Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly

Chen, Pengcheng; Deng, Wenhai; Li, Dandan; Zeng, Tai; Huang, Ling; Wang, Qun; Wang, Jinli; Zhang, Weiguang; Yu, Xiaoxiao; Duan, Deming; Wang, Jinle; Xia, Hong; Chen, Hanbin; Huang, Wesley; Li, Jingao; Zhang, Dahong; Zhong, Xiao‐Ping; Gao, Jimin

doi:10.3389/fimmu.2019.00260

Cited by 54 publications

(66 citation statements)

References 40 publications

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“…Of note, one person with diabetes had a significant proportion of CD4 + MAIT cells (47.2%). Such a high frequency of circulating CD4 + MAIT cells is not uncommon and has been reported before in healthy individuals (32). No significant differences in iNKT or Vδ2 + T cell subsets were observed (Figures 1C,D).…”

Section: Metabolic Disease-associated Differences In Ex Vivo Activatisupporting

confidence: 83%

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease

Woods

Parry‐Strong

et al. 2020

Front. Immunol.

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The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing cells, have been reported to promote metabolic homeostasis. However, these different ILT cell subsets have, to date, been generally studied in isolation. Here we conducted a pilot study assessing the phenotype and function of circulating MAIT, iNKT, and Vδ2 + T cells in a small cohort of 10 people with obesity and type 2 diabetes (T2D), 10 people with obesity but no diabetes, and 12 healthy individuals. We conducted phenotypic analysis by flow cytometry ex vivo, and then functional analysis after in vitro stimulation using either PMA/ionomycin or synthetic agonists, or precursors thereof, for each of the cell-types; use of the latter may provide important knowledge for the development of novel therapeutics aimed at activating human ILT cells. The results of our pilot study, conducted on circulating cells, show clear dysfunction of all three ILT cell subsets in obese and obese T2D patients, as compared to healthy controls. Importantly, while both iNKT and Vδ2 + T cell dysfunctions were characterized by diminished IL-2 and interferon-γ production, the distinct dysfunctional state of MAIT cells was instead defined by skewed subset composition, heightened sensitivity to T cell receptor engagement and unchanged production of all measured cytokines.

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Section: Metabolic Disease-associated Differences In Ex Vivo Activatisupporting

confidence: 83%

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease

Woods

Parry‐Strong

et al. 2020

Front. Immunol.

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“…However, the reason for this change is less clear. Some studies found the peripheral MAIT cells were age-related and changed with age [48][49][50]. The most common explanation for the reduction was attributed to the apoptosis [17,51].…”

Section: Ivyspringmentioning

confidence: 99%

Mucosal-Associated Invariant T cell in liver diseases

Zhang¹,

Kong²,

Wang³

2020

Int. J. Biol. Sci.

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Mucosal-associated invariant T cells (MAIT cells) are a new population of innate immune cells, which are abundant in the liver and play complex roles in various liver diseases. In this review, we summarize MAIT cells in the liver diseases in recent studies, figure out the role of MAIT cells in various liver disease, including Alcoholic liver disease, Non-alcoholic liver disease, Autoimmune liver diseases, Viral hepatitis and Liver Cancer. Briefly, MAIT cells are involved in anti-bacteria responses in the alcoholic liver diseases. Besides, the activated MAIT cells promote the liver inflammation by secreting inflammatory cytokines and produce regulatory cytokines, which induces anti-inflammatory macrophage polarization. MAIT cells participate in the liver fibrosis via enhancing hepatic stellate cell activation. In viral hepatitis, MAIT cells exhibit a flawed and exhausted phenotype, which results in little effect on controlling the virus and bacteria. In liver cancer, MAIT cells indicate the disease progression and the outcome of therapy. In summary, MAIT cells are attractive biomarkers and therapeutic targets for liver disease.

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“…The copyright holder for this preprint this version posted December 1, 2020. ; https://doi.org/10.1101/2020.12.01.407148 doi: bioRxiv preprint setting. This difference can be explained by the rate of physiological aging-related attrition of MAIT cells that is substantially less pronounced in female blood (40)(41)(42). The resultant higher frequencies in circulation enabled us to readily uncover the precipitous percentage drop we saw with MAIT cells relative to exposed/infected females.…”

Section: Discussionmentioning

confidence: 94%

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19

Littleton

Giroux

et al. 2020

Preprint

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Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral blood mononuclear cells from confirmed COVID-19 inpatients and outpatients, uninfected close contacts, and healthy controls for 36-color flow cytometry and single cell RNA-sequencing. Our results revealed a pronounced reduction of circulating mucosal associated invariant T (MAIT) cells in infected females. Integration of published COVID-19 airway tissue datasets implicate that this reduction represented a major wave of MAIT cell extravasation during early infection in females. Moreover, female MAIT cells possessed an immunologically active gene signature, whereas male counterparts were pro-apoptotic. Collectively, our findings uncover a female-specific protective MAIT profile, potentially shedding light on reduced COVID-19 susceptibility in females.

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Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly

Cited by 54 publications

References 40 publications

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease

Mucosal-Associated Invariant T cell in liver diseases

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19

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