various clinical and preclinical studies that used curcumin as a therapeutic agent in the treatment of retinal disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin: A new candidate for retinal disease therapy?

Farajipour

Rahimian

Taghizadeh

2018

J of Cellular Biochemistry

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“…22,61,[63][64][65][66][67][68][69][70][71][72] Therefore, miRNAs and their targeting may be used as therapeutic, diagnostic, and prognostic markers in treatment of different diseases. 36,44,56,[73][74][75][76][77][78][79][80][81][82] These findings indicate that more exosomes enforce their oncogenic impacts through influencing miRNAs. For instance, Yeh et al reported that exosomes derived from plasma of CLL subjects were endowed with a leukemia-related miRNA profile including miR-223, miR-29 family, miR-150, miR-155, and miR-223 that could be linked to inadequate disease outcomes in CLL.…”

Section: Introductionmentioning

confidence: 84%

Leukemia‐derived exosomes: Bringing oncogenic signals to blood cells

Mirzaei

Shafiee

Molavi

et al. 2019

J of Cellular Biochemistry

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Leukemia is a cancer, which is derived from leukocytes and precursors of leukocytes in the bone marrow. A large number of pivotal biological processes are linked to leukemia pathogenesis. More insights into these mechanisms can provide a better developing pharmacological platform for patients with leukemia. Among the different players in leukemia pathogenesis, exosomes have appeared as a new biological vehicle, which can transfer oncogenic signals to blood cells. Exosomes are nano‐carriers, which enable transferring numerous cargos such as DNA fragments, RNAs, messenger RNAs, microRNAs, long noncoding RNA, and proteins. Targeting the contents of exosomes leads to the alteration of host cell behavior. Increasing evidence has indicated that leukemia‐derived exosomes could be utilized as prognostic, diagnostic, and therapeutic biomarkers for individuals suffering from leukemia. In this regard, the importance of exosomes in terms of initiation and progression of leukemia was underlined in this study.

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“…Therefore there is a need to identify novel biomarkers that can be used for the early detection, diagnosis, and therapeutic targets. Based on previous studies, miRNAs have been shown to influence gastric cancer tumorigenesis 38–40 . Among them, miR‐34a 41 antagonizes the development of gastric cancer.…”

Section: Role Of Mir‐34a In the Regulation Of Anti‐tumor Immunity And...mentioning

confidence: 99%

Anti‐tumor effects of miR‐34a by regulating immune cells in the tumor microenvironment

2023

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Malignant tumors pose a serious threat to human health. The development of malignant tumors is characterized by uncontrolled cell division and immune evasion. The micro‐ribonucleic acid‐34a (miR‐34a) is a small noncoding single‐stranded ribonucleic acid that is ubiquitously present in normal human tissues. However, it has been confirmed to be dysregulated in a variety of tumor cells. Numerous research have revealed the importance of miR‐34a in the treatment of various malignancies. MiR‐34a deletion can hasten the growth of tumors whereas miR‐34a overexpression suppresses the proliferation, invasion, and migration of cancer cells. Moreover, more recent studies have highlighted its role in immunity and investigated its applicability to particular tumors. Through various immune cells, factors, and other mechanisms, miR‐34a can inhibit tumor carcinogenesis. In view of the important role of miR‐34a in tumors, this research reviewed the aspects of miR‐34a regulation of tumor immune microenvironment to exert anti‐tumor effects in order to clarify the potential immunotherapy value of miR‐34a in tumors.

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Circulating miR-21 as novel biomarker in gastric cancer

Cited by 96 publications

References 5 publications

Curcumin: A new candidate for retinal disease therapy?

Curcumin: A new candidate for retinal disease therapy?

Leukemia‐derived exosomes: Bringing oncogenic signals to blood cells

Anti‐tumor effects of miR‐34a by regulating immune cells in the tumor microenvironment

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